Results 81 to 90 of about 1,854,423 (305)

Incompatibility and interchangeability in molecular evolution

Genome Biology and Evolution, 2022
There is remarkable variation in the rate at which genetic incompatibilities in molecular interactions accumulate. In some cases, minor changes – even single nucleotide substitutions – create major epistatic incompatibilities when hybridization forces new variants to function in a novel genetic background from an isolated population.
Daniel B Sloan, Jessica M Warren, Alissa M Williams, Shady A Kuster, Evan S Forsythe   +4 more
openaire   +2 more sources

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, EarlyView.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

Major Changes in Plastid Protein Import and the Origin of the Chloroplastida

iScience, 2020
Summary: Core components of plastid protein import and the principle of using N-terminal targeting sequences are conserved across the Archaeplastida, but lineage-specific differences exist.
Michael Knopp, Sriram G. Garg, Maria Handrich, Sven B. Gould   +3 more
doaj  

Cytosolic‐enhanced dark Epac‐based FRET sensors allow for intracellular cAMP detection in live cells via FLIM

FEBS Letters, EarlyView.
We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti, Jeffrey B. Klarenbeek, Kees Jalink   +2 more
wiley   +1 more source

Task-specific odorant receptor expression in worker antennae indicates that sensory filters regulate division of labor in ants

Communications Biology, 2023
Division of labor (DOL) is a characteristic trait of insect societies, where tasks are generally performed by specialized individuals. Inside workers focus on brood or nest care, while others take risks by foraging outside.
Marcel A. Caminer, Romain Libbrecht, Megha Majoe, David V. Ho, Peter Baumann, Susanne Foitzik   +5 more
doaj   +1 more source

Evolution and Fragmentation of Wide-Angle Wind Driven Molecular Outflows [PDF]

, 2004
We present two dimensional cylindrically symmetric hydrodynamic simulations and synthetic emission maps of a stellar wind propagating into an infalling, rotating environment. The resulting outflow morphology, collimation and stability observed in these simulations have relevance to the study of young stellar objects, Herbig-Haro jets and molecular ...
arxiv   +1 more source

Molecular gas in nearby elliptical radio galaxies [PDF]

AIP Conf.Proc.1035:132-134,2008, 2008
Powerful radio-AGN are hosted by massive elliptical galaxies which are usually very poor in molecular gas. Nevertheless the central Black Hole (BH) needs molecular gas for the nuclear activity. Thus it is important to study the origin, the distribution and the kinematics of the molecular gas in such objects.
arxiv   +1 more source

A complete ancient RNA genome : identification, reconstruction and evolutionary history of archaeological Barley Stripe Mosaic Virus [PDF]

, 2014
The origins of many plant diseases appear to be recent and associated with the rise of domestication, the spread of agriculture or recent global movements of crops.
Allaby, Robin G., Clapham, Alan J., Liu, Yuan, Rose, Pam, Smith, Oliver, Wang, Jun   +5 more
core   +1 more source

Unpredictable repeatability in molecular evolution

Proceedings of the National Academy of Sciences, 2022
The extent of parallel evolution at the genotypic level is quantitatively linked to the distribution of beneficial fitness effects (DBFE) of mutations. The standard view, based on light-tailed distributions (i.e. distributions with finite moments), is that the probability of parallel evolution in duplicate populations is inversely proportional to the ...
Suman G. Das, Joachim Krug
openaire   +3 more sources

Diphthamide synthesis is linked to the eEF2‐client chaperone machinery

FEBS Letters, EarlyView.
The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr, Klaus Mayer, Raffael Schaffrath, Johannes Buchner, Ulrich Brinkmann   +4 more
wiley   +1 more source