Results 61 to 70 of about 25,547 (271)

Issues with Cefiderocol Testing: Comparing Commercial Methods to Broth Microdilution in Iron-Depleted Medium—Analyses of the Performances, ATU, and Trailing Effect According to EUCAST Initial and Revised Interpretation Criteria

Diagnostics
Background: The rise of multi-drug-resistant Gram-negative bacteria necessitates the development of new antimicrobial agents. Cefiderocol shows promising activity by exploiting bacterial iron transport systems to penetrate the outer membranes of ...
S. Stracquadanio, Alice Nicolosi, Andrea Marino, Maddalena Calvo, S. Stefani   +4 more
semanticscholar   +1 more source

Evaluation of the EUCAST Rapid Antimicrobial Susceptibility Test for Enterobacterales-Containing Blood Cultures in China

Journal of Clinical Microbiology, 2022
Bloodstream infection (BSI) is defined by the presence of microbes in the bloodstream and has high mortality. Early antimicrobial therapy is key to treating BSI patients.
Yuzhang Shan, Bijie Hu, Wei Guo, Beili Wang, Chunmei Zhou, S. Huang, Na Li   +6 more
semanticscholar   +1 more source

Interspecies Biofilm Dynamics Among Staphylococci: Inflammatory Contributions to Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Introduction Staphylococcus species are frequently isolated from the sinonasal niche of chronic rhinosinusitis (CRS) patients. While Staphylococcus aureus is often associated with recalcitrant CRS, Staphylococcus epidermidis and Staphylococcus lugdunensis are largely deemed commensal.
Sintayehu Ambachew, Mahnaz Ramezanpour, Clare M. Cooksley, Sholeh Feizi, Muhammed Awad, Kevin Aaron Fenix, Peter‐John Wormald, Alkis J. Psaltis, Sarah Vreugde   +8 more
wiley   +1 more source

Antimicrobial susceptibility testing of Mycobacterium tuberculosis complex isolates - The EUCAST broth microdilution reference method for MIC determination.

Clinical Microbiology and Infection, 2020
SCOPE Several methods are used worldwide for antibiotic susceptibility testing (AST) for the Mycobacterium tuberculosis complex (MTBC). The variability in the results obtained with these methods hampers to set epidemiological cut-off (ECOFF) values and ...
T. Schön, J. Werngren, D. Machado, E. Borroni, Maria Wijkander, G. Lina, J. Mouton, E. Matuschek, G. Kahlmeter, C. Giske, M. Santin, D. Cirillo, M. Viveiros, E. Cambau   +13 more
semanticscholar   +1 more source

Relationship between continuous infusion meropenem PK/PD target attainment and C‐reactive protein dynamics in onco‐haematologic patients with febrile neutropenia

British Journal of Clinical Pharmacology, EarlyView.
Aim Meropenem is a second‐line antimicrobial agent in the treatment of febrile neutropenia in onco‐haematological patients. A population pharmacokinetic/pharmacodynamic (PK/PD) analysis for assessing the relationship between meropenem exposure and C‐reactive protein (C‐RP) over time was conducted.
Chun Liu, Pier Giorgio Cojutti, J. G. Coen van Hasselt, Michele Bartoletti, Maddalena Giannella, Pierluigi Zinzani, Pierluigi Viale, Federico Pea   +7 more
wiley   +1 more source

Spectrophotometric reading of EUCAST antifungal susceptibility testing of Aspergillus fumigatus [PDF]

Clinical Microbiology and Infection, 2017
Given the increasing number of antifungal drugs and the emergence of resistant Aspergillus isolates, objective, automated and high-throughput antifungal susceptibility testing is important. The EUCAST E.Def 9.3 reference method for MIC determination of Aspergillus species relies on visual reading.
Meletiadis, J., Mortensen, K.L., Verweij, P.E., Mouton, J.W., Mouton, J.W., Arendrup, M.C.   +5 more
openaire   +6 more sources

Population-based inference of aminoglycoside resistance mechanisms in Escherichia coliResearch in context

EBioMedicine, 2019
Background: Interpretative reading of antimicrobial susceptibility test (AST) results allows inferring biochemical resistance mechanisms from resistance phenotypes.
Stefano Mancini, Martina Marchesi, Frank Imkamp, Karoline Wagner, Peter M. Keller, Chantal Quiblier, Elias Bodendoerfer, Patrice Courvalin, Erik C. Böttger   +8 more
doaj   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Corynebacterium diphtheriae and Corynebacterium ulcerans: development of EUCAST methods and generation of data on which to determine breakpoints.

Journal of Antimicrobial Chemotherapy
BACKGROUND Evidence-based clinical susceptibility breakpoints have been lacking for antimicrobial agents used for diphtheria. OBJECTIVES We aimed to evaluate broth microdilution and disc diffusion methods and create a dataset of MIC values and ...
A. Berger, Edgar Badell, J. Åhman, E. Matuschek, Nora Zidane, G. Kahlmeter, Andreas Sing, Sylvain Brisse   +7 more
semanticscholar   +1 more source

Antimicrobial Sensitivity Profile and Resistance Gene Research in Escherichia coli Isolated From Water and Fish From Lagoa da Conceição, Florianópolis, SC, Brazil

Food Safety and Health, EarlyView.
This paper highlights a concerning scenario of environmental contamination by multidrug‐resistant bacteria, underscoring the need for integrated surveillance and control strategies to address antimicrobial resistance in aquatic environments within the context of One Health.
Francisco Lucas de Amorim Nascimento, Luan Amaral Alexandre, Cynthia Farias Manassi, Alice Cristina da Silva, Luísa Aimée Schmitt Lobe, Gustavo Rocha, Mateus Rocha Ribas, Victor Wolleck, Gabriele Caroline Gottschalk de Abreu, Alessandra Valéria Vortmann, Sheila Mello da Silveira, Rodrigo Barcellos Hoff, Jussara Kasuko Palmeiro, Silvani Verruck   +13 more
wiley   +1 more source