Results 41 to 50 of about 402 (78)

Conversion of silent synapses to AMPA receptor-mediated functional synapses in human cortical organoids

open access: yesNeuroscience Research
Despite the crucial role of synaptic connections and neural activity in the development and organization of cortical circuits, the mechanisms underlying the formation of functional synaptic connections in the developing human cerebral cortex remain ...
Masatoshi Nishimura   +7 more
doaj  

TRPM4 blocking antibody reduces neuronal excitotoxicity by specifically inhibiting glutamate-induced calcium influx under chronic hypoxia

open access: yesNeurobiology of Disease
Excitotoxicity arises from unusually excessive activation of excitatory amino acid receptors such as glutamate receptors. Following an energy crisis, excitotoxicity is a major cause for neuronal death in neurological disorders. Many glutamate antagonists
Charlene P. Poore   +7 more
doaj  

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