Results 201 to 210 of about 82,251 (326)

Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing

, 2011
Shahana S. Mahajan, K.H. Thai, Ken Chen, Edward B. Ziff   +3 more
openalex   +2 more sources

Pigment Epithelium‐Derived Factor Deficiency Impairs Hippocampal Glutamate Homeostasis and Cognitive Function by Downregulating Astrocytic GLT‐1

Advanced Science, Volume 12, Issue 45, December 4, 2025.
The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi, Qi‐Long Tang, Jin‐Hong Wang, Yan‐Lan Long, Sai‐Feng Zhao, Zhen Zhao, Wan‐Ting Xie, Zi‐Ming Li, Hao‐Ming Lu, Tian‐Xiao Gao, Zhen‐Zhen Fang, Ti Zhou, Bo‐Xing Li, Xia Yang, Guo‐Quan Gao, Wei‐Wei Qi   +15 more
wiley   +1 more source

mGluR5 as a Potential Orchestrator of Astrocyte Interactions in Neurological Disorders. [PDF]

Neural Plast
Kim J, Lee J, Song H, Koo JW, Kang S.
europepmc   +1 more source

Emerging Biosensor Technologies for Stroke Biomarker Detection: A Comprehensive Overview

Analytical Science Advances, Volume 6, Issue 2, December 2025.
ABSTRACT Stroke remains a leading cause of morbidity and mortality worldwide, necessitating the development of rapid and reliable diagnostic tools for early detection and management. This manuscript presents an overview of innovative biosensors designed for the detection of key stroke biomarkers, including N‐terminal pro B‐type natriuretic peptide (NT ...
Ghazal Koohkansaadi, Arash Mohagheghi, Ahmad Mobed, Saeid Charsouei   +3 more
wiley   +1 more source

Parechovirus-3 infection disrupts immunometabolism and leads to glutamate excitotoxicity in neural organoids. [PDF]

Cell Mol Life Sci
Capendale PE, Ambikan AT, García-Rodríguez I, de Sá RV, Pajkrt D, Wolthers KC, Neogi U, Sridhar A.   +7 more
europepmc   +1 more source

The Role and Therapeutic Potential of the cGAS‐STING Signaling Pathway in Alzheimer's Disease

Brain and Behavior, Volume 15, Issue 12, December 2025.
This work reveals the relationship between the cGAS‐STING signaling pathway and the pathological mechanisms of Alzheimer's disease.The role of the cGAS‐STING signaling pathway in AD pathology. AD leads to the production of neutrophil extracellular traps (NETs), endoplasmic reticulum (ER) stress, and the release of mitochondrial DNA (mtDNA) and nuclear ...
Xue Li, Wei Gao, Qiuyan Ye, Honglin Li
wiley   +1 more source

Synaptic Pathology in Traumatic Brain Injury and Therapeutic Insights. [PDF]

Int J Mol Sci
Nuthalapati P, Holmes SE, Altalib HH, Fesharaki-Zadeh A.   +3 more
europepmc   +1 more source

CaMKII phosphorylates collapsin response mediator protein 2 and modulates axonal damage during glutamate excitotoxicity

, 2009
Sheng‐Tao Hou, Susan X. Jiang, Amy Aylsworth, Graeme Ferguson, Jacqueline Slinn, Houwen Hu, Thomas Leung, Joachim Kappler, Kozo Kaibuchi   +8 more
openalex   +2 more sources

Iron enhances reactive oxygen species generation and initiates neutrophil extracellular traps formation on the endothelium to exacerbate stroke

Journal of Cell Communication and Signaling, Volume 19, Issue 4, December 2025.
Under hypoxic conditions, iron from red blood cells and injured tissues is taken up by endothelial cells. During reoxygenation, this iron is exported via Fpn1, promoting NETs formation by enhancing ROS production through the Fenton reaction, ultimately exacerbating cerebral injury.
Weijian Fan, Zebin Fang, Yuxiang Weng, Tianxiang Zhan, Kaiyuan Huang, Jianwei Pan, Renya Zhan   +6 more
wiley   +1 more source

Losing the Filter: How Kynurenine Pathway Dysregulation Impairs Habituation. [PDF]

Cells
de la Flor MA, O'Connor JC.
europepmc   +1 more source