Results 91 to 100 of about 206,173 (282)

Template-directed biopolymerization: tape-copying Turing machines

, 2012
DNA, RNA and proteins are among the most important macromolecules in a living cell. These molecules are polymerized by molecular machines. These natural nano-machines polymerize such macromolecules, adding one monomer at a time, using another linear ...
Chowdhury, Debashish, Sharma, Ajeet K.
core   +1 more source

Structure and Function of a Mycobacterial NHEJ DNA Repair Polymerase [PDF]

, 2006
Non homologous end-joining (NHEJ)-mediated repair of DNA double-strand breaks in prokaryotes requires Ku and a specific multidomain DNA ligase (LigD).
Aidan J. Doherty, Angel J. Picher, Arezi, Augustin, Bowater, Chen, Chen, Critchlow, Daley, Darren Thompson, DeFazio, Della, Dominguez, Emsley, Garcia-Diaz, Gavin C. Fox, Gong, Gong, Ito, Iyer, Jones, Krejci, La Fortelle, Lao-Sirieix, Lao-Sirieix, Lipps, Luis Blanco, Ma, Ma, Mahajan, Matsumoto, McCoy, Murshudov, Nick McElhinney, Nick McElhinny, Nick McElhinny, Nigel C. Brissett, Paula Andrade, Paull, Picher, Pitcher, Pitcher, Potterton, Potterton, Powell, Prasad, Ramsden, Raquel Juarez, Robert S. Pitcher, Ruiz, Rydberg, Singhal, Steitz, Tseng, Weller, Wilson, Winn, Wu, Zhang, Zhu   +59 more
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

A latent ability to persist: differentiation in Toxoplasma gondii [PDF]

, 2018
A critical factor in the transmission and pathogenesis of Toxoplasma gondii is the ability to convert from an acute disease-causing, proliferative stage (tachyzoite), to a chronic, dormant stage (bradyzoite).
Jeffers, Victoria, Kim, Kami, Sullivan, William J., Jr., Tampaki, Zoi   +3 more
core   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Replication Stress and Consequential Instability of the Genome and Epigenome

Molecules, 2019
Cells must faithfully duplicate their DNA in the genome to pass their genetic information to the daughter cells. To maintain genomic stability and integrity, double-strand DNA has to be replicated in a strictly regulated manner, ensuring the accuracy of ...
Pawlos S. Tsegay, Yanhao Lai, Yuan Liu
doaj   +1 more source

Evolutionary rates and gene dispensability associate with replication timing in the Archaeon Sulfolobus islandicus [PDF]

, 2010
In bacterial chromosomes, the position of a gene relative to the single origin of replication generally reflects its replication timing, how often it is expressed, and consequently, its rate of evolution.
Cooper, Vaughn S., Flynn, Kenneth M., Hatcher, Philip J., Vohr, Samuel H.   +3 more
core   +2 more sources

CRISPRa Lipid Nanocomplex‐Mediated Mt3 Targeting Enhances Astrocytic Endocytosis of Amyloid‐β in an Alzheimer's Disease Mouse Model

Advanced Science, EarlyView.
GeTe exhibits intrinsically high carrier concentrations that limit its thermoelectric performance. Herein, CuAgSe alloying synergistically tunes the band structure, induces band flattening and valence‐band convergence, promotes Cu‐ion delocalization, and generates multiscale hierarchical structures to suppress phonon transport.
Junhang Park, Boyoung Kim, Minki Ha, Moonsu Park, Hongji Ryu, Hyerin Yu, Sungsoo Park, Yoon‐Seok Roh, Key‐Hwan Lim, Jin Tae Hong, Sang‐Bae Han, Chun‐Woong Park, Seok‐Beom Yong, Hanseul Park   +13 more
wiley   +1 more source

Monitoring and quantifying replication fork dynamics with high-throughput methods

Communications Biology
Before each cell division, eukaryotic cells must replicate their chromosomes to ensure the accurate transmission of genetic information. Chromosome replication involves more than just DNA duplication; it also includes chromatin assembly, inheritance of ...
Nora Fajri, Nataliya Petryk
doaj   +1 more source

Two subunits of human ORC are dispensable for DNA replication and proliferation

eLife, 2016
The six-subunit Origin Recognition Complex (ORC) is believed to be an essential eukaryotic ATPase that binds to origins of replication as a ring-shaped heterohexamer to load MCM2-7 and initiate DNA replication. We have discovered that human cell lines in
Etsuko Shibata, Manjari Kiran, Yoshiyuki Shibata, Samarendra Singh, Shashi Kiran, Anindya Dutta   +5 more
doaj   +1 more source