Results 191 to 200 of about 25,139 (242)
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Clinical Experience With Excitatory Amino Acid Antagonist Drugs
Stroke, 1995BackgroundExcitotoxic damage due to excess release of neuronal glutamate is hypothesized to play a pivotal role in the pathogenesis of focal cerebral ischemia. Drugs that antagonize excitatory amino acid function are consistently neuroprotective in preclinical models of stroke, and many are now entering clinical trials.SummaryAntagonists of theN-methyl-
K W, Muir, K R, Lees
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Agonists and antagonists for excitatory amino acid receptors
Trends in Neurosciences, 1987Abstract Behind the recent explosion of interest in the field, there lies a long period of relatively slow progress in the characterization of excitatory amino acid receptors. In this article, Jeff Watkins and Harry Olverman summarize the emergence of current ideas relating to receptor differentiation and describe some of the molecular features of ...
J.C. Watkins, H.J. Olverman
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Neuroprotective Actions of Excitatory Amino Acid Receptor Antagonists
1994Publisher Summary Postischemic neuronal degeneration is caused in part by overactivity of excitatory amino acid (EAA) neurotransmitter systems. Increases in extracellular glutamate levels result in glutamate receptor-mediated increases in postsynaptic intracellular calcium levels.
V L, Woodburn, G N, Woodruff
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Depression of decerebrate rigidity in the rat by antagonists of excitatory amino acids
Neuropharmacology, 1989Effects of intravenous antagonists of excitatory amino acids on decerebrate rigidity in the rat were examined. Kynurenate, ketamine, (4S, 5R)-4-(2-methylpropyl)-3-[3-(perhydroazepin-1-yl)propyl]-5-phenyl- 1,3- oxazolidin-2-one hydrochloride (MLV-6976), (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclo-hepten-5,10-imine maleate (MK-801), 3-((/-)-2 ...
H, Shinozaki, M, Ishida, Y, Goto
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Antagonists of excitatory amino acids and cyclic guanosine monophosphate in cerebellum
Neuropharmacology, 1982The excitatory amino acid analogues kainate, quisqualate, domoic acid, 4-fluoroglutamate, homocysteic acid and N-methylaspartate as well as the tremor-inducing drugs harmaline and oxotremorine all induced significant elevations in cyclic guanosine monophosphate (cGMP) levels in the cerebellum in vivo. The putative antagonists of excitatory amino acids,
P L, Wood +3 more
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Structure-activity relations of dipeptide antagonists of excitatory amino acids
Neuroscience, 1984Structure-activity relations of dipeptides related to gamma-D-glutamylglycine have been investigated with respect to the ability of these substances to antagonize depolarizing responses of frog motoneurones in vitro to N-methyl-D-aspartate, kainate and quisqualate.
A W, Jones, D A, Smith, J C, Watkins
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Excitatory Amino Acid Antagonists as Novel Anticonvulsants
1986The convulsant effect of application of dicarboxylic amino acids to the cortex was first reported by Hayashi (1954). This observation suggests that antagonists of excitation induced by amino acid neurotransmitters might be anticonvulsant agents in some forms of epilepsy. Some rather weak and indeterminate anticonvulsant effects of glutamic acid diethyl
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Excitatory amino acid receptor subtypes and specific antagonists
Medicinal Research Reviews, 1989Article de synthese sur le site de reconnaissance des recepteurs, le ionophore, l'unite modulatrice, les determinations du poids moleculaire, les ...
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Methyltetrahydrofolate as an antagonist of excitatory amino acids on spinal neurones
European Journal of Pharmacology, 1982Folate and N5-methyl-5,6,7,8-tetrahydrofolate (MTHF) have been reported to have excitatory effects upon cortical neurones, possibly due to interaction with kainate receptors. On spinal neurones these compounds have been found inactive as excitants; however MTHF is a weak antagonist of kainate and N-methyl-D-aspartate excitations, and less effectively ...
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Action of excitatory amino acids and their antagonists on hippocampal neurons
Cellular and Molecular Neurobiology, 1985Intracellular recordings were obtained from guinea pig hippocampal neurons maintained in vitro. Current- and voltage-clamp techniques were used to study the effect of microiontophoresis of excitatory amino acid agonists. Modification of agonist responses by bath application of known concentrations of antagonist agents was also examined.
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