Results 41 to 50 of about 4,746 (159)

Unlocking mitochondrial drug targets: The importance of mitochondrial transport proteins

Acta Physiologica, Volume 240, Issue 6, June 2024.
Abstract A disturbed mitochondrial function contributes to the pathology of many common diseases. These organelles are therefore important therapeutic targets. On the contrary, many adverse effects of drugs can be explained by a mitochondrial off‐target effect, in particular, due to an interaction with carrier proteins in the inner membrane.
Charlotte A. Hoogstraten, Tom J. J. Schirris, Frans G. M. Russel   +2 more
wiley   +1 more source

Biochemical characterization and gene structure analysis of the 24‐kDa glutathione transferase sigma from Taenia solium

FEBS Open Bio, Volume 14, Issue 5, Page 726-739, May 2024.
Glutathione transferases (GST) are involved in detoxification and immunomodulation, allowing the establishment and development of cestodes in the host. Taenia solium has a 24‐kDa GST sigma class inducible gene that encodes a stable enzyme in a wide range of pHs and temperatures. Its enzymatic activity differs from other GSTs in the parasite, suggesting
Ricardo Miranda‐Blancas, Oscar Rodríguez‐Lima, Ponciano García‐Gutiérrez, Roberto Flores‐López, Lucía Jiménez, Rafael A. Zubillaga, Enrique Rudiño‐Piñera, Abraham Landa   +7 more
wiley   +1 more source

Identification of PPAR‐related differentially expressed genes liver hepatocellular carcinoma and construction of a prognostic model based on data analysis and molecular docking

Journal of Cellular and Molecular Medicine, Volume 28, Issue 8, April 2024.
Abstract Liver hepatocellular carcinoma (LIHC) is a significant global health issue with limited treatment options. In this study, single‐cell RNA sequencing (scRNA‐seq) data were used to explore the molecular mechanisms of LIHC development and identify potential targets for therapy.
Yumeng Wang, Shuqiang Li, Zihang Liu, Xuanzheng Li, Yifan Yu, Hao Liu   +5 more
wiley   +1 more source

Priprava uzoraka i određivanje diuretika u tjelesnim tekućinama čovjeka pomoću RPHPLC [PDF]

, 2006
This article described reverse phase high-performance liquid chromatography (RPHPLC) methods for determination of diuretics in different human body fluids (whole blood, plasma, serum or urine).
DRAGICA ZENDELOVSKA, TRAJČE STAFILOV
core   +1 more source

Busulfan induces steatosis in HepaRG cells but not in primary human hepatocytes: Possible explanations and implication for the prediction of drug‐induced liver injury

Fundamental &Clinical Pharmacology, Volume 38, Issue 1, Page 152-167, February 2024.
Abstract Background The antineoplastic drug busulfan can induce different hepatic lesions including cholestasis and sinusoidal obstruction syndrome. However, hepatic steatosis has never been reported in patients. Objectives This study aimed to determine whether busulfan could induce steatosis in primary human hepatocytes (PHH) and differentiated HepaRG
Julien Allard, Simon Bucher, Pierre‐Jean Ferron, Youenn Launay, Bernard Fromenty   +4 more
wiley   +1 more source

The potential of mid-infrared photoacoustic spectroscopy for the detection of various doping agents used by athletes [PDF]

, 2018
The feasibility of laser-photoacoustic measurements for the detection and the analysis of different isolated doping agents in the vapour phase is discussed. To the best of our knowledge, this is the first time that photoacoustic vapour-phase measurements
Bartlome, R., Fischer, C., Sigrist, M.W.
core  

A novel method for screening the glutathione transferase inhibitors [PDF]

, 2009
Background Glutathione transferases (GSTs) belong to the family of Phase II detoxification enzymes. GSTs catalyze the conjugation of glutathione to different endogenous and exogenous electrophilic compounds.
Jin, Li, Wang, Zhijun, Węgrzyn, Alicja, Węgrzyn, Grzegorz   +3 more
core   +4 more sources

Increased nitric oxide activity compensates for increased oxidative stress to maintain endothelial function in rat aorta in early type 1 diabetes [PDF]

, 2012
Hyperglycaemia and oxidative stress are known to acutely cause endothelial dysfunction in vitro, but in the initial stages of diabetes, endothelium-dependent relaxation is preserved.
Joshi, A, Woodman, O
core   +1 more source

Partial Purification and Characterization of Glutathione S-Transferases from Kedah-Kelantan Cattle (Bos Indicus) and Water Buffalo (Bubalus Bubalis) Liver [PDF]

, 2006
Biotransformation and detoxification process in living organisms consists of two phases, phase I and phase 11. Phase I involves in the introduction of functional group into molecule while the phase I1 involves the conjugation of phase I metabolites. In
Saleh Huddin, Lailatul Jumaiyah
core  

Substrate specificites of cytosolic glutathione-S transferases in five different species of the aquatic macrophyte Myriophyllum [PDF]

, 2005
We report about the general biotransformation activity based on the activities of glutathione S-transferases (GST\u27s; EC 2.5.1.18) on different model substrates, of five species of the macrophyte genera Myriophyllum (M. hippuroides, M.
Nimptsch, Jorge, Pflugmacher, Stephan
core   +2 more sources