Results 71 to 80 of about 242,368 (323)

Observational study on the impact of initiating tiotropium alone versus tiotropium with fluticasone propionate/salmeterol combination therapy on outcomes and costs in chronic obstructive pulmonary disease

Respiratory Research, 2012
Background This retrospective cohort study compared the risks of exacerbations and COPD-related healthcare costs between patients with chronic obstructive pulmonary disease (COPD) initiating tiotropium (TIO) alone and patients initiating triple therapy ...
Chatterjee Arjun, Shah Manan, D'Souza Anna O, Bechtel Benno, Crater Glenn, Dalal Anand A   +5 more
doaj   +1 more source

An overview of exacerbations of chronic obstructive pulmonary disease: Can tests of small airways' function guide diagnosis and management?

Annals of Thoracic Medicine, 2020
Chronic obstructive pulmonary disease (COPD) is common and debilitating. Most patients with COPD experience intermittent, acute deterioration in symptoms which require additional therapy, termed exacerbations.
Nowaf Y Alobaidi, James A Stockley, Robert A Stockley, Elizabeth Sapey   +3 more
doaj   +1 more source

Treatment guided by fractional exhaled nitric oxide in addition to standard care in 6- to 15-year-olds with asthma: the RAACENO RCT

Efficacy and Mechanism Evaluation, 2022
Background: The role of fractional exhaled nitric oxide in guiding asthma treatment in children is uncertain. Objective: To compare treatment guided by both fractional exhaled nitric oxide and symptoms (intervention) with treatment guided by symptoms ...
Steve Turner, Seonaidh Cotton, Jessica Wood, Victoria Bell, Edwin-Amalraj Raja, Neil W Scott, Heather Morgan, Louisa Lawrie, David Emele, Charlotte Kennedy, Graham Scotland, Shona Fielding, Graeme MacLennan, John Norrie, Mark Forrest, Erol Gaillard, Johan de Jongeste, Marielle Pijnenburg, Mike Thomas, David Price   +19 more
doaj   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Cahill's Cosmological Model Exacerbates The Primordial Lithium Problem And Creates New Problems For Primordial Deuterium And Helium [PDF]

arXiv, 2010
In a recent article R. T. Cahill claims that the cosmological model based on his "new physics of a dynamical 3-space" resolves the CMB-BBN Lithium-7 and Helium-4 abundance anomalies. In this note it is shown that this conclusion is wrong, resulting from a misunderstanding.
arxiv  

Conundrum in an asthma exacerbation [PDF]

BMJ Case Reports, 2016
A 66-year-old man, an asthmatic, presented with symptoms suggestive of an acute exacerbation of asthma. His arterial blood gas revealed type 1 respiratory failure (PaO2<8 kPa or 60 mm Hg with normal or low PaCO2) with a compensated lactic acidosis. He was treated for an asthma exacerbation and sepsis. Despite treatment, his respiratory rate remained
Thomas McLellan, Bernard Yung, Barney Isaac, Johnson Samuel   +3 more
openaire   +3 more sources

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Lost in Translation: Loss and Decay of Linguistic Richness in Machine Translation [PDF]

arXiv, 2019
This work presents an empirical approach to quantifying the loss of lexical richness in Machine Translation (MT) systems compared to Human Translation (HT). Our experiments show how current MT systems indeed fail to render the lexical diversity of human generated or translated text.
arxiv  

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4

FEBS Open Bio, EarlyView.
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang, Yukun Xu, Yujia Li, Yiming Pang, Xueting Ding, Raorao Zhou, Dan Liang, Xianda Che, Yuanyu Zhang, Chunfang Wang, Wenjin Li, Pengcui Li   +11 more
wiley   +1 more source

“Frequent exacerbator” is a phenotype of poor prognosis in Japanese patients with chronic obstructive pulmonary disease

International Journal of COPD, 2016
Ryusuke Tomioka,1,2 Tomotaka Kawayama,1 Masashi Suetomo,1,2 Takashi Kinoshita,1 Yoshihisa Tokunaga,1 Haruki Imaoka,1 Kazuko Matsunaga,1 Masaki Okamoto,1 Tomoaki Hoshino1 1Division of Respirology, Neurology, and Rheumatology, Department of Medicine ...
Tomioka R, Kawayama T, Suetomo M, Kinoshita T, Tokunaga Y, Imaoka H, Matsunaga K, Okamoto M, Hoshino T   +8 more
doaj