Dual expression recombinase based (DERB) single vector system for high throughput screening and verification of protein interactions in living cells [PDF]
, 2008 Identification of novel protein interactions and their mediators is fundamental in understanding cellular processes and is necessary for protein-targeted therapy.
Jehonathan Pinthus +2 more
core +2 more sources
The molecular chaperone Hsp90 is a component of the cap-binding complex and interacts with the translational repressor Cup during Drosophila oogenesis [PDF]
, 2009 In metazoa, the spatio-temporal translation of diverse mRNAs is essential to guarantee proper oocyte maturation and early embryogenesis. The eukaryotic translation initiation factor 4E (eIF4E), which binds the 5′ cap structure of eukaryotic mRNAs ...
COZZOLINO M. +10 more
core +1 more source
Nature Communications, 2017 Eukaryotic organisms are continuously exposed to bacteriophages, which are efficient gene transfer agents in bacteria. However, bacteriophages are considered not to pass the eukaryotic cell membrane and enter nonphagocytic cells.
Timo A. Lehti +3 more
semanticscholar +1 more source
Telomeres in Evolution and Development from Biosemiotic Perspective [PDF]
, 2007 Telomeres identify natural chromosome ends being different from broken DNA through differences in their "molecular syntax" (M.Eigen) which determines the functions of reverse transcriptase and its integrated RNA template, telomerase.
Guenther Witzany
core +3 more sources
Selection of resistance to cisplatin in saccharomyces cerevisiae as a model for antineoplastic drugs studies [PDF]
, 2019 The budding yeast (S. cerevisiae) is an excellent eukaryotic model to study the antineoplastic drugs effects, due to the well-characterized metabolic and genetic characteristics and the conserved similarity in molecular mechanisms with other species ...
Burgos-Molina, Antonio Manuel +3 more
core
Making ends meet: repairing breaks in bacterial DNA by non-homologous end-joining. [PDF]
, 2006 DNA double-strand breaks (DSBs) are one of the most dangerous forms of DNA lesion that can result in genomic instability and cell death. Therefore cells have developed elaborate DSB-repair pathways to maintain the integrity of genomic DNA.
Bowater, Richard, Doherty, Aidan J
core +5 more sources
Scanning X-Ray Nanodiffraction on Living Eukaryotic Cells in Microfluidic Environments
, 2014 High-resolution x-ray imaging techniques offer a variety of possibilities for studying the nanoscale structure of biological cells. A challenging task remains the study of cells by x rays in their natural, aqueous environment.
B. Weinhausen +7 more
semanticscholar +1 more source
A systematic approach to cancer: evolution beyond selection. [PDF]
, 2017 Cancer is typically scrutinized as a pathological process characterized by chromosomal aberrations and clonal expansion subject to stochastic Darwinian selection within adaptive cellular ecosystems.
Miller, William B, Torday, John S
core +1 more source
Unraveling Adaptation in Eukaryotic Pathways: Lessons from Protocells [PDF]
, 2013 Eukaryotic adaptation pathways operate within wide-ranging environmental conditions without stimulus saturation. Despite numerous differences in the adaptation mechanisms employed by bacteria and eukaryotes, all require energy consumption.
De Palo, Giovanna, Endres, Robert G.
core +4 more sources
Transcription factor clusters regulate genes in eukaryotic cells
eLife, 2017 Transcription is regulated through binding factors to gene promoters to activate or repress expression, however, the mechanisms by which factors find targets remain unclear.
Adam JM Wollman +5 more
doaj +1 more source