Results 201 to 210 of about 25,139 (242)
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Neurotoxicity and excitatory amino acid antagonists.
Neurotoxicology, 1995The cytotoxic action of excitatory amino acids (glutamate, aspartate, NMDA, AMPA, and kainate) was studied in cultured neocortical neurons. It was demonstrated that all amino acids triggered an increase in the intracellular Ca2+ concentration which appeared to be prerequisite for their cytotoxic action.
A, Schousboe +3 more
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Interaction of ethanol with excitatory amino acid receptor antagonists in mice
European Journal of Pharmacology, 1999The purpose of the present study was to determine whether the motor impairment (myorelaxation/ataxia) induced by excitatory amino acid receptor antagonists was exaggerated by pretreatment with ethanol. The results were compared with those of gamma-aminobutyric acid(A) (GABA(A)) receptor positive modulators alone and in combination with ethanol.
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Role of Excitatory Amino Acid Antagonists in the Management of Birth Asphyxia
Biology of the Neonate, 2009Birth asphyxia is an important cause of permanent neuro-developmental disability. Asphyxia sets in course a progression of intracellular events which culminates in neuronal death, and this process may take up to 48 h to complete. Entry of calcium into the neurone appears to be the key to the cell death, and it is known that during asphyxia, excessive ...
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Excitatory amino acid agonists and antagonists: pharmacology and therapeutic applications
Pharmaceutica Acta Helvetiae, 2000Glutamic acid is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). Specific receptors bind glutamate and some of these when activated open an integral ion channel and are thus known as ionotropic receptors. Within the ionotropic family of glutamate receptors, three major subtypes have been identified using classical ...
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Non-competitive antagonists of excitatory amino acid receptors
Trends in Neurosciences, 1987Abstract Non-competitive antagonists have become important tools for investigating the basic mechanisms of NMDA receptor function. Such compounds (e.g. MK-801, PCP) are thought to act at the level of the NMDA receptor-associated ion channel and many show a marked use-dependence in their antagonist properties.
John A. Kemp +2 more
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Neuroscience Letters, 1984
Intracellular recordings of neurally evoked excitatory junction potentials were made from the hermit crab neuromuscular junction and the effects of a series of putative antagonists, including the phosphonic amino acids, were examined for their effectiveness.
A E, King, H V, Wheal
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Intracellular recordings of neurally evoked excitatory junction potentials were made from the hermit crab neuromuscular junction and the effects of a series of putative antagonists, including the phosphonic amino acids, were examined for their effectiveness.
A E, King, H V, Wheal
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Possible Therapeutic Applications of Antagonists of Excitatory Amino acid Neurotransmitters
Clinical Science, 1985The dicarboxylic amino acids, glutamate and aspartate, are excitatory neurotransmitters in many brain regions. Recent animal experiments with analogues of dicarboxylic amino acids that block their excitatory actions, suggest that such selective antagonists could have important therapeutic uses in neurology and psychiatry.
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Protective role of excitatory amino acid antagonists in experimental retinal ischemia
Graefe's Archive for Clinical and Experimental Ophthalmology, 1995Excitatory amino acids and their analogues (NMDA, kainate and AMPA) are implicated in the pathogenesis of ischemic brain injury. In order to fully understand their involvement in the pathogenesis of retinal ischemic injury, we studied the electrophysiological and histopathological effects of two excitatory amino acid antagonists, cis-PDA and MK 801, in
M, Weber, N, Bonaventure, J A, Sahel
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Hyperpolarization of retinal horizontal cells by excitatory amino acid neurotransmitter antagonists
Neuroscience Letters, 1982Membrane potentials of retinal horizontal cells have been recorded fro isolated fish retinae perfused with Ringer solutions containing various drugs. We show that glutamate diethyl ester (GDEE) and gamma-D-glutamylglycine (DGG), respectively antagonists of the excitatory neurotransmitter agonists quisqualate and kainate, hyperpolarize horizontal cells ...
J S, Rowe, K H, Ruddock
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Blockade of hyperbaric oxygen induced seizures by excitatory amino acid antagonists
Canadian Journal of Physiology and Pharmacology, 1985The effectiveness of several excitatory amino acid antagonists to delay or block seizures induced by oxygen at high pressure was examined in mice. Of the antagonists tested, namely, L-proline, DL-α-aminoadipate, DL-2-amino-5-phosphonovalerate, and L-glutamic acid diethyl ester, DL-2-amino-5-phosphonovalerate was the most effective in delaying or ...
C A, Colton, J S, Colton
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