Results 61 to 70 of about 22,847 (294)

In silico mechanisms of arsenic trioxide-induced cardiotoxicity

Frontiers in Physiology, 2022
It has been found that arsenic trioxide (ATO) is effective in treating acute promyelocytic leukemia (APL). However, long QT syndrome was reported in patients receiving therapy using ATO, which even led to sudden cardiac death.
Yacong Li, Runlan Wan, Jun Liu, Jun Liu, Weichao Liu, Lei Ma, Lei Ma, Henggui Zhang   +7 more
doaj   +1 more source

Expression of the ether-a-gò-gò-related gene 1 channel during B and T lymphocyte development: role in BCR and TCR signaling

Frontiers in Immunology, 2023
The functional relevance of K+ and Ca2+ ion channels in the “Store Operated Calcium Entry” (SOCE) during B and T lymphocyte activation is well proven. However, their role in the process of T- and B- cell development and selection is still poorly defined.
Cesare Sala, Martina Staderini, Tiziano Lottini, Claudia Duranti, Gabriele Angelini, Gabriela Constantin, Annarosa Arcangeli   +6 more
doaj   +1 more source

The environmental toxicant ziram enhances neurotransmitter release and increases neuronal excitability via the EAG family of potassium channels

Neurobiology of Disease, 2020
Environmental toxicants have the potential to contribute to the pathophysiology of multiple complex diseases, but the underlying mechanisms remain obscure.
Jenna Harrigan, Daisy F. Brambila, Pratap Meera, David E. Krantz, Felix E. Schweizer   +4 more
doaj  

14-3-3θ is a binding partner of rat Eag1 potassium channels. [PDF]

PLoS ONE, 2012
The ether-à-go-go (Eag) potassium (K(+)) channel belongs to the superfamily of voltage-gated K(+) channel. In mammals, the expression of Eag channels is neuron-specific but their neurophysiological role remains obscure.
Po-Hao Hsu, Shi-Chuen Miaw, Chau-Ching Chuang, Pei-Yu Chang, Ssu-Ju Fu, Guey-Mei Jow, Mei-Miao Chiu, Chung-Jiuan Jeng   +7 more
doaj   +1 more source

Computational modelling of the pro- and antiarrhythmic effects of atrial high rate-dependent trafficking of small-conductance calcium-activated potassium channels. [PDF]

J Physiol
Abstract figure legend Small‐conductance calcium‐activated potassium (SK) channels are important for atrial repolarization and can be targeted for atrial‐specific antiarrhythmic treatments. We developed a computational model with a calcium sensor to study the effects of increased pacing rate (5 Hz), which enhances SK‐channel gating and forward ...
Meier S, Dobrev D, Volders PGA, Heijman J.   +3 more
europepmc   +2 more sources

The contribution of Kv7 channels to pregnant mouse and human myometrial contractility. [PDF]

, 2010
Premature birth accounts for approximately 75% of neonatal mortality and morbidity in the developed world. Despite this, methods for identifying and treating women at risk of preterm labour are limited and many women still present in preterm labour ...
England, SK, Greenwood, IA, McCallum, LA, Pierce, SL, Tribe, RM   +4 more
core   +1 more source

Ultrasoft Iontronics: Stretchable Diodes Enabled by Ionically Conductive Bottlebrush Elastomers

Advanced Functional Materials, EarlyView.
This work introduces a solvent‐free, ultrasoft, and stretchable ionic diode based on oppositely charged bottlebrush elastomers (BBEs). The BBE diode exhibits an ultralow Young's modulus (<23 kPa), a high rectification ratio of 46, and stretchability over 400%.
Xia Wu, Pengfei Xu, Zefang Zhang, Qi Yang, Xi Huang, Peng Pan, Xinyu Liu   +6 more
wiley   +1 more source

A companion to the preclinical common data elements for proteomics, lipidomics, and metabolomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines.
Laura Bindila, Tore Eid, James D. Mills, Michael S. Hildebrand, Gary P. Brennan, Susan A. Masino, Vicky Whittemore, Piero Perucca, Christopher A. Reid, Manisha Patel, Kevin K. Wang, Erwin A. van Vliet   +11 more
wiley   +1 more source

Risk of QTc Interval Prolongation Associated With Circulating Anti‐Ro/SSA Antibodies Among US Veterans: An Observational Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Anti‐Sjögren's syndrome‐related antigen A‐antibodies (anti‐Ro/SSA‐antibodies) are responsible for a novel form of acquired long‐QT syndrome, owing to autoimmune‐mediated inhibition of cardiac human ether‐a‐go‐go‐related gene‐potassium channels.
Pietro Enea Lazzerini, Gabriele Cevenini, Yongxia Sarah Qu, Frank Fabris, Nabil El‐Sherif, Maurizio Acampa, Alessandra Cartocci, Franco Laghi‐Pasini, Pier Leopoldo Capecchi, Mohamed Boutjdir, Deana Lazaro   +10 more
doaj   +1 more source

BKca and hEAG channels modulate proliferation and differentiation of human marrow-derived mesenchymal stem cells [PDF]

, 2012
INTRODUCTION: Bone marrow–derived mesenchymal stem cells (MSCs) are a promising cell source for regenerative medicine. However, cellular physiology is not fully understood in human MSCs.
Lau, CP, Li, GR, Tse, HF, Zhang, Y
core