Results 41 to 50 of about 6,190 (242)

Proapoptotic activity of new glutathione S-transferase inhibitors [PDF]

, 2005
Selected 7-nitro-2,1,3-benzoxadiazole derivatives have been recently found very efficient inhibitors of glutathione S-transferase (GST) PI-1,(5) an enzyme which displays antiapoptotic activity and is also involved in the cellular resistance to anticancer
Bullo, A, Caccuri, AM, Cerella, C, Cianfriglia, M, Ciriolo, MR, De Maria, F, Federici, G, Filomeni, G, Ghibelli, L, Mattei, M, Ricci, G, Turella, P   +11 more
core   +2 more sources

Transport of 3-fluoro-l-α-methyl-tyrosine (FAMT) by organic ion transporters explains renal background in [18F]FAMT positron emission tomography

Journal of Pharmacological Sciences, 2016
A PET tracer for tumor imaging, 3-18F-l-α-methyl-tyrosine ([18F]FAMT), has advantages of high cancer-specificity and low physiological background. In clinical studies, FAMT-PET has been proved useful for the detection of malignant tumors and their ...
Ling Wei, Hideyuki Tominaga, Ryuichi Ohgaki, Pattama Wiriyasermkul, Kohei Hagiwara, Suguru Okuda, Kyoichi Kaira, Yukio Kato, Noboru Oriuchi, Shushi Nagamori, Yoshikatsu Kanai   +10 more
doaj   +1 more source

Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: Characteristics of non-enzymatic and glutathione S-transferase-mediated reactions

Journal of Pharmaceutical Analysis, 2021
Unsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. A significant route of phase II drug metabolism is conjugation with glutathione (GSH), which can be non-enzymatic and/or catalyzed by GSH-dependent enzymes.
Agnieszka Potęga, Michał Kosno, Zofia Mazerska   +2 more
doaj   +1 more source

In silico analysis of the molecular machinery underlying aqueous humor production: Potential implications for glaucoma [PDF]

, 2013
Background: The ciliary body epithelia (CBE) of the eye produce the aqueous humor (AH). The equilibrium between the AH production by the CBE and the outflow through the trabecular meshwork ultimately determines the intraocular pressure (IOP).
Bergen, A.A.B. (Arthur), Gorgels, T.G.M.F. (Theo), Jansonius, N.M. (Nomdo), Janssen, S.F. (Sarah), Spek, P.J. (Peter) van der   +4 more
core   +5 more sources

Contrast-Associated Acute Kidney Injury Requiring Continuous Renal Replacement Therapy in A Neonate with Aortic Stenosis—A Case Report

Pediatric Reports, 2023
Background: Acute kidney injury occurs commonly in the Neonatal Intensive Care Unit and is associated with increased mortality and morbidity. We report a case of a neonate with congenital heart disease who developed acute kidney injury after cardiac ...
Catalin Cirstoveanu, Carmina Georgescu, Nicolae Ruxandra, Mihaela Bizubac, Eliza Cinteza, Corina Maria Vasile, Cristina Filip, Irina Margarint   +7 more
doaj   +1 more source

Ouabain-induced cytoplasmic vesicles and their role in cell volume maintenance [PDF]

, 2015
Cellular swelling is controlled by an active mechanism of cell volume regulation driven by a Na+/K+-dependent ATPase and by aquaporins which translocate water along the osmotic gradient. Na+/K+-pump may be blocked by ouabain, a digitalic derivative, by
MORGANTE, Emanuela, Rossum, G. D. Van, Russo, A., RUSSO, Matteo Antonio, TAFANI, MARCO   +4 more
core   +1 more source

Expression proteomics study to determine metallodrug targets and optimal drug combinations

Scientific Reports, 2017
The emerging technique termed functional identification of target by expression proteomics (FITExP) has been shown to identify the key protein targets of anti-cancer drugs. Here, we use this approach to elucidate the proteins involved in the mechanism of
Ronald F. S. Lee, Alexey Chernobrovkin, Dorothea Rutishauser, Claire S. Allardyce, David Hacker, Kai Johnsson, Roman A. Zubarev, Paul J. Dyson   +7 more
doaj   +1 more source

Molecular characterisation of Entamoeba histolytica UDP-glucose 4-epimerase, an enzyme able to provide building blocks for cyst wall formation.

PLoS Neglected Tropical Diseases, 2023
In the human host, the protozoan parasite Entamoeba histolytica is adapted to a non-invasive lifestyle in the colon as well as to an invasive lifestyle in the mesenterial blood vessels and the liver.
Anna Nagode, Jorick Vanbeselaere, Zuzanna Dutkiewicz, Samantha Kaltenbrunner, Iain B H Wilson, Michael Duchêne   +5 more
doaj   +1 more source

Cellular pharmacokinetic and pharmacodynamic analyses of ethacrynic acid: Implications in topical drug delivery in the eye. [PDF]

Mol Vis, 2011
Lin CW, Gonzalez P, Yuan F.
europepmc   +2 more sources

Exploring molecular structure (monomer & dimer), spectroscopic (FT-IR, FT-Raman, UV-Vis, NMR), TG/DTA, antibacterial and molecular docking investigation on 2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy] acetic acid by DFT and wavefunction analysis

Chemical Physics Impact
The present work focused on molecular structure and various spectroscopic studies of 2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy] acetic acid is also called as Ethacrynic acid (EA).
S. Asokan, S. Sebastian, B. Karthikeyan, S. Xavier, R. Ganapathi Raman, S. Silvan, S. Sangeetha Margreat, R. Sagayaraj   +7 more
doaj   +1 more source