Results 181 to 190 of about 44,108 (332)

The role of excitatory amino acid receptors in the basal forebrain in the locomotor response produced by psychostimulants and the non-competitive NMDA receptor antagonist MK801 /

, 1992
David L. Willins
openalex   +1 more source

EFFECT OF THE EXCITATORY AMINO ACID ANTAGONIST MK-801 ON NEUROLOGIC FUNCTION FOLLOWING COMPLETE CEREBRAL ISCHEMIA IN PRIMATES [PDF]

, 1988
William L. Lanier, William J. Perkins, Bent Ole Ruud, James H. Milde, John D. Michenfelder   +4 more
openalex   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Cancer Neuroscience: Linking Neuronal Plasticity with Brain Tumor Growth and Resistance. [PDF]

Biology (Basel)
Khafaga DSR, Basem Y, AlAtar HM, Sherif A, Ata A, Sabry F, El-Morsy MT, Attia SS.   +7 more
europepmc   +1 more source

The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence

Advanced Science, EarlyView.
This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang, Jingrui Wang, Qiaowan Chen, Chen Jiao, Yun Chen, Zhongshou Wu, Zhonghua Ma   +6 more
wiley   +1 more source

Galanin Receptors in the Central Nervous System: Exploring Ligand Interactions, Signal Transduction, and Potential Clinical Implications. [PDF]

Molecules
Owczarek A, Blecharz-Klin K.
europepmc   +1 more source

Non-competitive NMDA receptor antagonists moderate seizure-induced c-fos expression in the rat cerebral cortex [PDF]

, 2003
Krisztin-Péva Beáta, Mihály András, Szakács Réka, Weiczner Roland, Zádor Ernő, Zádor Zsolt   +5 more
core   +1 more source

A Dual‐Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor‐Associated Osteolysis Restoration via Sequential Release

Advanced Science, EarlyView.
The versatile CaO2@CuMOF@HAP nanohybrid demonstrates an outstanding MMP9/pH‐triggered release performance for sequential release of osteogenic growth peptide into deep‐seated tumor‐infiltrated bone destruction areas and dual ions into tumor cells, enabling efficient tumor‐associated osteolysis restoration and tumor elimination for more comprehensive ...
Lan Liu, Han‐Zhe Liu, Zhe‐Nan Liu, Tong Wang, Li‐Li Yu, Qiu‐Jing Li, Zi‐Yi Chen, Guo‐Feng Luo, Zheng‐Jun Shang   +8 more
wiley   +1 more source

Astrocyte-neuron interaction in the substantia gelatinosa of the spinal cord dorsal horn via P2X7 receptor-mediated release of glutamate and reactive oxygen species [PDF]

, 2014
Andó, Rómeó, Ficker, Christoph, Illés, Péter, Kató, Erzsébet, Rozmer, Katalin, Schumann, Luisa, Sperlágh, Beáta   +6 more
core   +1 more source

THE CEREBRAL AND SYSTEMIC EFFECTS OF THE EXCITATORY AMINO ACID RECEPTOR ANTAGONIST MK-801 IN DOGS [PDF]

, 1988
William J. Perkins, William L. Lanier, Bent Ole Ruud, James H. Milde   +3 more
openalex   +1 more source