Results 21 to 30 of about 6,190 (242)
Marmoset glutathione transferases with ketosteroid isomerase activity
Biochemistry and Biophysics Reports, 2021 The common marmoset Callithrix jacchus encodes two glutathione transferase (GST) enzymes with ketosteroid double-bond isomerase activity. The most active enzyme is CjaGST A3-3 showing a specific activity with 5-androsten-3,17-dione (Δ5-AD) of 62.1 ± 1.8 ...
Aram Ismail +2 more
doaj +1 more source
Antioxidants, 2020 Glutathione S-transferases (GSTs) are essential sperm antioxidant enzymes involved in cell protection against oxidative stress and toxic chemicals, preserving sperm function and fertilising ability.
Marc Llavanera +8 more
doaj +1 more source
Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer [PDF]
, 2016 Epidermal growth factor receptor (EGFR) inhibitors such as erlotinib are novel effective agents in the treatment of EGFR-driven lung cancer, but their clinical impact is often impaired by acquired drug resistance through the secondary T790M EGFR mutation.
Chater, E +13 more
core +2 more sources
The Mode of Action of Cyclo(l-Ala-l-Pro) in Inhibiting Aflatoxin Production of Aspergillus flavus
Toxins, 2017 Cyclo(l-Ala-l-Pro) inhibits aflatoxin production in aflatoxigenic fungi without affecting fungal growth. The mode of action of cyclo(l-Ala-l-Pro) in inhibiting aflatoxin production of Aspergillus flavus was investigated. A glutathione S-transferase (GST)
Kurin Iimura +5 more
doaj +1 more source
Bromocriptine-associated ototoxicity [PDF]
, 2007 Three patients treated with bromocriptine for chronic hepatic encephalopathy showed audiometric evidence of bilateral sensori-neural hearing-loss. Audiometrically, the hearing improved in all three patients when the bromocriptine dosage was reduced, thus
Ballantyne, J, Lanthier, PL, Morgan, MY
core +1 more source
Acute effect of prednisolone on renal handling of sodium. [PDF]
, 1973 The effect of prednisolone on renal handling of sodium (Na) was studied in rats under three experimental conditions: 1) hydropenia, 2) water diuresis, and 3) distal tubular blockade (DTB).
Halgrimson, CG +3 more
core +1 more source
Ototoxic effects and mechanisms of loop diuretics
Journal of Otology, 2016 Over the past two decades considerable progress has been made in understanding the ototoxic effects and mechanisms underlying loop diuretics. As typical representative of loop diuretics ethacrynic acid or furosemide only induces temporary hearing loss ...
Dalian Ding +8 more
doaj +1 more source
Inhibitors of bacterial and plants urease [PDF]
, 2013 Urease is an important virulence factor for Helicobacter pylori and Proteus mirabilis as well as in environmental transformations of certain nitrogenous compounds.
Macegoniuk, Katarzyna
core +1 more source
Insertion of (Bioactive) Equatorial Ligands into Platinum(IV) Complexes
Angewandte Chemie International Edition, Volume 62, Issue 46, November 13, 2023., 2023 We investigated the incorporation of equatorial ligands into platinum(IV) complexes, enabling the synthesis of otherwise unavailable complexes. Attachment of albumin‐targeting maleimide moieties led to increased tumor accumulation and anticancer activity compared to oxaliplatin. The presented strategy will allow the development of new types of targeted
Alexander Kastner +5 more
wiley +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 The linking of ethacrynic acid with ethylenediamine and 1,4-butanediamine gave EDEA and BDEA, respectively, as membrane-permeable divalent pro-inhibitors of glutathione S-transferase (GST).
Bangtian Xu +8 more
doaj +1 more source