Multiplexed neurochemical monitoring reveals glutamate modulates dopamine neurotransmission in the nucleus accumbens. [PDF]
Donarski ED, Connors SS, Venton BJ.
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Targeting N-methyl-D-aspartate 2B receptor in painful diabetic neuropathy - mechanisms, challenges, and emerging therapeutics. [PDF]
Khalid N +4 more
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Infant traumatic brain injury with a biphasic clinical course and late diffusion restriction: a case report. [PDF]
He D, Yan R, Zhang P, Yue X, Xiao S.
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P2X7 receptor-dependent microglia-astrocyte coupling in Alzheimer's disease: from eATP sensing to synaptic and proteostatic failure. [PDF]
Li Y, Liu S, Lan J.
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Heterosynaptic NMDA receptor plasticity in hippocampal dentate granule cells. [PDF]
Nasrallah K +4 more
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Molecular and neural circuit mechanisms of parvalbumin (PV) neurons in depression: Insights and advances. [PDF]
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Robust serotonin activation of the kisspeptin GnRH pulse generator in male and female mice.
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Muscle relaxant action of excitatory amino acid antagonists
Neuroscience Letters, 1985Antagonists of neuronal excitation induced by dicarboxylic amino acids were tested in genetically spastic rats of the Han-Wistar strain. These animals exhibit an increased muscle tone which can be measured as a spontaneous tonic activity in the electromyogram of the gastrocnemius-soleus muscle. Compounds that block excitation due to N-methyl-D-aspartic
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Clinical Experience With Excitatory Amino Acid Antagonist Drugs
BackgroundExcitotoxic damage due to excess release of neuronal glutamate is hypothesized to play a pivotal role in the pathogenesis of focal cerebral ischemia. Drugs that antagonize excitatory amino acid function are consistently neuroprotective in preclinical models of stroke, and many are now entering clinical trials.SummaryAntagonists of theN-methyl-
K W, Muir, K R, Lees
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