Results 221 to 230 of about 2,961,092 (275)

Agonists and antagonists for excitatory amino acid receptors

Trends in Neurosciences, 1987
Abstract Behind the recent explosion of interest in the field, there lies a long period of relatively slow progress in the characterization of excitatory amino acid receptors. In this article, Jeff Watkins and Harry Olverman summarize the emergence of current ideas relating to receptor differentiation and describe some of the molecular features of ...
J C Watkins
exaly   +2 more sources

Interactions of excitatory amino acid antagonists with conventional antiepileptic drugs

Metabolic Brain Disease, 1996
Excitatory amino acid antagonists possess anticonvulsant properties in many experimental models of epilepsy and were shown to potentiate the protective activity of conventional antiepileptics against maximal electroshock-induced seizures in mice. Combined treatments of valproate with either D,L-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid or ...
Waldemar Turski, Stanislaw Czuczwar, Zdzislaw Kleinrok   +2 more
exaly   +3 more sources

Excitatory amino acid antagonists induce a phencyclidine-like catalepsy in pigeons: Structure-activity studies☆ [PDF]

Neuropharmacology, 1987
The excitatory amino acid antagonists -2-amino-5-phosphonovalerate (-AP5), its isomers -(-)-AP5 and -(+)-AP5, -2-amino-4-phosphonobutyrate (AP4), -2-amino-7-phosphonoheptanoate (AP7), [beta]--aspartylaminomethylphosphonic acid (ASP-AMP), cis-2,3 ...
J H Woods, W Koek, A E Jacobson
exaly   +2 more sources

Noncompetitive excitatory amino acid receptor antagonists

Trends in Pharmacological Sciences, 1990
In the first article in this series, Watkins, Krogsgaard-Larsen and Honoré outlined the structure-activity requirements at the receptor sites for excitatory amino acids in the mammalian CNS. The postsynaptic depolarizing actions of glutamate are thought to be mediated by NMDA, AMPA and kainate receptors. Here David Lodge and Kenneth M.
D, Lodge, K M, Johnson
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Isomers of cyclazocine as excitatory amino acid antagonists

Neuropeptides, 1984
Abstract As an N-methylaspartate antagonist on cat and frog spinal neurones, (−) cyclazocine was twice as potent as (+) cyclazocine. This stereoselectivity is similar to that of cyclazocine at sigma rather than at mu or kappa opiate receptors. Cyclazocine also reduced synaptic excitation in rat cortex.
D, Lodge, S C, Berry, J, Church, D, Martin, A, McGhee, H M, Lai, A M, Thomson   +6 more
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Anticonvulsant Action of Excitatory Amino Acid Antagonists

Science, 1982
Compounds that antagonize neuronal excitation induced by dicarboxylic amino acids were tested in two animal models of epilepsy, namely sound-induced seizures in DBA/2 mice and threshold pentylenetetrazol seizures in Swiss mice. Sound-induced seizures could be prevented by intracerebroventricular injection of compounds that block excitation due to N ...
Croucher, M J, Collins, J F, Meldrum, B S   +2 more
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6 Excitatory amino acid antagonists

Baillière's Clinical Anaesthesiology, 1996
Summary l -glutamate is a major excitatory neurotransmitter in the mammalian central nervous system. It acts through ion channel receptors of the AMPA and NMDA subtypes, and selective antagonists acting on these receptors are available. Both in vitro and in vivo animal studies have demonstrated that glutamate antagonists, particularly those acting ...
Leslie L. Iversen, Kennedy R. Lees
openaire   +1 more source

Overview: Excitatory Amino Acid Antagonists

Current Opinion on Therapeutic Patents, 1992
(1992). Overview: Excitatory Amino Acid Antagonists. Current Opinion on Therapeutic Patents: Vol. 2, No. 8, pp. 1201-1221.
Michael Rowley, Paul D Leeson
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Excitatory Amino Acid Antagonists as Novel Anticonvulsants

1986
The convulsant effect of application of dicarboxylic amino acids to the cortex was first reported by Hayashi (1954). This observation suggests that antagonists of excitation induced by amino acid neurotransmitters might be anticonvulsant agents in some forms of epilepsy. Some rather weak and indeterminate anticonvulsant effects of glutamic acid diethyl
openaire   +2 more sources

Neuroprotective Actions of Excitatory Amino Acid Receptor Antagonists

1994
Publisher Summary Postischemic neuronal degeneration is caused in part by overactivity of excitatory amino acid (EAA) neurotransmitter systems. Increases in extracellular glutamate levels result in glutamate receptor-mediated increases in postsynaptic intracellular calcium levels.
V L, Woodburn, G N, Woodruff
openaire   +2 more sources