Results 211 to 220 of about 82,251 (326)

Alpinetin Targets Mitophagy Pathways to Mitigate Parkinson's Disease Progression

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
Combining network pharmacology, molecular docking, and in vivo studies, we demonstrate that Alpinetin exerts neuroprotective effects in PD by ameliorating mitophagy dysfunction and preserving dopaminergic synaptic integrity. ABSTRACT Aims Parkinson's disease (PD) is a complex neurodegenerative disorder lacking disease‐modifying therapies.
Zilu Shen, Xuesong Shan, Shenglan Zhang, Dan Huang, Haijun Hu, Yonglin Liang, Hong Zhu, Lieliang Zhang, Yayu Chen   +8 more
wiley   +1 more source

Scutellarin Protects Retinal Ganglion Cells in Glaucoma by Targeting the Hsp90aa1-MAPK Pathway to Inhibit Apoptosis. [PDF]

Invest Ophthalmol Vis Sci
Su JZ, Wang J, Gao ZL, Ding L, Xia XB.
europepmc   +1 more source

Characterization of Neuroprotection from Excitotoxicity by Moderate and Profound Hypothermia in Cultured Cortical Neurons Unmasks a Temperature-Insensitive Component of Glutamate Neurotoxicity [PDF]

, 1998
Michael Tymianski, Rita Sattler, Joseph M. Zabramski, Robert F. Spetzler   +3 more
openalex   +1 more source

DL‐3‐n‐Butylphthalide Protects Mitochondria Against Ischemia/Hypoxia Damage via Suppressing GCN5L1‐Mediated Drp1 Acetylation in Neurons and Mouse Brains

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
This study provides a novel insight into the molecular mechanism whereby NBP protects mitochondria against ischemia/hypoxia damage, offering a promising drug for mitochondria‐targeting therapeutics for ischemic stroke. ABSTRACT Background Mitochondrial dysfunction is an initial event of the cascade reactions triggered by ischemic stroke, contributing ...
Haitao Zhang, Ning Zhang, Xiaotong Yang, Jiejie Zhang, Xiaoli Ge, Lei Wang, Shan Wang, Ya Wen   +7 more
wiley   +1 more source

Reduction of the Ca²⁺ permeability of ligand-gated ion channels as a strategy against excitotoxicity. [PDF]

Front Cell Neurosci
D'Andrea T, Fucile S.
europepmc   +1 more source

Carbogen Inhalation Therapy for Epileptic Seizures: Mechanisms, Evidence, and Future Directions

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
Carbogen, a low‐dose CO2/O2 mixture, modulates brain pH to suppress hyperexcitability through rapid and reversible pH‐dependent mechanisms distinct from conventional antiseizure medications (ASMs). Preclinical and small clinical studies show efficacy in focal and absence seizures, whereas variable responses in other types highlight the need for ...
Li Wang, Yue Liu, Wenwen Ding, Meng Yang, Qing Liu, Fuqiang Xu   +5 more
wiley   +1 more source

Protective effects of glucosamine-kynurenic acid after compression-induced spinal cord injury in the rat

Open Life Sciences, 2012
Korimová Andrea, Cížková Dáša, Toldi Jozsef, Vécsei László, Vanický Ivo   +4 more
doaj   +1 more source

Molecular mechanisms of excitotoxicity and their relevance to the pathogenesis of neurodegenerative diseases-an update. [PDF]

Acta Pharmacol Sin
Wu WL, Gong XX, Qin ZH, Wang Y.
europepmc   +1 more source

Cellular Communication Networks Mediated by Microglia in Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
After ischemic stroke, microglia serve as central regulators within the neuroimmune network, engaging in dynamic crosstalk with neurons, astrocytes, vascular endothelial cells, and peripheral immune cells. By releasing cytokines, chemokines, extracellular vesicles, and transmitting mechanical signals, activated microglia coordinate inflammatory ...
Feiyu Ma, Yi Bai, Na Li, Xiangyu Cai, Ruicong Xu, Xiang Cao   +5 more
wiley   +1 more source

Biochanin A prevents neurodegeneration and oxidative stress in a kainic acid model of epilepsy by activating the PI3K/Akt/Nrf2 signaling pathway. [PDF]

Sci Rep
Kongsui R, Promsrisuk T, Chanmanee T, Klimaschewski L, Jamsuwan S, Sriraksa N, Jittiwat J, Thongrong S.   +7 more
europepmc   +1 more source