Results 41 to 50 of about 179,338 (253)

Disruption of KCC2 in Parvalbumin-Positive Interneurons Is Associated With a Decreased Seizure Threshold and a Progressive Loss of Parvalbumin-Positive Interneurons

Frontiers in Molecular Neuroscience, 2022
GABAA receptors are ligand-gated ion channels, which are predominantly permeable for chloride. The neuronal K-Cl cotransporter KCC2 lowers the intraneuronal chloride concentration and thus plays an important role for GABA signaling. KCC2 loss-of-function
Tanja Herrmann, Melanie Gerth, Ralf Dittmann, Daniel Pensold, Martin Ungelenk, Lutz Liebmann, Christian A. Hübner   +6 more
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Loss of FKBP5 Affects Neuron Synaptic Plasticity: An Electrophysiology Insight [PDF]

, 2019
FKBP5 (FKBP51) is a glucocorticoid receptor (GR) binding protein, which acts as a co-chaperone of heat shock protein 90 (HSP90) and negatively regulates GR.
Deng, Ran, Dou, Longyu, Liang, Tiebing, Liu, Ming, Qiu, Bin, Ren, Wei, Shou, Weinian, Stewart, Robert B., Wang, Chao, Wang, Jun, Williams, Kent E., Xie, Zhongwen, Xu, Yuxue, Yong, Weidong, Zhao, Zhenwen   +14 more
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Inhibitory or excitatory? Optogenetic interrogation of the functional roles of GABAergic interneurons in epileptogenesis

Journal of Biomedical Science, 2017
Alteration in the excitatory/inhibitory neuronal balance is believed to be the underlying mechanism of epileptogenesis. Based on this theory, GABAergic interneurons are regarded as the primary inhibitory neurons, whose failure of action permits ...
Hui Ye, Stephanie Kaszuba
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Prolonged prophylactic effects of gabapentin on status epilepticus-induced neocortical injury

Neurobiology of Disease, 2020
Long-term consequences of status epilepticus (SE) occur in a significant proportion of those who survive the acute episode. We developed an in vivo model of acute focal neocortical SE (FSE) to study long-term effects on local cortical structure and ...
Maria-Belen Perez-Ramirez, Feng Gu, David A. Prince   +2 more
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Accumulation of Dense Core Vesicles in Hippocampal Synapses Following Chronic Inactivity. [PDF]

, 2018
The morphology and function of neuronal synapses are regulated by neural activity, as manifested in activity-dependent synapse maturation and various forms of synaptic plasticity.
Bi, Guo-Qiang, Lau, Pak-Ming, Liu, Yun-Tao, Tao, Chang-Lu, Zhou, Z Hong   +4 more
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Neuromodulation of Chemical Synaptic Transmission Driven by THz Photons

Research, 2022
Postsynaptic currents of chemical synapse are modulated by multitudinous neurotransmitters, such as acetylcholine, dopamine, glutamate, and γ-aminobutyric acid, many of which have been used in the treatment of neurological diseases.
Xiaoxuan Tan, Yuan Zhong, Ruijie Li, Chao Chang   +3 more
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Rapid surface accumulation of NMDA receptors increases glutamatergic excitation during status epilepticus

Neurobiology of Disease, 2013
After 1 h of lithium-pilocarpine status epilepticus (SE), immunocytochemical labeling of NMDA receptor NR1 subunits reveals relocation of subunits from the interior to the cell surface of dentate gyrus granule cells and CA3 pyramidal cells ...
David E. Naylor, Hantao Liu, Jerome Niquet, Claude G. Wasterlain   +3 more
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Dynamical principles in neuroscience [PDF]

, 2006
Dynamical modeling of neural systems and brain functions has a history of success over the last half century. This includes, for example, the explanation and prediction of some features of neural rhythmic behaviors.
Abarbanel, H. D. I., Abarbanel, H. D. I., Abeles, M., Abeles, M., Adrian, E. D., Allen I. Selverston, Amit, D., Amit, D. J., Andronov, A., Andronov, A., Andronov, A. A., Arbib, M. A., Arnold, V., Ashby, W. R., Baird, B., Bartos, M., Bartos, M., Bi, G., Bliss, T. V., Bondarenko, V., Borda, J. C., Canavier, C., Chay, T., Chklovskii, D. B., Cohen, M. A., Crevier, D., Cymbalyuk, G., de Nó, R. L., deCharms, R., Diwadkar, V. A., Duda, R., Elson, R. C., Fano, R. M., Fatt, P., Freeman, W., Freeman, W., Fuhrmann, G., Gallager, R. G., Gavrilov, N., Gerstner, W., Glass, L., Goroff, D., Grossberg, S., Guckenheimer, J., Hatsopoulos, N., Hebb, R., Henry D. I. Abarbanel, Hodgkin, A. L., Hopfield, J., Ichinohe, N., Ince, D., Izhikevich, E., Jones, S. R., Kandel, E. R., Kaplan, D., Katz, B., Kim, U., Kimpo, R. R., Koch, C., Konishi, M., Kuramoto, Y., Kuznetsov, Y., Landau, L. D., Lapicque, L., Lashley, K., Levi, R., Lindner, B., Lotka, A. J., Malkov, V., Maravall, M., Marder, E., Mikhail I. Rabinovich, Nicholls, J. G., Nowotny, T., Oscarsson, O., Ott, E., O’Reilly, R., Pablo Varona, Panchin, Y., Pikovsky, A., Poincaré, A., Poincaré, H., Prinz, A., Prinz, A. A., Rabinovich, M., Ramirez, J., Reinagel, P., Rosenblatt, F., Rowe, D., Saari, G., Segundo, J. P., Segundo, J. P., Senseman, D. M., Seung, H. S., Shadlen, M. N., Shepherd, G., Simmers A. J., Singer, W., Stein, S. G., Strogatz, S. H., Szekely, G., Szücs, A., Szücs, A., Szücs, A., Tsuda, I., Turrigiano, G. G., Varona, P., Volterra, V., Wang, X.-J., Wilson, H. R., Zhigulin, V. P.   +110 more
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Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn [PDF]

, 2017
The spinal dorsal horn receives input from primary afferent axons, which terminate in a modality-specific fashion in different laminae. The incoming somatosensory information is processed through complex synaptic circuits involving excitatory and ...
Todd, Andrew J.
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Anterograde Activin signaling regulates postsynaptic membrane potential and GluRIIA/B abundance at the Drosophila neuromuscular junction. [PDF]

PLoS ONE, 2014
Members of the TGF-β superfamily play numerous roles in nervous system development and function. In Drosophila, retrograde BMP signaling at the neuromuscular junction (NMJ) is required presynaptically for proper synapse growth and neurotransmitter ...
Myung-Jun Kim, Michael B O'Connor
doaj   +1 more source