Results 71 to 80 of about 162,301 (268)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Distributed Event-Triggered Control for Frequency Restoration in Islanded Microgrids with Reduced Trigger Condition Checking

CSEE Journal of Power and Energy Systems
For islanded microgrids (MGs), distributed control is regarded as a preferred alternative to centralized control for the frequency restoration of MGs. However, distributed control with successive communication restricts the efficiency and resilience of ...
Yulin Chen, Donglian Qi, Zhenming Li, Zhenyu Wang, Xinyi Yang, Jianliang Zhang   +5 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Event-Triggered Control for the Stabilization of Probabilistic Boolean Control Networks

Complexity, 2018
This paper realizes global stabilization for probabilistic Boolean control networks (PBCNs) with event-triggered state feedback control (ETSFC). Via the semitensor product (STP) of matrices, PBCNs with ETSFC are converted into discrete-time algebraic ...
Shiyong Zhu, Jungang Lou, Yang Liu, Yuanyuan Li, Zhen Wang   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Event-Triggered Fuzzy-Networked Control System for a 3-DOF Quadcopter with Limited-Bandwidth Communication

Applied System Innovation
Quadcopters are attracting widespread attention due to their growing demand for use in various applications. Since wired communication would severely restrict a quadcopter’s range, maneuverability, and applications, quadcopters usually communicate via ...
Ti-Hung Chen
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Event-triggered proportional-derivative control for nonlinear network systems with a novel event-triggering scheme: Differential of triggered state consideration

Advances in Mechanical Engineering, 2017
This article proposes event-triggered proportional-derivative control for a class of nonlinear network control systems. For derivative action of the proposed proportional-derivative control, a novel event-triggering scheme is devised together with the ...
Baeyoung Koo, Wookyong Kwon, Sangmoon Lee, Chongsoo Lee   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source