Results 131 to 140 of about 174,824 (351)

Analyses of GWAS and Sub‐Threshold Loci Lead to the Discovery of Dendrite Development and Morphology Dysfunction Underlying Schizophrenia Genetic Risk

Advanced Science, EarlyView.
A cost‐effective strategy is developed analyzing sub‐threshold GWAS loci (5 × 10−8 < P ≤ 10−6), identifying 180 risk loci and 304 high‐confidence genes through combined GWAS/subGWAS analysis. This approach reveals dendrite development and morphogenesis (DDM) as a novel SCZ pathway.
Rui Chen, Benjamin Siciliano, Quan Wang, Chongchong Xu, Qiang Wei, Hai Yang, James S Sutcliffe, Yi Jiang, Ying Ji, Chunyu Liu, Feixiong Cheng, Edwin H Cook, Nancy J Cox, Xue Zhong, Zhexing Wen, Bingshan Li   +15 more
wiley   +1 more source

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

Advanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao, Feng He, Jin Ning, Guaiguai Ma, Xiaohua Chen, Haoxiang Xiao, Yuanyuan Zhu, Haifeng Zhang, Yifan Lu, Qian Liu, Meng Nian, Shiquan Sun, Shibin Yu, Shengxi Wu, Ze Fan, Zuolin Jin, Jing Huang   +19 more
wiley   +1 more source

A Floating‐Gate Photoelectric Synaptic Transistor Utilizing BP/POx/WSe2 Heterostructure for Neuromorphic Visual Processing

Advanced Science, EarlyView.
In this paper, a novel floating gate transistor (BP/POx/WSe2) is developed, which enables rich synaptic functionality under optoelectronic conditions and can mimic human visual memory. By introducing a two‐path convolutional neural network that synergistically fuses optical and electronic inputs, it can achieve efficient feature extraction and weight ...
Yuxuan Zeng, Wenxing Lv, Zehai Hou, Weihua Huang, Zhipeng Yu, Zishuo Han, Rongbin Zhan, Tianle Zeng, Yawen Luo, Yu Lin, Weiming Lv, Bin Fang, Zhongming Zeng, Lianbo Guo   +13 more
wiley   +1 more source

Excitatory amino acid transporters (EAATs) restrain nucleus tractus solitarii (nTS) activity induced by ionotropic and metabotropic glutamate receptor activation

Revista Cubana de Investigaciones Biomédicas, 2020
Introduction: Glutamate (Glu) is the primary excitatory amino acid neurotransmitter released from visceral afferents in the nTS. Glu binds to postsynaptic ionotropic glutamate receptors (iGluRs, AMPA or NMDA) to induce rapid phasic synaptic currents and ...
David D. Kline, Michael P. Matott, Diana Martinez   +2 more
doaj  

Artificial Nervous Systems

Advanced Science, EarlyView.
By drawing inspiration from biological neural hierarchies and the working mechanisms of plasticity, researchers have constructed a series of bionic devices, including sensory devices, synapse devices, and artificial neural systems. They committed to simulating and surpassing the biological information processing function, thereby realizing the ...
Lu Yang, Qingwen Cheng, Yue Li, Ning Wu, Zhipeng Xu, Wentao Xu   +5 more
wiley   +1 more source

The neuropharmacology of baclofen [PDF]

, 1988
AI Shapovalov, B Ault, B Ault, B Ault, B Ault, B Ault, B Sutor, B Sutor, BH Gähwiler, BH Gähwiler, BW Connors, CF Terrence, CG Swahn, CN Scholfield, CR Cain, D Stevens, DR Curtis, DR Curtis, DR Curtis, DR Gehlert, DR Hill, E Cherubini, E Knutsson, E Mugnaini, E Roberts, E Schlicker, EW Karbon, FK Pierau, FK Pierau, GAR Johnston, GE Fagg, GGS Collins, GP Wilkin, GW Price, H Fukuda, H Keberle, H Möhler, H Ono, HJ Bein, HL Haas, HR Olpe, HR Olpe, HR Olpe, J Davies, J Davies, J Davies, J Swaynok, JJ Dreifuss, JL Henry, JL Henry, JL Henry, JR Bianchine, JR Howe, JW Phillis, K Dunlap, K Koketsu, K Krnjevic, KJ Fotherby, KS Saito, M Desarmenien, M Fillenz, M Inoue, M Inoue, M Kato, MA Simmonds, MR Klee, N Auden, N Ogata, NG Bowery, NG Bowery, NG Bowery, NG Bowery, NR Newberry, NR Newberry, NR Newberry, P Ashby, P Krogsgaard-Larsen, P Polc, PR Wilson, R Benecke, R Capek, RA Davidoff, RD Pinnock, RF Schmidt, RH Evans, RJ Brady, RR Young, RW Birkmayer, S Fox, SJ Enna, SJ Potashner, SJ Potashner, SR Barry, SR Zukin, TH Lanthorn, TJ Blaxter, U Heinemann, U Misgeld, V Ben-Ari, W Haefely, W Haefely, W Laskey, W Laskey, W Zieglgänsberger, WJ Wojcik   +104 more
core   +1 more source

Novel Optoelectronic Reconfigurable Transistors Based on Graphene/VO2 Heterojunction for Efficient Neuromorphic Perception, Computation, and Storage

Advanced Science, EarlyView.
A novel optoelectronic reconfigurable neuromorphic transistor based on a graphene/VO2 heterojunction with inserted Au electrodes is proposed. It exhibits broad‐spectrum self‐powered photodetection capability ranging from 365 to 940 nm. Through bias control and electrode sizing strategies, multiple functions for switch, synapse, and storage are achieved,
Danke Chen, Yuning Li, Xiaoqiu Tang, Jingye Sun, Xuan Yao, Peizhi Yu, Xue Li, Qing You, Hanyu Wang, He Tian, Tao Deng   +10 more
wiley   +1 more source

2D Tellurene‐Based Optoelectronic Memristor with Temporal Dynamics for Multimodal Reservoir Computing System

Advanced Science, EarlyView.
The SPP‐treated Te‐based optoelectronic memristor demonstrates multimodal synaptic function in a single device under infrared optical and electrical stimuli. The multimode RC system is adept for processing sequence signals, including multisensory fusion and ECG pattern recognition.
Jingyao Bian, Zhuangzhuang Li, Shuang Liang, Ye Tao, Zhongqiang Wang, Yongxing Zhu, Changhua Wang, Haiyang Xu, Yichun Liu   +8 more
wiley   +1 more source

Enhanced Protein Synthesis and Hippocampus‐Dependent Memory via Inhibition of YTHDF2‐Mediated m6A mRNA Degradation

Advanced Science, EarlyView.
YTHDF2‐mediated m6A mRNA decay critically regulates learning and memory. Its forebrain‐specific knockout in mice impedes degradation of m6A‐modified mRNAs, enhancing hippocampal synaptic transmission, protein synthesis, and memory. Conversely, hippocampal YTHDF2 reintroduction or SEMA4B reduction reverses this enhancement, while its overexpression ...
Kuan Li, Chen Guo, Xiaoli Wu, Cuiting Wu, Songfen Wu, Si Su, Min Wu, Xidan Zhou, Si Li, Yihui Cui, Tao Zhou   +10 more
wiley   +1 more source

Research on Resistive Switching Mechanism of SnO2/SnS2 Based Heterojunction Memory Devices

Advanced Electronic Materials, EarlyView.
This work fabricates SnO2/SnS2 RRAM using (NH4)4Sn2S6, achieving 224 pJ set energy at 0.4 V with >1000‐cycle stability and 4 × 104 s retention. XPS/SEM/AFM‐validated interfacial engineering enables uniform switching, advancing low‐power neuromorphic memory development.
WenBin Liu, Lifang Hu, RuoXuan Zhao, ZhiYong Hou, JinYu Tian   +4 more
wiley   +1 more source