Results 11 to 20 of about 4,746 (159)
Crystal structure of a murine α-class glutathione S-transferase involved in cellular defense against oxidative stress [PDF]
, 1998 Glutathione S-transferases (GSTs) are ubiquitous multifunctional enzymes which play a key role in cellular detoxification. The enzymes protect the cells against toxicants by conjugating them to glutathione.
Arkema, Anita, +6 more
core +2 more sources
Understanding and targeting resistance mechanisms in cancer
MedComm, Volume 4, Issue 3, June 2023., 2023 The reduced responsiveness of cancer cells can be associated with various mechanisms, including drug inactivation, reduced intracellular drug accumulation by reduced uptake or increased efflux, drug target alteration, activation of compensatory pathways for cell survival, regulation of DNA repair and cell death, tumor plasticity, and the regulation ...
Zi‐Ning Lei +6 more
wiley +1 more source
Hypotensive Effect of Ethacrynic Acid [PDF]
Circulation, 1965 Ethacrynic acid has been found to possess a similar antihypertensive action to the thiazide diuretics. The use of the two drugs together results in a greater fall in pressure than that obtained with either drug alone. When thiazide therapy is supplemented by ethacrynic acid and dietary restriction of sodium a substantial additional reduction in blood ...
Gastone Leonetti, James Conway
openaire +3 more sources
Multiple pumps for sodium reabsorption by the perfused kidney [PDF]
, 1976 Multiple pumps for sodium reabsorption by the perfused kidney. Several distinct transport mechanisms responsible for sodium reabsorption by the rat kidney can be identified by studying the function of isolated perfused kidneys.
Besarab, Anatole +2 more
core +1 more source
Differential activities of glutathione s-transferase isoenzymes in strains of fasciola hepatica susceptible and resistant to triclabendazole [PDF]
, 2014 Fasciolosis, a parasitic zoonosis of intrahepatic location, is caused by the trematode Fasciola hepatica. Its control is mainly based on the use of the anthelminthic Triclabendazole (TCBZ).
Fernandez, Vanesa +3 more
core +1 more source
Bromocriptine-associated ototoxicity [PDF]
, 2007 Three patients treated with bromocriptine for chronic hepatic encephalopathy showed audiometric evidence of bilateral sensori-neural hearing-loss. Audiometrically, the hearing improved in all three patients when the bromocriptine dosage was reduced, thus
Ballantyne, J, Lanthier, PL, Morgan, MY
core +1 more source
Mechanism of osmotic diuresis [PDF]
, 1981 Mechanism of osmotic diuresis. Mannitol might inhibit para-cellular reabsorption of water and sodium chloride in the proximal tubules by reducing the osmotic driving force. We examined this hypothesis in anesthetized dogs.
Kiil, Fredrik +2 more
core +1 more source
Hypernatremia inhibits NaHCO3 reabsorption and associated NaCl reabsorption in dogs [PDF]
, 1986 Hypernatremia inhibits NaHCO3 reabsorption and associated NaCl reabsorption in dogs. To examine the effect of selective rise of plasma NaCl concentration (hypematremia) on NaHCO3 reabsorption and associated NaCl reabsorption remaining during continuous ...
Hartmann, Anders +4 more
core +1 more source
Ethacrynic Acid Induced Inotropism
Experimental Biology and Medicine, 1975 Ethacrynic acid (ECA), a sulfhydryl group inhibiting diuretic was examined for positive inotropic effects. These were found to be present in isolated guinea pig left atria studied in 0.9 and 1.8 mM Ca bathing solutions and were partially dependent upon adrenergic mechanisms (presumably secondary to norepinephrine release from sympathetic nerve endings)
Arthur H. L. From +2 more
openaire +3 more sources
Nano-hole induction by nanodiamond and nanoplatinum liquid, DPV576, reverses multidrug resistance in human myeloid leukemia (HL60/AR). [PDF]
, 2013 Recently nanoparticles have been extensively studied and have proven to be a promising candidate for cancer treatment and diagnosis. In the current study, we examined the chemo-sensitizing activity of a mixture of nanodiamond (ND) and nanoplatinum (NP ...
Ghoneum, Alia +2 more
core +2 more sources