Results 211 to 220 of about 83,508 (337)

Decreasing Levels of the cdk5 Activators, p25 and p35, Reduces Excitotoxicity in Striatal Neurons

, 2012
Kevin H. J. Park, Ge Lu, Jing Fan, Lynn A. Raymond, Blair R. Leavitt   +4 more
openalex   +2 more sources

A complex network perspective on brain disease

Biological Reviews, Volume 101, Issue 1, Page 364-399, February 2026.
ABSTRACT If brain anatomy and dynamics have a complex network structure as it has become standard to posit, it is reasonable to assume that such a structure should play a key role not only in brain function but also in brain dysfunction. However, exactly how network structure is implicated in brain damage and whether at least some pathologies can be ...
David Papo, Javier M. Buldú
wiley   +1 more source

Astrocyte Regulation of Spinal Circuit Function

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Spinal cord astrocytes exist as an additional component of the computational framework that governs both sensory perceptions and motor outputs (left). By integrating local synaptic activity together with signals that reflect whole‐body state (e.g., neuromodulators, immune signals, and vascular signals) into defined input states (Sn), astrocytes adapt ...
Mary Kaye Duff, Min Jun Li, Axel Nimmerjahn   +2 more
wiley   +1 more source

Exploiting glial cell functions for neurodegeneration therapy. [PDF]

Neuroprotection
Olajide TS.
europepmc   +1 more source

Inhibitory GABAergic Neuron Loss due to Oxidative Damage During Ex Vivo Acute Brain Slice Preparation Influences Genesis and Dynamics of Epileptiform Activity

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Ex vivo brain slice preparation is a popular technique in neuroscience research with many variations in preparation method. We compared two popular variations in brain slice preparation and found that the choice of brain slice preparation technique significantly affects the viability of neuronal preparation.
Felix Chan, Anupam Hazra, Ashan Jayasekera, Katherine Huang, Shuna Whyte, Leolie Telford‐Cooke, Kamilah Lakhani, Xiaomeng Li, Rebecca Shields, Angeline Kosim, Darwin Su, Carol Murray, Mark O. Cunningham   +12 more
wiley   +1 more source

Incretin Mimetics as Potential Therapeutics for Concussion and Traumatic Brain Injury: A Narrative Review. [PDF]

Int J Mol Sci
Sipos S, Jerkic M, Rotstein OD, Schweizer TA.   +3 more
europepmc   +1 more source

Targeting the somatostatin receptors as a therapeutic approach for the preservation and protection of the mammalian cochlea from excitotoxicity [PDF]

, 2013
Vesna Radojevic, Yves Brand, Soledad Levano, Cristian Setz, Daniel Bodmer   +4 more
openalex   +1 more source

Pleiotrophin/Midkine Pathway Is Dysregulated in a TDP‐43A315T Mouse Model of Amyotrophic Lateral Sclerosis (ALS)

Neuropathology, Volume 46, Issue 1, February 2026.
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) characterized by progressive degeneration of both upper and lower motor neurons, along with skeletal muscles innervated by them. The identification of key molecules involved in disease pathology remains crucial for ALS, as no curative treatment is currently available ...
Paloma Martínez‐Alesón, Cristina Benito‐Casado, Carmen María Fernández‐Martos, María José Polanco Mora   +3 more
wiley   +1 more source

Strenuous Exercise Alters Brain Creatine and Glutamate/Glutamine (Glx) in Humans: Evidence From Dynamic 1H‐MRS and 1H‐MRSI

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Strenuous exercise induces transient, region‐specific neurochemical changes in the human brain. Dynamic proton magnetic resonance spectroscopy (1H‐MRS) and spectroscopic imaging (1H‐MRSI) revealed reductions in total creatine (tCr), and elevations in glutamate/glutamine (Glx), and lactate (Lac) in frontal and parietal brain regions.
Jedd Pratt, Antonia Kaiser, Libby Henthorn, Oliver Mundell, Elise From, Aneurin J. Kennerley, Craig Sale   +6 more
wiley   +1 more source

Natural LXRβ agonist stigmasterol confers protection against excitotoxicity after hypoxia- reoxygenation (H/R) injury via regulation of mitophagy in primary hippocampal neurons [PDF]

, 2019
Md. Nazmul Haque, Md. Abdul Hannan, Raju Dash, Il Soo Moon   +3 more
openalex   +1 more source