Results 71 to 80 of about 15,412 (264)

Existential boredom as a phenomenon of human social existence

Sovremennye Issledovaniâ Socialʹnyh Problem
Background. Until now, science lacks a holistic philosophical understanding of the phenomenon of existential boredom and has not developed an attitude towards it, although it is recognized in the scientific community.
Svetlana M. Maltseva, Polina O. Ivanova, Olga P. Kashina   +2 more
doaj   +1 more source

The practice of dealing with existential questions in long-term elderly care

International Journal of Qualitative Studies on Health & Well-Being, 2018
Purpose: Existential questions concerning life and death or meaning in life are very salient for many older people receiving long-term care. However, little is known about how long-term care organizations deal with existential issues.
Wander van der Vaart, Rosanna van Oudenaarden   +1 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The Existential Vacuum and Its Relationship to Pessimism and Optimism among Undergraduate Students

Islamic Guidance and Counseling Journal
University students may confront an existential vacuum, characterized by a loss of life's meaning resulting from personal crises, socio-political shifts, and health transformations. These challenges, which some young individuals may struggle to adapt to,
Mohammed H. Abood, Thaer A. Ghbari
doaj   +1 more source

Lost in an unknown terrain: a phenomenological contribution to the understanding of existential concerns as experienced by young women in Sweden

International Journal of Qualitative Studies on Health & Well-Being, 2019
Purpose: The aim of this study is to describe young women’s (16–25 years old) experiences of living with existential concerns for which they have sought support from healthcare professionals, teachers, family, or friends, among others.
Maria Lundvall, Elisabeth Lindberg, Ulrica Hörberg, Gunilla Carlsson, Lina Palmér   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Living in Limbo: Existential Concerns Among Greek Young Adults

Youth
Existential concerns are particularly salient during emerging adulthood—a period marked by identity exploration, uncertainty, and developmental transitions. This qualitative study explores the existential anxieties of Greek young adults within the unique
Dimitrios Pavlidis, Panagiota Tragantzopoulou   +1 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source