Results 31 to 40 of about 4,746 (159)

Fish Fin‐Derived Non‐Invasive Flexible Bioinspired Contact Lens for Continuous Ophthalmic Drug Delivery

Advanced Science, Volume 12, Issue 6, February 10, 2025.
Inspired by the structure and reciprocating motion of fish dorsal fins, a drug‐eluting contact lens based on deformable microstructures for non‐invasive drug delivery is developed. The drug release rate can be adaptively adjusted to intraocular pressure changes and proactively regulated by cyclic ocular loads, enabling it to respond to elevated ...
Xu Li, Hui Li, Zihao Wang, Xianda Wang, Jinlong Zhang, Fengjiao Bin, Wei Chen, Hongyang Li, Dongmei Huo, Dengbao Xiao   +9 more
wiley   +1 more source

The Pharmacology of Newer Diuretics [PDF]

, 1967
There are now a number of different classes of diuretics with different pharmacologic effects. Several considerations dictate the choice of diuretic: 1. The responsiveness of the patient is of prime importance. If the patient is not known to be resistant
Wasserman, Albert J.
core   +1 more source

Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia [PDF]

, 2016
[Background] Mutations in the progranulin gene (GRN) are the most common cause of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). TDP-43 pathology is characterized by the hyperphosphorylation of the protein at Serine
Alquézar, Carolina, De la Encarnación, Ana, Gil, Carmen, López de Munain, Adolfo, Martín-Requero, Ángeles, Martínez, Ana, Moreno, Fermín, Pérez, Daniel I., Salado, Irene G.   +8 more
core   +1 more source

Observational study for multiparametric assessment of cardiac congestion in outpatient worsening heart failure (EVOLUTION)

European Journal of Heart Failure, Volume 27, Issue 2, Page 325-336, February 2025.
EVOLUTION study findings. KCCQ‐12, 12‐question Kansas City Cardiomyopathy Questionnaire; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide Abstract Aims We sought to characterize the clinical course of patients following worsening heart failure (WHF) treated in an outpatient setting and to identify factors associated with a poor response to standard
Gad Cotter, Beth Davison, Philip Janiak, Christopher Edwards, Maria Novosadova, Koji Takagi, Marie‐Laure Ozoux, Francesca Lawson, Hamlet Hayrapetyan, Hamayak Sisakian, Victor R. Ter‐Grigoryan, Katell Peoc'h, Alexandre Raynor, Paul Bruzeau, Alexis Nguyen, Alexandre Mebazaa   +15 more
wiley   +1 more source

Proapoptotic activity of new glutathione S-transferase inhibitors [PDF]

, 2005
Selected 7-nitro-2,1,3-benzoxadiazole derivatives have been recently found very efficient inhibitors of glutathione S-transferase (GST) PI-1,(5) an enzyme which displays antiapoptotic activity and is also involved in the cellular resistance to anticancer
Bullo, A, Caccuri, AM, Cerella, C, Cianfriglia, M, Ciriolo, MR, De Maria, F, Federici, G, Filomeni, G, Ghibelli, L, Mattei, M, Ricci, G, Turella, P   +11 more
core   +2 more sources

Synthesis and examination of 1,2,4‐triazine‐sulfonamide hybrids as potential inhibitory drugs: Inhibition effects on AChE and GST enzymes in silico and in vitro conditions

Archiv der Pharmazie, Volume 357, Issue 9, September 2024.
A series of 1,2,4‐triazine‐sulfonamide hybrids (3a–r) was synthesized and evaluated for their inhibitory effects on acetylcholinesterase (AChE) and glutathione S‐transferase (GST). The hybrids demonstrated promising inhibition of both AChE and GST activities.
Przemysław Rozbicki, Ercan Oğuz, Ewa Wolińska, Fikret Türkan, Adnan Cetin, Danuta Branowska   +5 more
wiley   +1 more source

Synthesis and spectroscopic/DFT structural characterization of coordination compounds of Nb(V) and Ti(IV) with bioactive carboxylic acids [PDF]

, 2018
The reactions are reported of NbX5(X = Cl, Br), TiCl4and Ti(OiPr)4with a selection of carboxylic acids exhibiting a known biological role, in a chlorinated solvent.
Alessandra Martini, Maria, Biancalana, Lorenzo, Bortoluzzi, Marco, De Palo, Alice, Marchetti, Fabio, Pampaloni, Guido   +5 more
core   +1 more source

A new mechanism of cancer initiation that involves the transformation of hepatocytes into preneoplastic single hepatocytes and minifoci positive for glutathione S‐transferase P‐form (GST‐P) in rat livers: 3D analysis using a vibratome

Cancer Medicine, Volume 13, Issue 18, September 2024.
A new mechanism of cancer initiation that involves the transformation of hepatocytes into preneoplastic single hepatocytes and minifoci positive for GST‐P was identified in the rat liver on the key finding of “rapid excretion of GST‐P into bile” obtained from 3D immunochemistry using a vibratome for the first time.
Kimihiko Satoh
wiley   +1 more source

Estimating the effect of diuretics and inhaled corticosteroids for evolving bronchopulmonary dysplasia in preterm infants

Paediatric and Perinatal Epidemiology, Volume 38, Issue 6, Page 495-504, August 2024.
Abstract Background Off‐label treatment of extremely preterm infants with diuretics and inhaled corticosteroids (ICS) for evolving bronchopulmonary dysplasia (BPD) is common. Their effectiveness in reducing mortality or BPD severity, and optimal treatment timing, are unclear.
Jonathan L. Slaughter, Mark A. Klebanoff, Erinn M. Hade   +2 more
wiley   +1 more source

In silico analysis of the molecular machinery underlying aqueous humor production: Potential implications for glaucoma [PDF]

, 2013
Background: The ciliary body epithelia (CBE) of the eye produce the aqueous humor (AH). The equilibrium between the AH production by the CBE and the outflow through the trabecular meshwork ultimately determines the intraocular pressure (IOP).
Bergen, A.A.B. (Arthur), Gorgels, T.G.M.F. (Theo), Jansonius, N.M. (Nomdo), Janssen, S.F. (Sarah), Spek, P.J. (Peter) van der   +4 more
core   +4 more sources