Results 81 to 90 of about 106,156 (238)

Sanggenol L Enhances Temozolomide Drug Sensitivity by Inhibiting Mitophagy and Inducing Apoptosis Through the Regulation of the TRIM16‐OPTN Axis in Glioblastoma

Advanced Science, EarlyView.
Sanggenol L, a flavonoid from mulberry, enhances glioblastoma sensitivity to temozolomide by inhibiting mitophagy and inducing apoptosis through TRIM16‐mediated OPTN degradation. In animal studies, liposomal delivery of Sanggenol L significantly improves the efficacy of its combination with TMZ, providing new insights into glioblastoma treatment ...
Hongbo Chang, Jianbing Hou, Xin Hu, Nana Hou, Minghao Xu, Yi Du, Jingyang Xu, Yongzhao Wang, Zhuohao Xie, Junbo Shi, Yundong Zhang, Hongjuan Cui   +11 more
wiley   +1 more source

Roles for DNA polymerase δ in initiating and terminating leading strand DNA replication

Nature Communications, 2019
DNA polymerases epsilon and delta, respectively, perform the majority of leading and lagging strand replication of the eukaryotic nuclear genome. Here the authors map the ribonucleotide fingerprints of the polymerases to show the special roles of ...
Zhi-Xiong Zhou, Scott A. Lujan, Adam B. Burkholder, Marta A. Garbacz, Thomas A. Kunkel   +4 more
doaj   +1 more source

Initiation of bacteriophage T4 DNA replication and replication fork dynamics: a review in the Virology Journal series on bacteriophage T4 and its relatives

Virology Journal, 2010
Bacteriophage T4 initiates DNA replication from specialized structures that form in its genome. Immediately after infection, RNA-DNA hybrids (R-loops) occur on (at least some) replication origins, with the annealed RNA serving as a primer for leading ...
Brister J Rodney, Kreuzer Kenneth N
doaj   +1 more source

Deciphering DNA replication dynamics in eukaryotic cell populations in relation with their averaged chromatin conformations [PDF]

, 2016
Arach Goldar, A. Arnéodo, Benjamin Audit, Françoise Argoul, Aurélien Rappailles, Guillaume Guilbaud, Nataliya Petryk, Malik Kahli, Olivier Hyrien   +8 more
openalex   +1 more source

Arabidopsis TRB Proteins Form Two Closely Related Complexes to Mediate H3K4me3 Demethylation and Transcriptional Repression

Advanced Science, EarlyView.
This study reveals that Arabidopsis telomere repeat binding proteins (TRBs) form two closely related complexes. These complexes mediate H3K4me3 demethylation and transcriptional repression through a positive feedback loop and cooperate with PEAT and PRC2 complexes to regulate multiple histone modifications and gene expression across the genome ...
Qi Wang, Dan‐Yang Yuan, Yu‐Jia Lu, Xin Wang, Hao Zheng, Lin Li, She Chen, Xin‐Jian He   +7 more
wiley   +1 more source

Structural and Functional Versatility of the Amyloidogenic Non‐Amidated Variant of the Antimicrobial Peptide Citropin 1.3

Advanced Science, EarlyView.
Citropin 1.3 is an antimicrobial peptide derived from amphibians that forms amyloid structures. Here, the structural and functional properties of citropin 1.3 are characterized. Using high‐resolution imaging approaches, a variety of canonical and undescribed fibril morphologies are identified.
Fabio Strati, Mariana Pigozzi Cali, Yehudi Bloch, Siavash Mostafavi, Jim Monistrol, Aleksandr Golubev, Bader Rayan, Emil Gustavsson, Meytal Landau   +8 more
wiley   +1 more source

R-loops acted on by RNase H1 influence DNA replication timing and genome stability in Leishmania

Nature Communications
Genomes in eukaryotes normally undergo DNA replication in a choreographed temporal order, resulting in early and late replicating chromosome compartments. Leishmania, a human protozoan parasite, displays an unconventional DNA replication program in which
Jeziel D. Damasceno, Emma M. Briggs, Marija Krasilnikova, Catarina A. Marques, Craig Lapsley, Richard McCulloch   +5 more
doaj   +1 more source

Regulation of DNA Replication through Natural  Impediments in the Eukaryotic Genome [PDF]

, 2017
Mariana C. Gadaleta, Eishi Noguchi
openalex   +1 more source

Snord15b Maintains Stemness of Intestinal Stem Cells via Enhancement of Alternative Splicing of Btrc Short Isoform for Suppression of β‐Catenin Ubiquitination

Advanced Science, EarlyView.
In intestinal stem cells (ISCs), Snord15b associates with Ilf2 to recruit splicing factors for alternative splicing of Btrc mRNA, leading to the generation of short Btrc. This short Btrc fails to form a functional E3 ubiquitin ligase complex for β‐catenin ubiquitination and degradation.
Yuwei Xu, Peikang Zhang, Zhen Xiong, Yufei Lan, Hui Guo, Runyuan Wu, Cunzhen Li, Hongzhe Fan, Ying Du, Xiaoxiao Zhu, Dongdong Fan, Zhonglong Wang, Yong Tian, Zusen Fan   +13 more
wiley   +1 more source

Mcm10 Plays a Role in Functioning of the Eukaryotic Replicative DNA Helicase, Cdc45-Mcm-GINS [PDF]

, 2012
George J. Watase, Haruhiko Takisawa, Masato T. Kanemaki   +2 more
openalex   +1 more source