Results 101 to 110 of about 177,492 (353)

A framework for generalized group testing with inhibitors and its potential application in neuroscience [PDF]

, 2019
The main goal of group testing with inhibitors (GTI) is to efficiently identify a small number of defective items and inhibitor items in a large set of items.
Bui, Thach V., Cheraghchi, Mahdi, Echizen, Isao, Kuribayashi, Minoru   +3 more
core   +1 more source

Single‐Nucleus RNA Sequencing Reveals Mid‐Gestational Neurodevelopment Features in the Superior Temporal Plane from Fetuses with Nonsyndromic Cleft Lip and Palate

Advanced Science, EarlyView.
Single‐nucleus RNA sequencing of mid‐gestation brains from fetuses with nonsyndromic cleft lip and palate reveals major disruptions in cell composition, cell‐to‐cell signaling, and gene regulation. The transcription factor MEF2C is identified as a central regulator of these changes and shows that lowering MEF2C impairs synapse formation, linking cleft ...
Liu‐Lin Xiong, Xin‐Wei Huang, Qiu‐Xia Xiao, Ying‐Gang Zheng, Hao‐Yue Qin, Chang‐Le Fang, Li Chen, Ruo‐Lan Du, Qiu‐Lin Wang, Li‐Ren Huangfu, Ye‐Qing Fei, Yang‐Yang Zhao, Chen‐Yang Zhai, Ze‐Mian Chen, Shi‐Kun Yuan, Yu‐Ji Zhou, Xing‐Man He, Ting‐Ting Zhi, Xiao‐He Tian, Ting‐Hua Wang   +19 more
wiley   +1 more source

Role of Connexin 36 in Autoregulation of Oxytocin Neuronal Activity in Rat Supraoptic Nucleus

ASN Neuro, 2019
In the supraoptic nucleus (SON), the incidence of dye coupling among oxytocin (OT) neurons increases significantly in nursing mothers. However, the type(s) of connexin (Cx) involved is(are) unknown.
Ping Wang, Stephani C. Wang, Dongyang Li, Tong Li, Hai-Peng Yang, Liwei Wang, Yu-Feng Wang, Vladimir Parpura   +7 more
doaj   +1 more source

Deep Neural Networks - A Brief History

, 2017
Introduction to deep neural networks and their history.Comment: 14 pages, 14 ...
AL Hodgkin, DH Hubel, DM Sala, EM Izhikevich, EM Izhikevich, GE Hinton, GE Hinton, HK Lim, JH Shin, K Fukushima, KJ Cios, T Kohonen, W Swiercz, WS McCulloch   +13 more
core   +1 more source

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, EarlyView.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Associative memory model with long-tail-distributed Hebbian synaptic connections

Frontiers in Computational Neuroscience, 2013
The postsynaptic potentials of pyramidal neurons have a non-Gaussian amplitude distribution with a heavy tail in both hippocampus and neocortex. Such distributions of synaptic weights were recently shown to generate spontaneous internal noise optimal ...
Naoki eHiratani, Naoki eHiratani, Jun-nosuke eTeramae, Jun-nosuke eTeramae, Tomoki eFukai, Tomoki eFukai, Tomoki eFukai   +6 more
doaj   +1 more source

The inhibition of evoked excitatory postsynaptic potentials produced by ammonium chloride in rat hippocampal CA1 neurons [PDF]

, 2020
Naomitsu Kameyama, Yoshinaka Murai, Eiichiro Tanaka   +2 more
openalex   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Persistent sodium current blockers can suppress seizures caused by loss of low‐threshold D‐type potassium currents: Predictions from an in silico study of Kv1 channel disorders

Epilepsia Open, 2020
Objective Ion channels belonging to subfamily A of voltage‐gated potassium channels (Kv1) are highly expressed on axons, where they play a key role in determining resting membrane potential, in shaping action potentials, and in modulating action ...
Jiaxin Du, Viktor Vegh, David C. Reutens
doaj   +1 more source

A Van Der Waals Broadband Infrared Optical Synapse Enabling Orientation Detection

Advanced Science, EarlyView.
An infrared optoelectronic synapse based on a graphene/CrOCl/graphene van der Waals heterostructure is reported to possess a broadband synaptic response range from the visible to the infrared (520–2000 nm), which can be used to achieve orientation and motion detections of a target mimicing the pit organ of a pit vapor.
Dan Guo, Wenjing Li, Pingfan Gu, Weikang Dong, Xuyan Rui, Kenji Watanabe, Takashi Taniguchi, Yu Ye, Fawei Zheng, Jiadong Zhou, Shoujun Zheng   +10 more
wiley   +1 more source