Results 61 to 70 of about 30,487 (240)

Cardiac Potassium Channels: Physiological Insights for Targeted Therapy. [PDF]

, 2017
The development of novel drugs specifically directed at the ion channels underlying particular features of cardiac action potential (AP) initiation, recovery, and refractoriness would contribute to an optimized approach to antiarrhythmic therapy that ...
A. John Camm, Christopher L.-H. Huang, Feng J, Hansen RS, Kamalan Jeevaratnam, Karan R. Chadda, Lepran I, Milnes JT, Nichols CG, Rampe D, Rampe D, Shieh CC, Wang Z, Zhao X, Zhou J   +14 more
core   +1 more source

A minK-HERG complex regulates the cardiac potassium current I(Kr). [PDF]

, 1997
MinK is a widely expressed protein of relative molecular mass approximately 15K that forms potassium channels by aggregation with other membrane proteins.
Fishman, GI, Goldstein, SA, McDonald, TV, Meyers, MB, Ming, Z, Palma, E, Wang, KW, Yu, Z   +7 more
core  

Gain of function mutants: Ion channels and G protein-coupled receptors [PDF]

, 2000
Many ion channels and receptors display striking phenotypes for gain-of-function mutations but milder phenotypes for null mutations. Gain of molecular function can have several mechanistic bases: selectivity changes, gating changes including constitutive
Karschin, Andreas, Lester, Henry A.
core   +1 more source

APETx4, a novel sea anemone toxin and a modulator of the cancer-relevant potassium channel K_V10.1 [PDF]

, 2017
The human ether-à-go-go channel (hEag1 or KV10.1) is a cancer-relevant voltage-gated potassium channel that is overexpressed in a majority of human tumors. Peptides that are able to selectively inhibit this channel can be lead compounds in the search for
Béress, L., De Pauw, E., Galan, D.T., Moreels, L., Pardo, L.A., Peigneur, S., Quinton, L., Tytgat, J., Waelkens, E.   +8 more
core  

Electrophysiological analysis of mammalian cells expressing hERG using automated 384-well-patch-clamp [PDF]

, 2015
BACKGROUND: An in vitro electrophysiological assay system, which can assess compound effects and thus show cardiotoxicity including arrhythmia risks of test drugs, is an essential method in the field of drug development and toxicology.
Atsushi, Ohtsuki, Haraguchi, Yuji, Shimizu, Tatsuya, Takayuki, Oka   +3 more
core   +2 more sources

Potassium channels in C. elegans [PDF]

, 2005
Ion channels are the "transistors" (electronic switches) of the brain that generate and propagate electrical signals in the aqueous environment of the brain and nervous system. Potassium channels are particularly important because, not only do they shape
Baban, Beravan, Butler, Alice, Fawcett, Gloria L, Ferreira, Gonzalo, Salkoff, Lawrence B, Santi, Celia M, Wei, Aguan   +6 more
core   +2 more sources

Voltage-dependent gating of hERG potassium channels

Frontiers in Pharmacology, 2012
The mechanisms by which voltage-gated channels sense changes in membrane voltage and energetically couple this with opening of the ion conducting pore has been the source of significant interest.
Yen May eCheng, Tom W Claydon
doaj   +1 more source

Risk of QTc Interval Prolongation Associated With Circulating Anti‐Ro/SSA Antibodies Among US Veterans: An Observational Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Anti‐Sjögren's syndrome‐related antigen A‐antibodies (anti‐Ro/SSA‐antibodies) are responsible for a novel form of acquired long‐QT syndrome, owing to autoimmune‐mediated inhibition of cardiac human ether‐a‐go‐go‐related gene‐potassium channels.
Pietro Enea Lazzerini, Gabriele Cevenini, Yongxia Sarah Qu, Frank Fabris, Nabil El‐Sherif, Maurizio Acampa, Alessandra Cartocci, Franco Laghi‐Pasini, Pier Leopoldo Capecchi, Mohamed Boutjdir, Deana Lazaro   +10 more
doaj   +1 more source

Targeting the Ether-à-go-go ion channels in cancer therapy: current knowledge and future perspectives

Journal of Experimental and Molecular Biology, 2018
Members of the Ether-à-go-go (Eag) group of potassium channels, including the human Ether-à-go-go (hEag) and the human Ether-à-go-go-related gene (hERG) ion channels, have been shown to play important roles in cancer pathogenesis and to regulate many ...
Daniel Şterbuleac, Dumitru Cojocaru
doaj  

Electrophysiological characterization of a small molecule activator on human ether-a-go-go-related gene (hERG) potassium channel

Journal of Pharmacological Sciences, 2019
The human ether-a-go-go-related gene (hERG) encodes the K+ channel that carries the rapid component of the delayed rectifier current in the human heart. Reduction of hERG activity induced by gene mutations or pharmacological inhibition is responsible for the type 2 form of long QT syndrome in patients which can develop into ventricular arrhythmia and ...
Xiuming Dong, Yani Liu, Heling Niu, Gongxin Wang, Liying Dong, Anruo Zou, KeWei Wang   +6 more
openaire   +3 more sources