Results 21 to 30 of about 173,490 (195)

Mechanisms of action of cytoplasmic microRNAs. Part 5. MicroRNA-mediated silencing caused during translation initiation and post-initiation

Zdorovʹe Rebenka, 2022
The scientific review considers the mechanisms of action of cytoplasmic microRNAs, namely miRNA-mediated silencing, which is caused during the initiation and post-initiation period of translation.
A.E. Abaturov, V.L. Babуch
doaj   +1 more source

Activating Transcription Factor 3 Is Integral to the Eukaryotic Initiation Factor 2 Kinase Stress Response

Molecular and Cellular Biology, 2004
In response to environmental stress, cells induce a program of gene expression designed to remedy cellular damage or, alternatively, induce apoptosis.
Hao Jiang, S. A. Wek, Barbara C Mcgrath, D. Lu, Tsonwin Hai, H. Harding, Xiaozhong Wang, D. Ron, D. Cavener, R. Wek   +9 more
semanticscholar   +1 more source

4EBP-Dependent Signaling Supports West Nile Virus Growth and Protein Expression

Viruses, 2016
West Nile virus (WNV) is a (+) sense, single-stranded RNA virus in the Flavivirus genus. WNV RNA possesses an m7GpppNm 5′ cap with 2′-O-methylation that mimics host mRNAs preventing innate immune detection and allowing the virus to translate its RNA ...
Katherine D. Shives, Aaron R. Massey, Nicholas A. May, Thomas E. Morrison, J. David Beckham   +4 more
doaj   +1 more source

Investigations on the mode of action of gephyronic acid, an inhibitor of eukaryotic protein translation from myxobacteria. [PDF]

PLoS ONE, 2018
The identification of inhibitors of eukaryotic protein biosynthesis, which are targeting single translation factors, is highly demanded. Here we report on a small molecule inhibitor, gephyronic acid, isolated from the myxobacterium Archangium gephyra ...
Yazh Muthukumar, Johanna Münkemer, Daniel Mathieu, Christian Richter, Harald Schwalbe, Heinrich Steinmetz, Wolfgang Kessler, Joachim Reichelt, Ulrike Beutling, Ronald Frank, Konrad Büssow, Joop van den Heuvel, Mark Brönstrup, Richard E Taylor, Sabine Laschat, Florenz Sasse   +15 more
doaj   +1 more source

EIF2AK2 (eukaryotic translation initiation factor 2-alpha kinase 2) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on EIF2AK2 (eukaryotic translation initiation factor 2-alpha kinase 2), with data on DNA, on the protein encoded, and where the gene is implicated.
Blalock, WL, Cocco, L
openaire   +2 more sources

Minimum Requirements for the Function of Eukaryotic Translation Initiation Factor 2 [PDF]

Genetics, 2001
Abstract Eukaryotic translation initiation factor 2 (eIF2) is a G protein heterotrimer required for GTP-dependent delivery of initiator tRNA to the ribosome. eIF2B, the nucleotide exchange factor for eIF2, is a heteropentamer that, in yeast, is encoded by four essential genes and one nonessential gene.
F L, Erickson, J, Nika, S, Rippel, E M, Hannig   +3 more
openaire   +2 more sources

Isolation of Flavonoids from Deguelia duckeana and Their Effect on Cellular Viability, AMPK, eEF2, eIF2 and eIF4E

Molecules, 2016
Preparations of Deguelia duckeana, known in Brazil as timbó, are used by indigenous people to kill fish. Reinvestigation of its extracts resulted in the isolation and identification of 11 known flavonoids identified as 3,5,4’-trimethoxy-4-prenylstilbene (
Lorena M. C. Cursino, Nerilson M. Lima, Renato Murillo, Cecilia V. Nunez, Irmgard Merfort, Matjaz Humar   +5 more
doaj   +1 more source

Dimerization and Release of Molecular Chaperone Inhibition Facilitate Activation of Eukaryotic Initiation Factor-2 Kinase in Response to Endoplasmic Reticulum Stress*

Journal of Biological Chemistry, 2002
Phosphorylation of eukaryotic initiation factor-2 (eIF2) by pancreatic eIF2 kinase (PEK), induces a program of translational expression in response to accumulation of malfolded protein in the endoplasmic reticulum (ER).
Kun Ma, K. Vattem, R. Wek
semanticscholar   +1 more source

The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2.

Journal of Biological Chemistry, 1988
Guanine nucleotide exchange factor (GEF) is a multisubunit protein involved in the initiation of translation. Although numerous models have been proposed for its mechanism of action, none have been definitive.
A. Rowlands, R. Panniers, E. Henshaw
semanticscholar   +1 more source

Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling

eLife, 2016
Internal ribosome entry sites (IRESs) are important RNA-based translation initiation signals, critical for infection by many pathogenic viruses. The hepatitis C virus (HCV) IRES is the prototype for the type 3 IRESs and is also invaluable for exploring ...
Zane A Jaafar, Akihiro Oguro, Yoshikazu Nakamura, Jeffrey S Kieft   +3 more
doaj   +1 more source