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Structural Insights into Eukaryotic DNA Replication [PDF]
Frontiers in Microbiology, 2014 Three DNA polymerases of the B family function at the replication fork in eukaryotic cells: DNA polymerases α, δ, and ε. DNA polymerase α, an heterotetramer composed of two primase subunits and two polymerase subunits, initiates replication.
Sylvie eDoublié, Karl E Zahn
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Ancient diversification of eukaryotic MCM DNA replication proteins [PDF]
BMC Evolutionary Biology, 2009 Background Yeast and animal cells require six mini-chromosome maintenance proteins (Mcm2-7) for pre-replication complex formation, DNA replication initiation and DNA synthesis. These six individual MCM proteins form distinct heterogeneous subunits within
Aves Stephen J +2 more
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Emerging players in the initiation of eukaryotic DNA replication [PDF]
Cell Division, 2012 Faithful duplication of the genome in eukaryotes requires ordered assembly of a multi-protein complex called the pre-replicative complex (pre-RC) prior to S phase; transition to the pre-initiation complex (pre-IC) at the beginning of DNA replication ...
Shen Zhen, Prasanth Supriya G
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PLoS Genetics, 2011 Coordinated replication of eukaryotic genomes is intrinsically asymmetric, with continuous leading strand synthesis preceding discontinuous lagging strand synthesis.
Izumi Miyabe +2 more
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Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading. [PDF]
Science, 2017 Coster G, Diffley JFX.
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Sld3-MCM Interaction Facilitated by Dbf4-Dependent Kinase Defines an Essential Step in Eukaryotic DNA Replication Initiation. [PDF]
Front Microbiol, 2016 Fang D, Cao Q, Lou H.
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Four decades of Eukaryotic DNA replication: From yeast genetics to high-resolution cryo-EM structures of the replisome. [PDF]
Proc Natl Acad Sci U S ATye BK.
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The Many Roles of PCNA in Eukaryotic DNA Replication. [PDF]
Enzymes, 2016 Boehm EM, Gildenberg MS, Washington MT.
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Nucleosome-directed replication origin licensing independent of a consensus DNA sequence
Nature Communications, 2022 Most eukaryotes do not use a consensus DNA sequence as binding sites for the origin recognition complex (ORC) to initiate DNA replication, however budding yeast do. Here the authors show S. cerevisiae ORC can bind nucleosomes near nucleosome-free regions
Sai Li +5 more
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Research, 2022 DNA replication initiation is a complex process involving various genetic and epigenomic signatures. The correct identification of replication origins (ORIs) could provide important clues for the study of a variety of diseases caused by replication. Here,
Fu-Ying Dao +3 more
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