Results 21 to 30 of about 106,156 (238)
DNA Copy-Number Control through Inhibition of Replication Fork Progression
Cell Reports, 2014 Proper control of DNA replication is essential to ensure faithful transmission of genetic material and prevent chromosomal aberrations that can drive cancer progression and developmental disorders.
Jared T. Nordman +7 more
doaj +1 more source
BMC Genetics, 2007 Background Information transfer systems in Archaea, including many components of the DNA replication machinery, are similar to those found in eukaryotes.
DasSarma Shiladitya +2 more
doaj +1 more source
Transcriptionally Driven DNA Replication Program of the Human Parasite Leishmania major
Cell Reports, 2016 Faithful inheritance of eukaryotic genomes requires the orchestrated activation of multiple DNA replication origins (ORIs). Although origin firing is mechanistically conserved, how origins are specified and selected for activation varies across different
Rodrigo Lombraña +8 more
doaj +1 more source
DNA Sliding Clamps as Therapeutic Targets
Frontiers in Molecular Biosciences, 2018 Chromosomal DNA replication is achieved by an assembly of multi-protein complexes at the replication fork. DNA sliding clamps play an important role in this assembly and are essential for cell viability. Inhibitors of bacterial (β-clamp) and eukaryal DNA
Amanda S. Altieri +2 more
doaj +1 more source
Diversity of eukaryotic DNA replication origins revealed by genome-wide analysis of chromatin structure. [PDF]
PLoS Genetics, 2010 Eukaryotic DNA replication origins differ both in their efficiency and in the characteristic time during S phase when they become active. The biological basis for these differences remains unknown, but they could be a consequence of chromatin structure ...
Nicolas M Berbenetz +2 more
doaj +1 more source
Control of DNA Replication Initiation by Ubiquitin
Cells, 2018 Eukaryotic cells divide by accomplishing a program of events in which the replication of the genome is a fundamental part. To ensure all cells have an accurate copy of the genome, DNA replication occurs only once per cell cycle and is controlled by ...
Esperanza Hernández-Carralero +5 more
doaj +1 more source
Characterisation of unessential genes required for survival under conditions of DNA stress
Journal of Genetic Engineering and Biotechnology, 2020 Background Genomic instability is a hallmark of cancer. Cancer progression depends on the development and amplification of mutations that alter the cellular response to threats to the genome. This can lead to DNA replication stress and the potential loss
Hassan Ahmed Ezzat, Clive Price
doaj +1 more source
Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells
FEBS Letters, EarlyView.Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan +2 more
wiley +1 more source
Evolution of DNA replication protein complexes in eukaryotes and Archaea. [PDF]
PLoS ONE, 2010 BACKGROUND: The replication of DNA in Archaea and eukaryotes requires several ancillary complexes, including proliferating cell nuclear antigen (PCNA), replication factor C (RFC), and the minichromosome maintenance (MCM) complex.
Nicholas Chia, Isaac Cann, Gary J Olsen
doaj +1 more source
FEBS Letters, EarlyView.Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley +1 more source