Results 61 to 70 of about 6,190 (242)

The Pharmacology of Newer Diuretics [PDF]

, 1967
There are now a number of different classes of diuretics with different pharmacologic effects. Several considerations dictate the choice of diuretic: 1. The responsiveness of the patient is of prime importance. If the patient is not known to be resistant
Wasserman, Albert J.
core   +1 more source

Maternal Exposure to Medications and the Risk of Congenital and Early‐Onset Hearing Loss in Children: A Systematic Review and a Meta‐Analysis

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 3, September 2025.
ABSTRACT Background Congenital hearing loss (CHL) affects approximately 1–2 in 1000 children and significantly impacts development. Exposure to medications during pregnancy may impact offspring hearing; however, the ototoxic effects of different drugs have not been systematically investigated.
Asli Sena Kücükyildiz, Mette Østergaard Thunbo, Christer Zøylner Swan, David P. Burgner, Jessica E. Miller, Therese Ovesen, Lars Henning Pedersen   +6 more
wiley   +1 more source

Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies

Neurobiology of Disease, 2012
TAR DNA-binding protein 43 (TDP-43) is a major component of ubiquitin-positive inclusion of TDP-43 proteinopathies including amyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitinated inclusions, which is now referred to as ...
Yohei Iguchi, Masahisa Katsuno, Shinnosuke Takagi, Shinsuke Ishigaki, Jun-ichi Niwa, Masato Hasegawa, Fumiaki Tanaka, Gen Sobue   +7 more
doaj   +1 more source

Priprava uzoraka i određivanje diuretika u tjelesnim tekućinama čovjeka pomoću RPHPLC [PDF]

, 2006
This article described reverse phase high-performance liquid chromatography (RPHPLC) methods for determination of diuretics in different human body fluids (whole blood, plasma, serum or urine).
DRAGICA ZENDELOVSKA, TRAJČE STAFILOV
core   +1 more source

Nano-hole induction by nanodiamond and nanoplatinum liquid, DPV576, reverses multidrug resistance in human myeloid leukemia (HL60/AR). [PDF]

, 2013
Recently nanoparticles have been extensively studied and have proven to be a promising candidate for cancer treatment and diagnosis. In the current study, we examined the chemo-sensitizing activity of a mixture of nanodiamond (ND) and nanoplatinum (NP ...
Ghoneum, Alia, Gimzewski, James, Sharma, Shivani   +2 more
core   +2 more sources

Unraveling the functional dynamics of Caenorhabditis elegans stress‐responsive omega class GST‐44

The FEBS Journal, Volume 292, Issue 17, Page 4675-4693, September 2025.
Omega‐class glutathione S‐transferases (GSTs) are integral to redox regulation and cellular stress responses. This study characterized GST‐44 in Caenorhabditis elegans, revealing its predominant expression in the intestine and excretory H‐cell, with significant upregulation under various stress conditions.
Charlotte Sophia Kaiser, Milena Lubisch, Emma Schröder, Luka Ressmann, Marie Nicolaus, Dustin Leusder, Sven Moyzio, Robert Peuss, Antonio Miranda‐Vizuete, Eva Liebau   +9 more
wiley   +1 more source

Bivalent Enzyme Inhibitors Discovered Using Dynamic Covalent Chemistry [PDF]

, 2012
A bivalent dynamic covalent chemistry (DCC) system has been designed to selectively target members of the homodimeric glutathione-S-transferase (GST) enzyme family.
Ang, Appiah-Opong, Beeren, Beeren, Beeren, Bhat, Bhat, Blanden, Bunyapaiboonsri, Bunyapaiboonsri, Carroll, Cheng, Cho, Corbett, Corbett, Corbett, Cordes, Cousins, Deng, Dirksen, Dorion, Erlanson, Federici, Furlan, Gromova, Habig, Hayes, Hochgürtel, Huc, Jao, Li, Lins, Liu, Liénard, Liénard, Lyon, Maeda, Mahajan, Mannervik, McIlwain, Oakley, Oakley, Oakley, Patskovsky, Poulsen, Poulsen, Ralat, Ramström, Ramström, Roberts, Romieu, Ryoo, Sampsonas, Severin, Sheehan, Shi, Simpson, Simpson, Son, Townsend, Tsuboi, Woon, Xue, Zameo, Zameo   +64 more
core   +1 more source

Recent advances in the structure, function and regulation of the volume‐regulated anion channels and their role in immunity

The Journal of Physiology, Volume 603, Issue 15, Page 4255-4291, 1 August 2025.
Abstract figure legend The volume‐regulated anion channel (VRAC), composed of leucine‐rich repeat‐containing 8 (LRRC8) proteins, serves both canonical and non‐canonical functions in vertebrate cells. The canonical function of this channel relates to its original description, which is homeostatic regulation of cell volume in response to hypotonic ...
Sergei Yanushkevich, Aleksandra Zieminska, Joshua Gonzalez, Francisca Añazco, Richard Song, Alejandra Arias‐Cavieres, Sara T. Granados, Junyi Zou, Yan Rao, Axel R. Concepcion   +9 more
wiley   +1 more source

Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia [PDF]

, 2016
[Background] Mutations in the progranulin gene (GRN) are the most common cause of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). TDP-43 pathology is characterized by the hyperphosphorylation of the protein at Serine
Carolina Alquezar, Irene G. Salado, Ana de la Encarnación, Daniel I. Pérez, Fermín Moreno, Carmen Gil, Adolfo López de Munain, Ana Martínez, Ángeles Martín-Requero   +8 more
core   +1 more source

Canagliflozin reduces oral loop diuretic intensification in patients with type 2 diabetes: A participant‐level pooled analysis of the CANVAS and CREDENCE trials

European Journal of Heart Failure, Volume 27, Issue 6, Page 994-1002, June 2025.
Among high‐risk patients with type 2 diabetes, new oral loop diuretic intensification was frequent and portended adverse prognostic significance. Treatment with canagliflozin significantly reduced the need for loop diuretic intensification. CI, confidence interval; CKD, chronic kidney disease; CV, cardiovascular; HF, heart failure; HR, hazard ratio ...
Safia Chatur, Muthiah Vaduganathan, Robert A. Fletcher, Vlado Perkovic, Hiddo Heerspink, Clare Arnott, Carol Pollock, Kenneth W. Mahaffey, Bruce Neal, Meg Jardine, Scott D. Solomon, Brendon L. Neuen   +11 more
wiley   +1 more source