Results 41 to 50 of about 139,452 (278)

Lithium ameliorates autistic-like behaviors induced by neonatal isolation in rats

Frontiers in Behavioral Neuroscience, 2014
Neonatal isolation is a widely accepted model to study the long-term behavioral changes produced by the early life events. However, it remains unknown whether neonatal isolation can induce autistic-like behaviors, and if so, whether pharmacological ...
Xiaoyan eWu, Xiaoyan eWu, Yanrui eBai, Yanrui eBai, Tao eTan, Tao eTan, Hongjie eLi, Hongjie eLi, Shuting eXia, Xinxia eChang, Zikai eZhou, Weihui eZhou, Weihui eZhou, Tingyu eLi, Tingyu eLi, Yu Tian eWang, Zhifang eDong, Zhifang eDong   +17 more
doaj   +1 more source

Basal Synaptic Transmission and Long-Term Plasticity at CA3-CA1 Synapses Are Unaffected in Young Adult PINK1-Deficient Rats

Frontiers in Neuroscience, 2021
Loss of function mutations in PARK6, the gene that encodes the protein PTEN-induced kinase 1 (PINK1), cause autosomal recessive familial Parkinson’s disease (PD).
Adeel A. Memon, Adeel A. Memon, Adeel A. Memon, Adeel A. Memon, Micah E. Bagley, Rose B. Creed, Rose B. Creed, Rose B. Creed, Amy W. Amara, Amy W. Amara, Amy W. Amara, Matthew S. Goldberg, Matthew S. Goldberg, Matthew S. Goldberg, Lori L. McMahon, Lori L. McMahon, Lori L. McMahon, Lori L. McMahon   +17 more
doaj   +1 more source

Equilibrium Properties of Temporally Asymmetric Hebbian Plasticity [PDF]

, 2000
A theory of temporally asymmetric Hebb (TAH) rules which depress or potentiate synapses depending upon whether the postsynaptic cell fires before or after the presynaptic one is presented.
C. W. Eurich, Daniel D. Lee, G. Q. Bi, H. Markram, H. Sompolinsky, Jonathan Rubin, L. F. Abbott, M. C. W. van Rossum, R. Kempter, R. P. N. Rao, W. M. Kistler   +10 more
core   +4 more sources

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

Glutamatergic transmission in the central nucleus of the amygdala is selectively altered in Marchigian Sardinian alcohol-preferring rats: Alcohol and CRF effects [PDF]

, 2015
The CRF system of the central nucleus of the amygdala (CeA) is important for the processing of anxiety, stress, and effects of acute and chronic ethanol.
CICCOCIOPPO, Roberto, Heilig, Markus, Herman, Melissa A, Kirson, Dean, Luu, George, Oleata, Christopher S, Roberto, Marisa, Varodayan, Florence P   +7 more
core   +1 more source

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4. [PDF]

, 2014
Lrp4, the muscle receptor for neuronal Agrin, is expressed in the hippocampus and areas involved in cognition. The function of Lrp4 in the brain, however, is unknown, as Lrp4-/- mice fail to form neuromuscular synapses and die at birth.
Burden, Steven J, Froemke, Robert C, Gomez, Andrea M   +2 more
core   +1 more source

Mimicking Synaptic Plasticity: Optoionic MoS2 Memory Powered by Biopolymer Hydrogels as a Dynamic Cations Reservoir

Advanced Functional Materials, EarlyView.
Janus (MoS2) transistors functionalized with sodium alginate (SA) and poly(vinylidene fluoride‐co‐trifluoroethylene) [P(VDF‐TrFE)] exhibit persistent photo‐induced ionic gating, driven by dynamic cation migration at the hybrid interface. This ionic mechanism enables finely tunable photoconductivity and emulates key synaptic plasticity behaviors ...
Yeonsu Jeong, Pietro Tordi, Adrián Tamayo, Bin Han, Massimo Bonini, Paolo Samorì   +5 more
wiley   +1 more source

Enhanced Switching Performance in Single‐Crystalline PbTiO3 Ferroelectric Memristors for Replicating Synaptic Plasticity

Advanced Functional Materials, EarlyView.
This study demonstrated single‐crystalline PbTiO3‐based memristors with atomically sharp interfaces, well‐ordered lattices, and minimal lattice mismatch. The devices exhibited an ON/OFF ratio exceeding 105, high stability, and rich resistance‐state modulation.
Haining Li, Zhiqiang Liao, Risa Kataoka, Md Sarker Shamim, Takeshi Kijima, Hiroyasu Yamahara, Hitoshi Tabata, Munetoshi Seki   +7 more
wiley   +1 more source

Mild Traumatic Brain Injury Evokes Pyramidal Neuron Axon Initial Segment Plasticity and Diffuse Presynaptic Inhibitory Terminal Loss

Frontiers in Cellular Neuroscience, 2017
The axon initial segment (AIS) is the site of action potential (AP) initiation, thus a crucial regulator of neuronal activity. In excitatory pyramidal neurons, the high density of voltage-gated sodium channels (NaV1.6) at the distal AIS regulates AP ...
Michal Vascak, Jianli Sun, Matthew Baer, Kimberle M. Jacobs, John T. Povlishock   +4 more
doaj   +1 more source