Results 41 to 50 of about 368,740 (208)
The Journal of Physiology, 1990 1. The effects of acetylcholine (ACh) on excitatory postsynaptic potentials (EPSPs) evoked by stimulating Schaffer‐commissural afferents and on ionophoretically applied L‐glutamate ligands, were investigated in CA1 neurones of hippocampal slices using current‐ and voltage‐clamp techniques. 2.
Markram, H., Segal, M.
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Biologically plausible solutions for spiking networks with efficient coding [PDF]
arXiv, 2022 Understanding how the dynamics of neural networks is shaped by the computations they perform is a fundamental question in neuroscience. Recently, the framework of efficient coding proposed a theory of how spiking neural networks can compute low-dimensional stimulus signals with high efficiency.
arxiv
Anterograde Activin signaling regulates postsynaptic membrane potential and GluRIIA/B abundance at the Drosophila neuromuscular junction. [PDF]
PLoS ONE, 2014 Members of the TGF-β superfamily play numerous roles in nervous system development and function. In Drosophila, retrograde BMP signaling at the neuromuscular junction (NMJ) is required presynaptically for proper synapse growth and neurotransmitter ...
Myung-Jun Kim, Michael B O'Connor
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γ-Hydroxybutyrate inhibits excitatory postsynaptic potentials in rat hippocampal slices
European Journal of Pharmacology, 1999 Gamma-Hydroxybutyrate (GHB) has been shown to mimic different central actions of ethanol, to suppress alcohol withdrawal syndrome, and to reduce alcohol consumption both in rats and in humans. The aim of the present study was to determine if GHB shared with alcohol the ability to inhibit glutamate action at both NMDA and AMPA/kainate receptors.
BERTON, FULVIA +6 more
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Active summation of excitatory postsynaptic potentials in hippocampal CA3 pyramidal neurons [PDF]
Proceedings of the National Academy of Sciences, 1998 The manner in which the thousands of synaptic inputs received by a pyramidal neuron are summed is critical both to our understanding of the computations that may be performed by single neurons and of the codes used by neurons to transmit information. Recent work on pyramidal cell dendrites has shown that subthreshold synaptic inputs are modulated by ...
Nathaniel N. Urban, German Barrionuevo
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Scientific Reports, 2022 The transient receptor potential melastatin 4 (TRPM4) channel contributes to disease severity in the murine experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis and to neuronal cell death in models of excitotoxicity and traumatic ...
Brenna C. Fearey +7 more
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Frontiers in Neuroscience, 2021 Loss of function mutations in PARK6, the gene that encodes the protein PTEN-induced kinase 1 (PINK1), cause autosomal recessive familial Parkinson’s disease (PD).
Adeel A. Memon +17 more
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Suppression of hypersynchronous network activity in cultured cortical neurons using an ultrasoft silicone scaffold [PDF]
Soft Matter 16 (2020) 3195-3202, 2019 The spontaneous activity pattern of cortical neurons in dissociated culture is characterized by burst firing that is highly synchronized among a wide population of cells. The degree of synchrony, however, is excessively higher than that in cortical tissues.
arxiv +1 more source
Probabilistic Fluorescence-Based Synapse Detection [PDF]
, 2016 Brain function results from communication between neurons connected by complex synaptic networks. Synapses are themselves highly complex and diverse signaling machines, containing protein products of hundreds of different genes, some in hundreds of ...
Aguerrebere, Cecilia +7 more
core +4 more sources
Lithium ameliorates autistic-like behaviors induced by neonatal isolation in rats
Frontiers in Behavioral Neuroscience, 2014 Neonatal isolation is a widely accepted model to study the long-term behavioral changes produced by the early life events. However, it remains unknown whether neonatal isolation can induce autistic-like behaviors, and if so, whether pharmacological ...
Xiaoyan eWu +17 more
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