Results 21 to 30 of about 4,746 (159)

Cellular Iron Depletion Weakens Induction of Heme Oxygenase-1 by Cadmium [PDF]

, 2011
Heme oxygenase-1 is an inducible cytoprotective gene, although its induction by environmental factors is not completely understood. This study aimed to ascertain if specific nutritive factors or related compounds influence heme oxygenase-1 expression. In
Lai, Chengzhi, Loo, George, NC DOCKS at The University of North Carolina at Greensboro   +2 more
core   +1 more source

Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials [PDF]

, 2006
Recent studies suggest that the toxicity of familial amyotrophic lateral sclerosis mutant Cu, Zn superoxide dismutase (SOD1) arises from its selective recruitment to mitochondria. Here we demonstrate that each of 12 different familial ALS-mutant SOD1s
Butler Gralla, Edith, Carrì, Maria Teresa, Casciati, Arianna, Cozzolino, Mauro, Crosio, Claudia, Ferri, Alberto, Nencini, Monica, Rotilio, Giuseppe, Valentine, Joan Selverstone   +8 more
core   +2 more sources

Anticancer ruthenium(II) tris(pyrazolyl)methane complexes with bioactive co-ligands [PDF]

, 2022
In comparison with Ru-II-arene compounds, the medicinal potential of homologous Ru-II-tpm compounds [tpm = tris(pyrazolyl)methane] is underexplored. Pyridine, 4-pyridinemethanol and four functionalized pyridines, synthesized from the esterification of 4 ...
Biancalana, Lorenzo, Dyson, Paul J, Gobbo, Alberto, Marchetti, Fabio, Pereira, Sarah A P, Saraiva, M Lúcia M F S, Zacchini, Stefano   +6 more
core   +1 more source

Unraveling the functional dynamics of Caenorhabditis elegans stress‐responsive omega class GST‐44

The FEBS Journal, EarlyView.
Omega‐class glutathione S‐transferases (GSTs) are integral to redox regulation and cellular stress responses. This study characterized GST‐44 in Caenorhabditis elegans, revealing its predominant expression in the intestine and excretory H‐cell, with significant upregulation under various stress conditions.
Charlotte Sophia Kaiser, Milena Lubisch, Emma Schröder, Luka Ressmann, Marie Nicolaus, Dustin Leusder, Sven Moyzio, Robert Peuss, Antonio Miranda‐Vizuete, Eva Liebau   +9 more
wiley   +1 more source

Modulation of doxorubicin cytotoxicity by ethacrynic acid [PDF]

International Journal of Cancer, 1996
Energy-dependent membrane efflux pumps have been implicated in mediating resistance to doxorubicin (DOX). Membrane-transport mechanisms distinct from P-glycoprotein, capable of transporting DOX and glutathione conjugates have been reported in human cells. Since glutathione-conjugate-forming compounds may be candidates for modulating the cytotoxicity of
Yogesh C. Awasthi, Sanjay K. Srivastava, Shivendra V. Singh, Meena Chaubey, Piotr Zimniak, Sharad S. Singhal, Sanjay Awasthi, Nong-Gao He   +7 more
openaire   +3 more sources

Recent advances in the structure, function and regulation of the volume‐regulated anion channels and their role in immunity

The Journal of Physiology, EarlyView.
Abstract figure legend The volume‐regulated anion channel (VRAC), composed of leucine‐rich repeat‐containing 8 (LRRC8) proteins, serves both canonical and non‐canonical functions in vertebrate cells. The canonical function of this channel relates to its original description, which is homeostatic regulation of cell volume in response to hypotonic ...
Sergei Yanushkevich, Aleksandra Zieminska, Joshua Gonzalez, Francisca Añazco, Richard Song, Alejandra Arias‐Cavieres, Sara T. Granados, Junyi Zou, Yan Rao, Axel R. Concepcion   +9 more
wiley   +1 more source

Ethacrynic Acid Ototoxicity Potentiation by Kanamycin [PDF]

Annals of Otology, Rhinology & Laryngology, 1973
The ototoxicity of ethacrynic acid and kanamycin in combination has been investigated during acute and chronic conditions of exposure. The effect of the combination of 10 mg/kg of ethacrynic acid and 100 mg/kg of kanamycin during both exposure conditions is manifested by a significantly greater drop in measured potentials than is present in the ...
Jiri Prazma, Newton D. Fischer, J. P. Browder   +2 more
openaire   +4 more sources

Inhibition of human glutathione transferases by pesticides: Development of a simple analytical assay for the quantification of pesticides in water [PDF]

, 2012
Glutathione transferases (GSTs; EC 2.5.1.18) form a group of multifunctional enzymes that are involved in phase II cellular detoxification mechanism.
Chronopoulou, Evangelia G., Labrou, Nikolaos E., Markoglou, Anastassios, Papageorgiou, Anastassios C.   +3 more
core   +1 more source

Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis

Neuropathology, Volume 45, Issue 3, Page 177-201, June 2025.
Oxidative stress in sporadic amyotrophic lateral sclerosis (ALS) has been evidenced by accumulation of oxidatively modified products of nucleic acids, lipids, sugars, and proteins in the motor neuron system of brains and spinal cords obtained at autopsy from the patients.
Noriyuki Shibata, Ikuko Kataoka, Yukinori Okamura, Kumiko Murakami, Yoichiro Kato, Tomoko Yamamoto, Kenta Masui   +6 more
wiley   +1 more source

New trends for metal complexes with anticancer activity [PDF]

, 2008
Medicinal inorganic chemistry can exploit the unique properties of metal ions for the design of new drugs. This has, for instance, led to the clinical application of chemotherapeutic agents for cancer treatment, such as cisplatin. The use of cisplatin is,
Ang, Ang, Barnard, Barnes, Bednarski, Bergamo, Bregman, Calderone, Casini, Debreczeni, Dixon, Dyson, Failes, Feazell, Guo, Habtemariam, Hall, Hambley, Hannon, Harris, Heringova, Hillard, Hotze, James, Jung, Komeda, Liu, Lutterman, MacDiarmid, Mackay, Mackay, McNae, Meggers, Milacic, Noor, Oleksi, Orvig, Ott, Pascu, Peacock, Peter J Sadler, Pieter CA Bruijnincx, Reed, Schatzschneider, Schlawe, Scolaro, Smalley, Sun, Thompson, Timerbaev, Urig, Urig, van Zutphen, Wang, Weidt, Yan, Yang   +56 more
core   +1 more source