Results 171 to 180 of about 363,862 (308)
British Journal of Pharmacology, EarlyView., 2023 Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi +6 more
wiley +1 more source
Gαq signalling from endosomes: A new conundrum
British Journal of Pharmacology, EarlyView., 2023 Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley +1 more source
Effect of Background Synaptic Activity on Excitatory-Postsynaptic Potential-Spike Coupling
, 2017 Neurons receive large amount of synaptic inputs in vivo, which may impact the coupling between EPSPs and spikes. We mimicked the in vivo synaptic activity of the cell with the dynamic clamp system. We recorded from pyramidal cells in neocortical slices in vitro to investigate how timing and probability of spike generation in response to an EPSP is ...
openaire +2 more sources
Intrinsic brain network stability during kainic acid‐induced epileptogenesis
Epilepsia Open, EarlyView.Abstract Objective Altered intrinsic brain networks have been revealed in patients with epilepsy and are strongly associated with network reorganization in the latent period. However, the development and reliability of intrinsic brain networks in the early period of epileptogenesis are not well understood.
Nastaran Jafari +8 more
wiley +1 more source
Exploration, EarlyView.Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang +4 more
wiley +1 more source
Flexible ionic‐gel synapse devices and their applications in neuromorphic system
FlexMat, EarlyView.To promote the development of wearable neuromorphic systems, flexible ionic‐gel synapses (IGSs) have attracted much attention in recent years due to their significant mechanical robustness, high ionic conductivity and good biocompatibility. Here, we present a review on IGS devices and the recent progress in flexible IGS‐based neuromorphic systems ...
Fengchang Huang +3 more
wiley +1 more source
Clinical Genetics, Volume 103, Issue 1, Page 103-108, January 2023., 2023 We describe here the case of a 36‐year‐old female with a de novo pathogenic variant in KCNJ6 (NM_002240.5: c.460G>T; p.(Gly154Cys)) presenting with mild intellectual disability, subtle dysmorphic features, obsessive–compulsive disorder, and an exaggerated startle response, thereby expanding the spectrum of KCNJ6‐related disorders to milder phenotypes ...
Vesna Marija van Midden +4 more
wiley +1 more source
Heteroepitaxy of ε‐Ga2O3 thin film for artificial synaptic device
InfoScience, EarlyView.The ε phase Ga2O3 thin film was deposited on 2‐inch commercial c‐sapphire substrate using a MOCVD technique. Based on the ε‐Ga2O3 metal‐semiconductor‐metal structure photodetector, classical biological synaptic behaviors such as excitatory postsynaptic current, short term memory, long term memory, pair pulse facilitation, and “learning‐forgetting ...
Longxing Su +3 more
wiley +1 more source
European Journal of Neuroscience, Volume 56, Issue 12, Page 6141-6161, December 2022., 2022 Chemical synapses are tiny and overcrowded environments enriched with thousands of protein species. Many efforts have been devoted to developing sensors and actuators able to evaluate and control synaptic communication. Most of these recent tools are based on the engineering of one or more specific synaptic proteins used to target active moieties to ...
Jacopo Lamanna +3 more
wiley +1 more source
Archives of Medical Science, 2005 The Enteric Nervous System (ENS) plays a key role in regulating the function of the gastrointestinal tract. The knowledge about the function of neurons is based on experiments using the intracellular recording method.
Michał Ceregrzyn +2 more
doaj