Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism. [PDF]
Adv Nutr, 2012 Regulation of mRNA translation is a rapid and effective means to couple changes in the cellular environment with global rates of protein synthesis. In response to stresses, such as nutrient deprivation and accumulation of misfolded proteins in the endoplasmic reticulum, phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α~P ...
Baird TD, Wek RC.
europepmc +5 more sources
Stepwise assembly of the eukaryotic translation initiation factor 2 complex [PDF]
Journal of Biological Chemistry, 2022 The eukaryotic translation initiation factor 2 (eIF2) has key functions in the initiation step of protein synthesis. eIF2 guides the initiator tRNA to the ribosome, participates in scanning of the mRNA molecule, supports selection of the start codon, and modulates the translation of mRNAs in response to stress.
Vanselow, Sven +3 more
openaire +4 more sources
Effects of Essential Amino Acid Deficiency on General Control Nonderepressible 2/Eukaryotic Initiation Factor 2 Signaling and Proteomic Changes in Primary Bovine Mammary Epithelial Cells [PDF]
Current Issues in Molecular Biology, 2022 We hypothesized that the general control nonderepressible 2 (GCN2)/eukaryotic initiation factor 2 (eIF2) signaling pathway and intracellular protein synthesis (PS) are regulated to maintain milk PS in primary bovine mammary epithelial cells (MECs) under ...
Zulma Tatiana Ruiz-Cortés +2 more
doaj +2 more sources
Am J Physiol Endocrinol Metab, 2013 Asparaginase is an important drug in the treatment regimen for acute lymphoblastic leukemia. Asparaginase depletes circulating asparagine and glutamine, activating an amino acid stress response (AAR) involving phosphorylation of eukaryotic initiation factor 2 (eIF2) by general control nonderepressible kinase 2 (GCN2).
Wilson GJ +4 more
europepmc +5 more sources
Eukaryotic initiation factor 2 signaling behind neural invasion linked with lymphatic and vascular invasion in pancreatic cancer [PDF]
Scientific Reports, 2021 Perineural invasion (PNI) is a typical poor prognostic factor in pancreatic ductal adenocarcinoma (PDAC). The mechanisms linking PNI to poor prognosis remain unclear. This study aimed to clarify what changes occurred alongside PNI in PDAC.
Taiichi Wakiya +11 more
doaj +2 more sources
Monocyte eukaryotic initiation factor 2 signaling differentiates 17-hydroxy-docosahexaenoic acid levels and pain [PDF]
iScienceSummary: Our goal was to probe the potential transcriptomic basis for the relationship between plasma levels of the specialized pro-resolving precursor, 17-hydroxy-docosahexaenoic acid (17-HDHA) and chronic pain. Participants with osteoarthritis (average
Peter R.W. Gowler +12 more
doaj +2 more sources
Nitric oxide: a regulator of eukaryotic initiation factor 2 kinases. [PDF]
Free Radic Biol Med, 2011 Generation of nitric oxide (NO(•)) can upstream induce and downstream mediate the kinases that phosphorylate the α subunit of eukaryotic initiation factor 2 (eIF2α), which plays a critical role in regulating gene expression. There are four known eIF2α kinases (EIF2AKs), and NO(•) affects each one uniquely. Whereas NO(•) directly activates EIF2AK1 (HRI),
Tong L, Heim RA, Wu S.
europepmc +4 more sources
Epigallocatechin Gallate Ameliorates Granulosa Cell Developmental via the Eukaryotic Initiation Factor 2 Alpha/Activating Transcription Factor 4 Pathway in Hyperthyroid Female Rats [PDF]
AntioxidantsFollicular development is recognized as a highly complex biological process regulated by multiple factors. Thyroid hormone (TH) is considered one of the key regulators of female reproduction, and its dysregulation can significantly impair follicular ...
Ying Sun +6 more
doaj +2 more sources
Molecular evolution and functional divergence of eukaryotic translation initiation factor 2-alpha kinases. [PDF]
PLoS ONE, 2018 Eukaryotic translation initiation factor 2-alpha kinase (EIF2AK) proteins inhibit protein synthesis at translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock, and heat shock ...
K Hari Krishna, Muthuvel Suresh Kumar
doaj +4 more sources
Gefitinib and Erlotinib Lead to Phosphorylation of Eukaryotic Initiation Factor 2 Alpha Independent of Epidermal Growth Factor Receptor in A549 Cells. [PDF]
PLoS ONE, 2015 Gefitinib and erlotinib are anticancer agents, which inhibit epidermal growth factor receptor (EGFR) tyrosine kinase. Interstitial lung disease (ILD) occurs in patients with non-small cell lung cancer receiving EGFR inhibitors.
Satoshi Koyama +7 more
doaj +2 more sources