Results 51 to 60 of about 6,190 (242)

Alpha-class glutathione S-transferases in wild turkeys (Meleagris gallopavo): characterization and role in resistance to the carcinogenic mycotoxin aflatoxin B1. [PDF]

PLoS ONE, 2013
Domestic turkeys (Meleagris gallopavo) are one of the most susceptible animals known to the toxic effects of the mycotoxin aflatoxin B1 (AFB1), a potent human hepatocarcinogen, and universal maize contaminant.
Ji Eun Kim, Brett R Bunderson, Amanda Croasdell, Kent M Reed, Roger A Coulombe   +4 more
doaj   +1 more source

Predictors of a Gabapentinoid–Loop‐Diuretic Prescribing Cascade in U.S. Nursing Home Residents

Journal of the American Geriatrics Society, EarlyView.
Among 23,544 older adult long‐stay nursing home residents who initiated a gabapentinoid in the nursing home (2016–2022), 4.2% experienced a loop diuretic prescribing cascade within 90 days. Predictors of the prescribing cascade included older age, higher medication burden (≥ 15 medications), current receipt of non‐loop diuretics, and titration of ...
Kaleen N. Hayes, Emmanuelle Belanger, Arman Oganisian, Richa Joshi, Xiao (Joyce) Wang, Lexie R. Grove, Kelsey L. Corcoran, Andrew R. Zullo   +7 more
wiley   +1 more source

Biological significance of glutathione S-transferases in human sperm cells

Journal of Human Reproductive Sciences, 2019
Background: Oxidative stress is considered as one of the causes of male subfertility or infertility. Among antioxidant enzymes, the crucial role belongs to glutathione S-transferases (GSTs).
Roman V Fafula, Nataliya M Paranyak, Anna S Besedina, Dmytro Z Vorobets, Ulyana P Iefremova, Olena K Onufrovych, Zinoviy D Vorobets   +6 more
doaj   +1 more source

Members of the chloride intracellular ion channel protein family demonstrate glutaredoxin-like enzymatic activity [PDF]

, 2015
© 2015 Al Khamici et al. The Chloride Intracellular Ion Channel (CLIC) family consists of six evolutionarily conserved proteins in humans. Members of this family are unusual, existing as both monomeric soluble proteins and as integral membrane proteins ...
Brown, LJ, Cornell, BA, Curmi, PMG, Daniel, EL, Davey, MW, Hare, JE, Hossain, KR, Hudson, AL, Khamici, HA, Ng, JPM, Sinclair-Burton, AA, Valenzuela, SM   +11 more
core   +1 more source

Characterization of Affinity-Purified Isoforms of Acinetobacter calcoaceticus Y1 Glutathione Transferases

The Scientific World Journal, 2014
Glutathione transferases (GST) were purified from locally isolated bacteria, Acinetobacter calcoaceticus Y1, by glutathione-affinity chromatography and anion exchange, and their substrate specificities were investigated.
Chin-Soon Chee, Irene Kit-Ping Tan, Zazali Alias   +2 more
doaj   +1 more source

Preparation of GST Inhibitor Nanoparticle Drug Delivery System and Its Reversal Effect on the Multidrug Resistance in Oral Carcinoma

Nanomaterials, 2015
During the chemotherapy of cancer, drug resistance is the first issue that chemotherapeutic drugs cannot be effectively used for the treatment of cancers repeatedly for a long term, and the main reason for this is that tumor cell detoxification is ...
Bing Han, Yanli Wang, Lan Wang, Zuhui Shang, Shuang Wang, Jin Pei   +5 more
doaj   +1 more source

Clinical profiles and prognostic impact of residual intravascular and tissue congestion in acute heart failure

European Journal of Heart Failure, Volume 27, Issue 12, Page 3123-3133, December 2025.
This study investigated the prognostic value of residual congestion phenotypes at discharge in acute heart failure. Patients with intravascular residual congestion had better diuretic responses and shorter hospital stays than those with tissue/combined residual congestion, but worse outcomes than decongested patients.
Daan C.H. Ceelen, Jozine M. ter Maaten, Geert H.D. Voordes, Gad Cotter, Beth A. Davison, Gerasimos Filippatos, Peter S. Pang, Claudio Gimpelewicz, John G.F. Cleland, G. Michael Felker, Barry Greenberg, Michael M. Givertz, Christopher M. O'Conner, John R. Teerlink, Marco Metra, Adriaan A. Voors   +15 more
wiley   +1 more source

Design, Synthesis, and Evaluation of EA-Sulfonamides and Indazole-Sulfonamides as Promising Anticancer Agents: Molecular Docking, ADME Prediction, and Molecular Dynamics Simulations

Chemistry
New EA-sulfonamides and indazole-sulfonamides were synthesized, characterized, and evaluated for their anticancer activities. The target compound structures were elucidated using various spectroscopic techniques such as NMR-{1H and 13C}, infrared ...
Nassima Saghdani, Nabil El Brahmi, Abdelmoula El Abbouchi, Rachid Haloui, Souad Elkhattabi, Gérald Guillaumet, Saïd El Kazzouli   +6 more
doaj   +1 more source

Advances in Inhaled Nanoparticle Drug Delivery for Pulmonary Disease Management

The FASEB Journal, Volume 39, Issue 21, 15 November 2025.
Pulmonary disorders remain a global health challenge. This review explores critical innovations in inhaled nanoparticle drug delivery systems focusing on their potential to revolutionize treatment strategies for a wide spectrum of pulmonary diseases. We highlight recent breakthroughs in carrier materials, performance evaluations in vitro and in vivo ...
Yunzhou Fan, Yuefang Zhou, Jing Zhao, Yutong Zhao   +3 more
wiley   +1 more source

Biochemical characterization and peptide mass fingerprinting of two glutathione transferases from Biomphalaria alexandrina snails (Gastropoda: Planorbidae)

Journal of Genetic Engineering and Biotechnology, 2022
Background The freshwater snails Biomphalaria alexandrina (Gastropoda: Planorbidae) has public health importance of being an intermediate host of Schistosoma mansoni, the parasite species that causes intestinal schistosomiasis in humans.
Abdel-Monem Abdalla, Ghada S. A. Abdel Karim   +1 more
doaj   +1 more source