Proceedings of the National Academy of Sciences, 1998 As the amount of available sequence data increases, it becomes apparent that our understanding of translation initiation is far from comprehensive and that prior conclusions concerning the origin of the process are wrong. Contrary to earlier conclusions, key elements of translation initiation originated at the Universal Ancestor stage, for homologous ...
N C, Kyrpides, C R, Woese
openaire +4 more sources
Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice. [PDF]
J Nutr, 2017 Pettit AP +11 more
europepmc +2 more sources
Eukaryotic initiation factor 2 (eIF2) signaling regulates proinflammatory cytokine expression and bacterial invasion. [PDF]
J Biol Chem, 2012 In eukaryotic cells, there are two well characterized pathways that regulate translation initiation in response to stress, and each have been shown to be targeted by various viruses. We recently showed in a yeast-based model that the bacterial virulence factor YopJ disrupts one of these pathways, which is centered on the α-subunit of the translation ...
Shrestha N +5 more
europepmc +4 more sources
Translational control by messenger RNA competition for eukaryotic initiation factor 2.
Journal of Biological Chemistry, 1982 Translation of globin mRNA in a micrococcal nuclease-treated reticulocyte lysate was studied in the presence of increasing amounts of Mengovirus RNA, under conditions in which the number of translation initiation events remains constant as judged by the transfer of label from N-formyl[35S]methionyl-tRNAf into protein.
H, Rosen, G, Di Segni, R, Kaempfer
openaire +3 more sources
Ribosome-binding Domain of Eukaryotic Initiation Factor-2 Kinase GCN2 Facilitates Translation Control [PDF]
Journal of Biological Chemistry, 1998 A family of protein kinases regulate translation initiation in response to cellular stresses by phosphorylation of eukaryotic initiation factor-2 (eIF-2). One family member from yeast, GCN2, contains a region homologous to histidyl-tRNA synthetases juxtaposed to the kinase catalytic domain.
S, Zhu, R C, Wek
openaire +3 more sources
Inhibition of Eukaryotic Initiation Factor 2 Alpha Phosphatase Reduces Tissue Damage and Improves Learning and Memory after Experimental Traumatic Brain Injury. [PDF]
J Neurotrauma, 2015 Dash PK +7 more
europepmc +2 more sources
Roles of the integrated stress response in regulation of inflammatory reactions [PDF]
Frontiers in ImmunologyThe integrated stress response (ISR) is a conserved cyto-protective mechanism, which has fundamental roles in maintaining cell viability under various conditions when intracellular and/or extracellular homeostasis is disrupted.
Fan Jiang +10 more
doaj +2 more sources
SUMO-2 promotes mRNA translation by enhancing interaction between eIF4E and eIF4G. [PDF]
PLoS ONE, 2014 Small ubiquitin-like modifier (SUMO) proteins regulate many important eukaryotic cellular processes through reversible covalent conjugation to target proteins.
Li-zhao Chen +12 more
doaj +1 more source
Eukaryotic protein synthesis initiation factor 2 [PDF]
European Journal of Biochemistry, 1991 Polyproanthocyanidin (PPA), a phenolic polymer isolated from the plant Alhagi kirgisorum S. was found to interact strongly with eukaryotic initiation factor 2 (eIF‐2), thereby inhibiting reactions involving this protein. When added to a rabbit reticulocyte lysate system, PPA blocks in vitro translation and it appears to selectively bind and precipitate
W, Kudlicki +7 more
openaire +2 more sources
Aquaculture Reports, 2022 A 90-day feeding trial was conducted to evaluate the effects of cottonseed protein concentrate (CPC) replacing dietary fishmeal on growth performance, feed utilization and protein metabolism of large yellow croaker (initial body weight: 191.60 ± 1.36 g).
Shuangjie Tian +7 more
doaj +1 more source