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Depression of decerebrate rigidity in the rat by antagonists of excitatory amino acids
Neuropharmacology, 1989Effects of intravenous antagonists of excitatory amino acids on decerebrate rigidity in the rat were examined. Kynurenate, ketamine, (4S, 5R)-4-(2-methylpropyl)-3-[3-(perhydroazepin-1-yl)propyl]-5-phenyl- 1,3- oxazolidin-2-one hydrochloride (MLV-6976), (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclo-hepten-5,10-imine maleate (MK-801), 3-((/-)-2 ...
H, Shinozaki, M, Ishida, Y, Goto
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Neurotoxicity and excitatory amino acid antagonists.
Neurotoxicology, 1995The cytotoxic action of excitatory amino acids (glutamate, aspartate, NMDA, AMPA, and kainate) was studied in cultured neocortical neurons. It was demonstrated that all amino acids triggered an increase in the intracellular Ca2+ concentration which appeared to be prerequisite for their cytotoxic action.
A, Schousboe +3 more
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Antagonists of excitatory amino acids and cyclic guanosine monophosphate in cerebellum
Neuropharmacology, 1982The excitatory amino acid analogues kainate, quisqualate, domoic acid, 4-fluoroglutamate, homocysteic acid and N-methylaspartate as well as the tremor-inducing drugs harmaline and oxotremorine all induced significant elevations in cyclic guanosine monophosphate (cGMP) levels in the cerebellum in vivo. The putative antagonists of excitatory amino acids,
P L, Wood +3 more
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Methyltetrahydrofolate as an antagonist of excitatory amino acids on spinal neurones
European Journal of Pharmacology, 1982Folate and N5-methyl-5,6,7,8-tetrahydrofolate (MTHF) have been reported to have excitatory effects upon cortical neurones, possibly due to interaction with kainate receptors. On spinal neurones these compounds have been found inactive as excitants; however MTHF is a weak antagonist of kainate and N-methyl-D-aspartate excitations, and less effectively ...
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Excitatory amino acid receptor subtypes and specific antagonists
Medicinal Research Reviews, 1989Article de synthese sur le site de reconnaissance des recepteurs, le ionophore, l'unite modulatrice, les determinations du poids moleculaire, les ...
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Action of excitatory amino acids and their antagonists on hippocampal neurons
Cellular and Molecular Neurobiology, 1985Intracellular recordings were obtained from guinea pig hippocampal neurons maintained in vitro. Current- and voltage-clamp techniques were used to study the effect of microiontophoresis of excitatory amino acid agonists. Modification of agonist responses by bath application of known concentrations of antagonist agents was also examined.
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Excitatory amino acid antagonists and epilepsy
Biochemical Society Transactions, 1993A G, Chapman, B S, Meldrum
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Interaction of ethanol with excitatory amino acid receptor antagonists in mice
European Journal of Pharmacology, 1999The purpose of the present study was to determine whether the motor impairment (myorelaxation/ataxia) induced by excitatory amino acid receptor antagonists was exaggerated by pretreatment with ethanol. The results were compared with those of gamma-aminobutyric acid(A) (GABA(A)) receptor positive modulators alone and in combination with ethanol.
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Role of Excitatory Amino Acid Antagonists in the Management of Birth Asphyxia
Biology of the Neonate, 2009Birth asphyxia is an important cause of permanent neuro-developmental disability. Asphyxia sets in course a progression of intracellular events which culminates in neuronal death, and this process may take up to 48 h to complete. Entry of calcium into the neurone appears to be the key to the cell death, and it is known that during asphyxia, excessive ...
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