Results 31 to 40 of about 22,847 (294)
Ether à go-go Potassium Channels as Human Cervical Cancer Markers [PDF]
Cancer Research, 2004 Abstract Ether à go-go (EAG) potassium channels display oncogenic properties. In normal tissues, EAG mRNA is almost exclusively expressed in brain, but it is expressed in several somatic cancer cell lines, including HeLa, from cervix. Antisense experiments against eag reduce cell proliferation in some cancer cell lines, and inhibition ...
Fernando Larrea +19 more
openaire +3 more sources
Cloning of a human ether‐a‐go‐go potassium channel expressed in myoblasts at the onset of fusion [PDF]
FEBS Letters, 1998 An early sign of human myoblast commitment to fusion is the expression of a non‐inactivating delayed rectifier K+ current, IK(NI), and an associated membrane potential hyperpolarization. We have isolated the full‐length coding region of a human ether‐a‐go‐go K+ channel (h‐eag) from myoblasts undergoing differentiation.
Occhiodoro, T. +6 more
openaire +4 more sources
Key role for Kv11.1 (ether‐a‐go‐go related gene) channels in rat bladder contractility
Physiological Reports, 2023 In addition, to their established role in cardiac myocytes and neurons, ion channels encoded by ether‐a‐go‐go‐related genes (ERG1‐3 or kcnh2,3 and 6) (kcnh2) are functionally relevant in phasic smooth muscle.
Vincenzo Barrese +7 more
doaj +1 more source
Micromachines, 2021 The reconstitution of ion-channel proteins in artificially formed bilayer lipid membranes (BLMs) forms a well-defined system for the functional analysis of ion channels and screening of the effects of drugs that act on these proteins.
Ryusuke Miyata +9 more
doaj +1 more source
Kv7 and Kv11 channels in myometrial regulation. [PDF]
, 2013 Ion channels play a key role in defining myometrial contractility. Modulation of ion channel populations is proposed to underpin gestational changes in uterine contractility associated with the transition from uterine quiescence to active labour.
Iain A. Greenwood +3 more
core +2 more sources
Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells. [PDF]
PLoS ONE, 2017 The human ether-a-go-go-related gene (hERG) potassium channel conducts rapid delayed rectifier potassium currents (IKr) and contributes to phase III cardiac action potential repolarization.
Dahai Yu +8 more
doaj +1 more source
Analysis of ether-à-go-go potassium channel (Eag1) splice variants in melanoma cells [PDF]
, 2011 Fernanda Ramos Gomes
openalex +3 more sources
Blockade of the Human Ether A-Go-Go–Related Gene (hERG) Potassium Channel by Fentanyl [PDF]
Molecular Pharmacology, 2019 The human ether-a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel (IKr). Drug-mediated or medical condition-mediated disruption of hERG function is the primary cause of acquired long-QT syndrome, which predisposes affected individuals to ventricular arrhythmias and sudden death ...
Wentao Li +3 more
openaire +3 more sources
Frontiers in Pharmacology, 2020 EAG (ether-à-go-go or KCNH) are a subfamily of the voltage-gated potassium (Kv) channels. Like for all potassium channels, opening of EAG channels drives the membrane potential toward its equilibrium value for potassium, thus setting the resting ...
Francisco Barros +4 more
doaj +1 more source
Biophysics and Physicobiology, 2023 The evaluation of the inhibitory activities of drugs on multiple cardiac ion channels is required for the accurate assessment of proarrhythmic risks.
Tatsuki Negami, Tohru Terada
doaj +1 more source