Results 41 to 50 of about 174,824 (351)

Aberrant excitatory rewiring of layer V pyramidal neurons early after neocortical trauma

Neurobiology of Disease, 2016
Lesioned neuronal circuits form new functional connections after a traumatic brain injury (TBI). In humans and animal models, aberrant excitatory connections that form after TBI may contribute to the pathogenesis of post-traumatic epilepsy.
D. Koji Takahashi, Feng Gu, Isabel Parada, Shri Vyas, David A. Prince   +4 more
doaj   +1 more source

Underlying mechanisms of long-term potentiation during the inhibition of the cannabinoid CB1 and GABAB receptors in the dentate gyrus of hippocampus

BMC Neuroscience, 2023
Background The release of various neurotransmitters and thereby the excitability of neuronal circuits are regulated by the endocannabinoid system in an activity-dependent manner. Hippocampal long-term potentiation (LTP) is augmented in cannabinoid type 1
Masoumeh Nazari, Seyed Asaad Karimi, Somayeh Komaki, Masoumeh Kourosh Arami, Alireza Komaki   +4 more
doaj   +1 more source

Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus

Molecular Brain, 2020
The receptor deleted in colorectal cancer (DCC) and its ligand netrin-1 are essential for axon guidance during development and are expressed by neurons in the mature brain.
Stephen D. Glasgow, Edwin W. Wong, Greta Thompson-Steckel, Nathalie Marcal, Philippe Séguéla, Edward S. Ruthazer, Timothy E. Kennedy   +6 more
doaj   +1 more source

Functional maps of neocortical local circuitry

Frontiers in Neuroscience, 2007
This review aims to summarize data obtained with different techniques to provide a functional map of the local circuit connections made by neocortical neurones, a reference for those interested in cortical circuitry and the numerical information required
Alex M Thomson, Christophe Lamy
doaj   +1 more source

Disruption of KCC2 in Parvalbumin-Positive Interneurons Is Associated With a Decreased Seizure Threshold and a Progressive Loss of Parvalbumin-Positive Interneurons

Frontiers in Molecular Neuroscience, 2022
GABAA receptors are ligand-gated ion channels, which are predominantly permeable for chloride. The neuronal K-Cl cotransporter KCC2 lowers the intraneuronal chloride concentration and thus plays an important role for GABA signaling. KCC2 loss-of-function
Tanja Herrmann, Melanie Gerth, Ralf Dittmann, Daniel Pensold, Martin Ungelenk, Lutz Liebmann, Christian A. Hübner   +6 more
doaj   +1 more source

Neuromodulation of Chemical Synaptic Transmission Driven by THz Photons

Research, 2022
Postsynaptic currents of chemical synapse are modulated by multitudinous neurotransmitters, such as acetylcholine, dopamine, glutamate, and γ-aminobutyric acid, many of which have been used in the treatment of neurological diseases.
Xiaoxuan Tan, Yuan Zhong, Ruijie Li, Chao Chang   +3 more
doaj   +1 more source

Inhibitory or excitatory? Optogenetic interrogation of the functional roles of GABAergic interneurons in epileptogenesis

Journal of Biomedical Science, 2017
Alteration in the excitatory/inhibitory neuronal balance is believed to be the underlying mechanism of epileptogenesis. Based on this theory, GABAergic interneurons are regarded as the primary inhibitory neurons, whose failure of action permits ...
Hui Ye, Stephanie Kaszuba
doaj   +1 more source

Prolonged prophylactic effects of gabapentin on status epilepticus-induced neocortical injury

Neurobiology of Disease, 2020
Long-term consequences of status epilepticus (SE) occur in a significant proportion of those who survive the acute episode. We developed an in vivo model of acute focal neocortical SE (FSE) to study long-term effects on local cortical structure and ...
Maria-Belen Perez-Ramirez, Feng Gu, David A. Prince   +2 more
doaj   +1 more source

Calcium channels controlling acetylcholine release from preganglionic nerve terminals in rat autonomic ganglia [PDF]

, 1999
Little is known about the nature of the calcium channels controlling neurotransmitter release from preganglionic parasympathetic nerve fibres. In the present study, the effects of selective calcium channel antagonists and amiloride were investigated on ...
A.B Smith, Boot, Bowersox, Brock, Brock, D.J Adams, De Luca, Dunlap, Gonzalez-Burgos, Hong, Ireland, L Motin, Lavidis, Lin, Lundy, McDonough, Meir, N.A Lavidis, Randall, Randall, Rogers, Seabrook, Smith, Smith, Smith, Smith, Snider, Tabatabai, Tang, Todorovic, Warren, Waterman, Wright, Wu   +33 more
core   +1 more source

Accumulation of Dense Core Vesicles in Hippocampal Synapses Following Chronic Inactivity. [PDF]

, 2018
The morphology and function of neuronal synapses are regulated by neural activity, as manifested in activity-dependent synapse maturation and various forms of synaptic plasticity.
Bi, Guo-Qiang, Lau, Pak-Ming, Liu, Yun-Tao, Tao, Chang-Lu, Zhou, Z Hong   +4 more
core   +2 more sources