Results 61 to 70 of about 11,020,597 (230)

RNA and DNA binding of inert oligonuclear ruthenium(II) complexes in live eukaryotic cells.

Dalton Transactions, 2015
Confocal microscopy was used to study the intracellular localisation of a series of inert polypyridylruthenium(II) complexes with three eukaryotic cells lines - baby hamster kidney (BHK), human embryonic kidney (HEK-293) and liver carcinoma (Hep-G2).
X. Li, A. K. Gorle, T. Ainsworth, K. Heimann, C. Woodward, J. Collins, F. Keene   +6 more
semanticscholar   +1 more source

How does the chromatin fiber deal with topological constraints?

, 2004
In the nuclei of eukaryotic cells, DNA is packaged through several levels of compaction in an orderly retrievable way that enables the correct regulation of gene expression. The functional dynamics of this assembly involves the unwinding of the so-called
A. Prunell, J. Bednar, Jean-Marc Victor, Julien Mozziconacci, M. G. Poirier, Maria Barbi, W. Keller   +6 more
core   +2 more sources

Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia [PDF]

, 2013
BACKGROUND: Chemotherapy-induced hair loss (alopecia) (CIA) is one of the most feared side effects of chemotherapy among cancer patients. There is currently no pharmacological approach to minimize CIA, although one strategy that has been proposed ...
Chu, Jennifer, Deslongchamps, Pierre, Dow, Lukas E., Lowe, Scott W., Nasr, Zeina, Paquet, Marilene, Pelletier, Jerry, Porco, John A., Ravindar, Kontham, Somaiah, Ragam   +9 more
core   +2 more sources

An Autocrine Proliferation Repressor Regulates Dictyostelium discoideum Proliferation and Chemorepulsion Using the G Protein-Coupled Receptor GrlH

mBio, 2018
In eukaryotic microbes, little is known about signals that inhibit the proliferation of the cells that secrete the signal, and little is known about signals (chemorepellents) that cause cells to move away from the source of the signal.
Yu Tang, Yuantai Wu, Sarah E. Herlihy, Francisco J. Brito-Aleman, Jose H. Ting, Chris Janetopoulos, Richard H. Gomer   +6 more
doaj   +1 more source

Functional expression of the eukaryotic proton pump rhodopsin OmR2 in Escherichia coli and its photochemical characterization

Scientific Reports, 2021
Microbial rhodopsins are photoswitchable seven-transmembrane proteins that are widely distributed in three domains of life, archaea, bacteria and eukarya.
Masuzu Kikuchi, Keiichi Kojima, Shin Nakao, Susumu Yoshizawa, Shiho Kawanishi, Atsushi Shibukawa, Takashi Kikukawa, Yuki Sudo   +7 more
doaj   +1 more source

Protein-responsive ribozyme switches in eukaryotic cells

Nucleic Acids Research, 2014
Genetic devices that directly detect and respond to intracellular concentrations of proteins are important synthetic biology tools, supporting the design of biological systems that target, respond to or alter specific cellular states.
A. B. Kennedy, James V. Vowles, Leo d’Espaux, C. Smolke   +3 more
semanticscholar   +1 more source

Phosphorylation stoichiometries of human eukaryotic initiation factors. [PDF]

, 2014
Eukaryotic translation initiation factors are the principal molecular effectors regulating the process converting nucleic acid to functional protein. Commonly referred to as eIFs (eukaryotic initiation factors), this suite of proteins is comprised of at ...
Andaya, Armann, Fraser, Christopher S, Jia, Weitao, Leary, Julie A, Villa, Nancy   +4 more
core   +2 more sources

A small molecule inhibitor of leucine carboxyl methyltransferase-1 inhibits cancer cell survival

Frontiers in Drug Discovery
Reversible phosphorylation is the basis for signal transduction in eukaryotic cells, and this is tightly controlled by the complex interplay of kinases and phosphatases.
O. A. Arosarena, O. A. Arosarena, O. A. Arosarena, A. S. Saribas, E. P. Papadopoulos   +4 more
doaj   +1 more source

Transfer of DNA from Bacteria to Eukaryotes

mBio, 2016
Historically, the members of the Agrobacterium genus have been considered the only bacterial species naturally able to transfer and integrate DNA into the genomes of their eukaryotic hosts.
Benoît Lacroix, Vitaly Citovsky
doaj   +1 more source

Non-coding RNA regulation in pathogenic bacteria located inside eukaryotic cells

Frontiers in Cellular and Infection Microbiology, 2014
Intracellular bacterial pathogens have evolved distinct lifestyles inside eukaryotic cells. Some pathogens coexist with the infected cell in an obligate intracellular state, whereas others transit between the extracellular and intracellular environment ...
A. D. Ortega, J. Quereda, M. Pucciarelli, F. G. Portillo, Centro García-del Portillo   +4 more
semanticscholar   +1 more source