Results 101 to 110 of about 363,862 (308)

Loss of oligodendrocyte ErbB receptor signaling leads to hypomyelination, reduced density of parvalbumin‐expressing interneurons, and inhibitory function in the auditory cortex

Glia, Volume 71, Issue 2, Page 187-204, February 2023., 2023
Main Point Loss of oligodendrocyte ErbB receptor signaling leads to A1 hypomyelination, reduced PV expression and density of PV+ neurons and synapses, hypoconnectivity of inhibitory circuits and shift of the E/I balance towards excitation. Abstract For a long time, myelin was thought to be restricted to excitatory neurons, and studies on dysmyelination
Beatriz C. Borges, Xiangying Meng, Patrick Long, Patrick O. Kanold, Gabriel Corfas   +4 more
wiley   +1 more source

Inhibition of Cgkii Suppresses Seizure Activity and Hippocampal Excitation by Regulating the Postsynaptic Delivery of Glua1

Cellular Physiology and Biochemistry, 2018
Background/Aims: The imbalance between excitation and inhibition is a defining feature of epilepsy. GluA1 is an AMPA receptor subunit that can strengthen excitatory synaptic transmission when upregulated in the postsynaptic membrane, which has been ...
Juan Gu, Xin Tian, Wei Wang, Qin Yang, Peijia Lin, Yuanlin Ma, Yan Xiong, Demei Xu, Yanke Zhang, Yong Yang, Shanshan Lu, Zijun Lin, Jing Luo, Fei Xiao, Xuefeng Wang   +14 more
doaj   +1 more source

Gate‐Tunable Dual‐Mode Optoelectronic Device for Self‐Powered Photodetector and Optoelectronic Synapse

Advanced Science, EarlyView.
A gate‐tunable MoTe₂/MoS₂ heterostructure‐based dual‐mode optoelectronic device functions as both a self‐powered photodetector and an optoelectronic synapse. It leverages the photovoltaic effect for photodetection and trapping states for synaptic behavior. Gate modulation enables seamless switching, paving the way for integrating neuromorphic computing
Yi Ouyang, Chaoyi Zhang, Jun Wang, Zheng Guo, Zegao Wang, Mingdong Dong   +5 more
wiley   +1 more source

Deletion of MyD88 in astrocytes prevents β‐amyloid‐induced neuropathology in mice

Glia, Volume 71, Issue 2, Page 431-449, February 2023., 2023
Main Points MyD88 is upregulated in astrocytes in Alzheimer's disease. Deletion of MyD88 in astrocytes protects against β‐amyloid‐induced synaptic toxicity and cognitive impairment in mice. Abstract As the understanding of immune responses in Alzheimer's disease (AD) is in its early phases, there remains an urgency to identify the cellular and ...
Tee Jong Huat, Tessa Onraet, Judith Camats‐Perna, Estella A. Newcombe, Kim C. Ngo, Ashley N. Sue, Mehdi Mirzaei, Frank M. LaFerla, Rodrigo Medeiros   +8 more
wiley   +1 more source

Connectivity reflects coding: A model of voltage-based spike-timing-dependent-plasticity with homeostasis [PDF]

, 2009
Electrophysiological connectivity patterns in cortex often show a few strong connections in a sea of weak connections. In some brain areas a large fraction of strong connections are bidirectional, in others they are mainly unidirectional.
Claudia Clopath, Eleni Vasilaki, Lars Bü, Wulfram Gerstner   +3 more
core   +1 more source

Equilibrium Properties of Temporally Asymmetric Hebbian Plasticity [PDF]

, 2000
A theory of temporally asymmetric Hebb (TAH) rules which depress or potentiate synapses depending upon whether the postsynaptic cell fires before or after the presynaptic one is presented.
C. W. Eurich, Daniel D. Lee, G. Q. Bi, H. Markram, H. Sompolinsky, Jonathan Rubin, L. F. Abbott, M. C. W. van Rossum, R. Kempter, R. P. N. Rao, W. M. Kistler   +10 more
core   +4 more sources

Regulation of PVT‐CeA Circuit in Deoxynivalenol‐Induced Anorexia and Aversive‐Like Emotions

Advanced Science, EarlyView.
The study investigates Deoxynivalenol (DON) effects on feeding and emotions, focusing on the central amygdala (CeA). Acute DON exposure reduces food intake and alters behavior, linked to CeAGABA neuron activity and PVT‐CeA connectivity. Manipulating CeAGABA neurons and using SCN10A antagonist A‐803467 alleviate DON's effects, offering potential ...
Liu‐Nan Yang, Mingmeng Tang, Andreas K. Nüssler, Liegang Liu, Wei Yang   +4 more
wiley   +1 more source

AST-120 Protects Cognitive and Emotional Impairment in Chronic Kidney Disease Induced by 5/6 Nephrectomy

Brain Sciences
Background: Uremic toxins resulting from chronic kidney disease (CKD) can cause cognitive and emotional disorders, as well as cardiovascular diseases. Indoxyl sulfate (IS) and p-cresol are notable uremic toxins found in patients with CKD.
Yeon Hee Yu, Hyuna Im, Samel Park, Beomjong Song, Dae-Kyoon Park, Duk-Soo Kim, Hyo-Wook Gil   +6 more
doaj   +1 more source

Implementing Multimodal Hardware Security with 2D α‐In2Se3 Ferroelectric Transistor

Advanced Science, EarlyView.
A multimodal secure transistor‐integrated in‐memory sensing and computing architecture is demonstrated by leveraging its electronic and optoelectronic synaptic behaviors. Key security primitives, such as anticounterfeiting, watermarking, logic locking, and camouflaging, are implemented within a compact single‐transistor structure, providing a scalable ...
Xinwei Zhang, Jiachao Zhou, Yishu Zhang, Jian Chai, Yongqing Bai, Hailiang Wang, Qian He, Xi Wang, Lin Wang, Yuda Zhao, Yang Xu, Bin Yu   +11 more
wiley   +1 more source

Neuromorphic devices based on fluorite‐structured ferroelectrics

InfoMat, Volume 4, Issue 12, December 2022., 2022
Since the discovery of unexpected ferroelectricity in HfO2‐based thin film in 2011, ferroelectric memories have been proposed as highly promising candidates for neuromorphic computing devices. The recent progress on HfO2‐based ferroelectric synaptic devices or artificial spiking neurons, utilizing ferroelectric tunnel junctions and ferroelectric field ...
Dong Hyun Lee, Geun Hyeong Park, Se Hyun Kim, Ju Yong Park, Kun Yang, Stefan Slesazeck, Thomas Mikolajick, Min Hyuk Park   +7 more
wiley   +1 more source