Results 161 to 170 of about 2,961,092 (275)

Glutamatergic Modulators in Schizophrenia: Are We Ready to Move Beyond the Narrow Focus on Dopamine? A Potential Paradigm Shift in Psychopharmacology. [PDF]

Alpha Psychiatry
de Filippis R, Guinart D, Correll CU, Liparota G, Kishimoto T, De Fazio P.   +5 more
europepmc   +1 more source

Stretchable, Tough, and Luminescent Perovskite Molecular Ferroelectric Composite: Empowering Reliable Self‐Powered Motion Sensing in High Humidity and Subzero Temperatures

Advanced Science, EarlyView.
A flexible molecular ferroelectric composite is fabricated via in situ growth of luminescent DMAA‐MnCl3 ferroelectric crystals within a SEBS/SIS double‐polymer matrix. It delivers 7.54 MPa tensile strength, over 1200% tensile strain, durable piezoelectric motion sensing, and excellent harsh‐environment stability for all‐weather wearable biomechanical ...
Shuangqing Li, Zhe‐Kun Xu, Zheng Xing, Jin‐Wang Liu, Yong‐Quan Wu, Peng‐Fei Li, Zhong‐Xia Wang   +6 more
wiley   +1 more source

Therapeutic Potential of Oxiracetam in Neurocognitive Disorders: A Narrative Review. [PDF]

Brain Behav
Ali H, Maliha S, Ishtiaq S, Al-Karawi O, Amin MHJ.   +4 more
europepmc   +1 more source

Spatiotemporally Ultrasound‐Controlled Nanoparticles Reprogramming Immunostimulatory Antigen‐Presenting Cancer‐Associated Fibroblasts to Enhance Cancer Immunotherapy

Advanced Science, EarlyView.
We developed an ultrasound‐controlled biomimetic nanoplatform, mRNA/V@M NPs, to co‐deliver CD74 mRNA and V‐9302 for fibrotic TNBC therapy. CD74 mRNA reprograms myCAFs into antigen‐presenting apCAF cells through the CD74‐MHC II pathway, while V‐9302 induces ICD and activates MHC I‐CD8+ T cell immunity.
Chen Ai, Weikai Sun, Yuxuan Zhao, Daqian Sun, Ting Meng, Yafei Qi, Fengyang Jiang, Jintang Sun, Zhiliang Gao, Dexin Yu   +9 more
wiley   +1 more source

Subarachnoid hemorrhage mediates human neocortical network, membrane potential, and action potential bursting via glutamate receptors. [PDF]

Commun Biol
Huang DF, Chou MY, Lee YH, Chen YT, Sun CK, Wang KC, Huang HS.   +6 more
europepmc   +1 more source

Synchronized Imaging of Hydrogen Peroxide and Hydroxyl Radical in Pyroptosis and Epilepsy

Advanced Science, EarlyView.
A dual‐responsive fluorescent probe, HH, enables synchronized visualization of H2O2 and •OH through spectrally resolved green and red channels. By tracking redox dynamics in pyroptosis and epilepsy models, HH reveals ROS elevation during seizure‐like pathology and supports evaluation of antioxidant and antiepileptic therapeutic interventions.
Yabing Gan, Yuling Xu, Ting Yu, Yang Li, Xin Jiang, Haoyu Jin, Haitao Li, Youyu Zhang, Peng Yin, Jong Seung Kim   +9 more
wiley   +1 more source

The prefrontal cortex as a target of HIV-1 neurotoxicity: molecular mechanisms of viral protein-mediated neurodegeneration and executive dysfunction. [PDF]

Front Cell Neurosci
Honsa ES.
europepmc   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Natural Products as GPCR-Targeting Antidepressant Candidates: Advances and Opportunities. [PDF]

Pharmaceuticals (Basel)
Li H, He X, Cao T, Huang J, Chen B, Xu L, Yang Y, Li G, Xiong L.   +8 more
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source