Results 11 to 20 of about 206,173 (282)
Cell Reports, 2020 Summary: Eukaryotic DNA replication licensing is a prerequisite for, and plays a role in, regulating genome duplication that occurs exactly once per cell cycle.
Aftab Amin +10 more
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Coupling DNA Replication and Spindle Function in Saccharomyces cerevisiae
Cells, 2021 In the yeast Saccharomyces cerevisiae DNA replication and spindle assembly can overlap. Therefore, signaling mechanisms modulate spindle dynamics in order to ensure correct timing of chromosome segregation relative to genome duplication, especially when ...
Dimitris Liakopoulos
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Proficient replication of the yeast genome by a viral DNA polymerase [PDF]
, 2016 DNA replication in eukaryotic cells requires minimally three B-family DNA polymerases: Pol α, Pol δ, and Pol ϵ. Pol δ replicates and matures Okazaki fragments on the lagging strand of the replication fork.
Burgers, Peter M +2 more
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Affinity Purification of an Archaeal DNA Replication Protein Network
mBio, 2010 Nineteen Thermococcus kodakarensis strains have been constructed, each of which synthesizes a different His6-tagged protein known or predicted to be a component of the archaeal DNA replication machinery.
Zhuo Li +4 more
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Role for RNA: DNA hybrids in origin-independent replication priming in a eukaryotic system [PDF]
, 2015 DNA replication initiates at defined replication origins along eukaryotic chromosomes, ensuring complete genome duplication within a single S-phase. A key feature of replication origins is their ability to control the onset of DNA synthesis mediated by ...
Aguilera López, Andrés +3 more
core +1 more source
Helicase Loading at Chromosomal Origins of Replication [PDF]
, 2013 Loading of the replicative DNA helicase at origins of replication is of central importance in DNA replication. As the first of the replication fork proteins assemble at chromosomal origins of replication, the loaded helicase is required for the ...
Bell, Stephen P., Kaguni, Jon M.
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Replicating Damaged DNA in Eukaryotes [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 DNA damage is one of many possible perturbations that challenge the mechanisms that preserve genetic stability during the copying of the eukaryotic genome in S phase. This short review provides, in the first part, a general introduction to the topic and an overview of checkpoint responses.
Nimrat, Chatterjee, Wolfram, Siede
openaire +2 more sources
Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion [PDF]
, 2019 Genome stability involves accurate replication and DNA repair. Broken replication forks, such as those encountering a nick, lead to double strand breaks (DSBs), which are preferentially repaired by sister-chromatid recombination (SCR).
Aguilera López, Andrés +2 more
core +1 more source
Cell Reports, 2019 Summary: Progression of DNA replication depends on the ability of the replisome complex to overcome nucleoprotein barriers. During eukaryotic replication, the CMG helicase translocates along the leading-strand template and unwinds the DNA double helix ...
Hazal B. Kose +3 more
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Quantification of DNA-associated proteins inside eukaryotic cells using single-molecule localization microscopy [PDF]
, 2014 Development of single-molecule localization microscopy techniques has allowed nanometre scale localization accuracy inside cells, permitting the resolution of ultra-fine cell structure and the elucidation of crucial molecular mechanisms.
Adam T. Watson +46 more
core +1 more source