Results 71 to 80 of about 6,190 (242)
Synthesis and Study of 2‑(Pyrrolesulfonylmethyl)‑N‑arylimines: A New Class of Inhibitors for Human Glutathione Transferase A1‑1 [PDF]
, 2012 Overexpression of human GSTA1-1 in tumor cells is part of MDR mechanisms. We report on the synthesis of 11 pyrrole derivatives as hGSTA1-1 inhibitors starting from 1-methyl-2-[(2-nitrobenzylsulfanyl]-1H-pyrrole.
Clonis, Yannis D. +6 more
core +1 more source
Neuropathology, Volume 45, Issue 3, Page 177-201, June 2025.Oxidative stress in sporadic amyotrophic lateral sclerosis (ALS) has been evidenced by accumulation of oxidatively modified products of nucleic acids, lipids, sugars, and proteins in the motor neuron system of brains and spinal cords obtained at autopsy from the patients.
Noriyuki Shibata +6 more
wiley +1 more source
Ethacrynic Acid Induced Inotropism
Experimental Biology and Medicine, 1975 Ethacrynic acid (ECA), a sulfhydryl group inhibiting diuretic was examined for positive inotropic effects. These were found to be present in isolated guinea pig left atria studied in 0.9 and 1.8 mM Ca bathing solutions and were partially dependent upon adrenergic mechanisms (presumably secondary to norepinephrine release from sympathetic nerve endings)
A H, From, J L, Probstfield, T R, Smith
openaire +2 more sources
Hypotensive Effect of Ethacrynic Acid [PDF]
Circulation, 1965 Ethacrynic acid has been found to possess a similar antihypertensive action to the thiazide diuretics. The use of the two drugs together results in a greater fall in pressure than that obtained with either drug alone. When thiazide therapy is supplemented by ethacrynic acid and dietary restriction of sodium a substantial additional reduction in blood ...
J, CONWAY, G, LEONETTI
openaire +2 more sources
Advanced Science, Volume 12, Issue 6, February 10, 2025.Inspired by the structure and reciprocating motion of fish dorsal fins, a drug‐eluting contact lens based on deformable microstructures for non‐invasive drug delivery is developed. The drug release rate can be adaptively adjusted to intraocular pressure changes and proactively regulated by cyclic ocular loads, enabling it to respond to elevated ...
Xu Li +9 more
wiley +1 more source
Toxicology Reports, 2016 Fish hepatic glutathione transferases are connected with the elimination of intracellular pollutants and detoxification of organic micro-pollutants in their aquatic ecosystem. The two-substrate steady state kinetic mechanism of Silver catfish (Synodontis
Ayodele O. Kolawole
doaj +1 more source
The MALDI TOF E2/E3 ligase assay as universal tool for drug discovery in the ubiquitin pathway [PDF]
, 2017 In many diseases, components of the ubiquitin system - such as E2/E3 ligases and deubiquitylases - are dysregulated. The ubiquitin system has therefore become an emergent target for the treatment of a number of diseases, including cancer ...
Barlow, Victoria +5 more
core +5 more sources
European Journal of Heart Failure, Volume 27, Issue 2, Page 325-336, February 2025.EVOLUTION study findings. KCCQ‐12, 12‐question Kansas City Cardiomyopathy Questionnaire; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide Abstract Aims We sought to characterize the clinical course of patients following worsening heart failure (WHF) treated in an outpatient setting and to identify factors associated with a poor response to standard
Gad Cotter +15 more
wiley +1 more source
Blood Advances, 2017 : Besides being a classical tumor suppressor, runt-related transcription factor 1 (RUNX1) is now widely recognized for its oncogenic role in the development of acute myeloid leukemia (AML).
Ken Morita +8 more
doaj +1 more source
Archiv der Pharmazie, Volume 357, Issue 9, September 2024.A series of 1,2,4‐triazine‐sulfonamide hybrids (3a–r) was synthesized and evaluated for their inhibitory effects on acetylcholinesterase (AChE) and glutathione S‐transferase (GST). The hybrids demonstrated promising inhibition of both AChE and GST activities.
Przemysław Rozbicki +5 more
wiley +1 more source