Results 21 to 30 of about 167,613 (264)

Intracellular Mechanistic Understanding of 2D MoS2 Nanosheets for Anti-Exocytosis-Enhanced Synergistic Cancer Therapy.

ACS Nano, 2018
Emerging two-dimensional (2D) nanomaterials, such as transition-metal dichalcogenide (TMD) nanosheets (NSs), have shown tremendous potential for use in a wide variety of fields including cancer nanomedicine.
Xianbing Zhu, X. Ji, Na Kong, Yunhan Chen, M. Mahmoudi, Xiaoding Xu, Li Ding, Wei Tao, Ting Cai, Yujing Li, T. Gan, Austin Barrett, Z. Bharwani, Hongbo Chen, O. Farokhzad   +14 more
semanticscholar   +1 more source

Dual Effect of Rosuvastatin on Glucose Homeostasis Through Improved Insulin Sensitivity and Reduced Insulin Secretion

EBioMedicine, 2016
Statins are beneficial in the treatment of cardiovascular disease (CVD), but these lipid-lowering drugs are associated with increased incidence of new on-set diabetes.
Vishal A. Salunkhe, Inês G. Mollet, Jones K. Ofori, Helena A. Malm, Jonathan L.S. Esguerra, Thomas M. Reinbothe, Karin G. Stenkula, Anna Wendt, Lena Eliasson, Jenny Vikman   +9 more
doaj   +1 more source

Effects of the surface charge of polyamidoamine dendrimers on cellular exocytosis and the exocytosis mechanism in multidrug-resistant breast cancer cells

Journal of Nanobiotechnology, 2021
Background Polyamidoamine (PAMAM) dendrimer applications have extended from tumor cells to multidrug-resistant tumor cells. However, their transportation in multidrug-resistant tumor cells remains unclear.
Jie Zhang, Mingjuan Li, Mingyue Wang, Hang Xu, Zhuoxiang Wang, Yue Li, Baoyue Ding, Jianqing Gao   +7 more
doaj   +1 more source

The pair ceramide 1-phosphate/ceramide kinase regulates intracellular calcium and progesterone-induced human sperm acrosomal exocytosis

Frontiers in Cell and Developmental Biology, 2023
Before fertilization, spermatozoa must undergo calcium-regulated acrosome exocytosis in response to physiological stimuli such as progesterone and zona pellucida.
Cintia C. Vaquer, Laila Suhaiman, Laila Suhaiman, Martín A. Pavarotti, Rodolfo J. Arias, Rodolfo J. Arias, Anahí B. Pacheco Guiñazú, Gerardo A. De Blas, Gerardo A. De Blas, Silvia A. Belmonte, Silvia A. Belmonte   +10 more
doaj   +1 more source

Endocytosis and exocytosis of nanoparticles in mammalian cells

International Journal of Nanomedicine, 2014
Engineered nanoparticles that can be injected into the human body hold tremendous potential to detect and treat complex diseases. Understanding of the endocytosis and exocytosis mechanisms of nanoparticles is essential for safe and efficient therapeutic ...
Nuri Oh, Ji-Ho Park
semanticscholar   +1 more source

Increased Lysosomal Exocytosis Induced by Lysosomal Ca2+ Channel Agonists Protects Human Dopaminergic Neurons from α-Synuclein Toxicity

Journal of Neuroscience, 2019
The accumulation of misfolded proteins is a common pathological feature of many neurodegenerative disorders, including synucleinopathies such as Parkinson's disease (PD), which is characterized by the presence of α-synuclein (α-syn)-containing Lewy ...
T. Tsunemi, T. Perez-Rosello, Y. Ishiguro, Asako Yoroisaka, S. Jeon, Kana Hamada, Malini Rammonhan, Y. Wong, Zhong Xie, W. Akamatsu, Joseph R. Mazzulli, D. Surmeier, N. Hattori, D. Krainc   +13 more
semanticscholar   +1 more source

Glucocorticoid-mediated induction of ZBTB16 affects insulin secretion in human islets and EndoC-βH1 β-cells

iScience, 2023
Summary: Glucocorticoid use is associated with steroid-induced diabetes mellitus and impaired pancreatic β-cell insulin secretion. Here, the glucocorticoid-mediated transcriptomic changes in human pancreatic islets and the human insulin-secreting EndoC ...
Alexandros Karagiannopoulos, Efraim Westholm, Jones K. Ofori, Elaine Cowan, Jonathan L.S. Esguerra, Lena Eliasson   +5 more
doaj  

α-Synuclein: A Multifunctional Player in Exocytosis, Endocytosis, and Vesicle Recycling

Frontiers in Neuroscience, 2019
α-synuclein (α-Syn) is a presynaptic enriched protein involved in the pathogenesis of Parkinson’s disease. However, the physiological roles of α-Syn remain poorly understood.
Mingzhu Huang, Bianbian Wang, Xiaopeng Li, Chongluo Fu, Changhe Wang, Xinjiang Kang   +5 more
semanticscholar   +1 more source

Geometric and Electromagnetic Aspects of Fusion Pore Making [PDF]

Systems Biology 2 (2011), pp. 505-538, 2009
For regulated exocytosis, we model the morphology and dynamics of the making of the fusion pore or porosome as a cup-shaped lipoprotein structure (a dimple or pit) on the cytosol side of the plasma membrane. We describe the forming of the dimple by a free boundary problem.
arxiv   +1 more source

An inhibitory effect of extracellular Ca2+ on Ca2+-dependent exocytosis. [PDF]

PLoS ONE, 2011
AIM: Neurotransmitter release is elicited by an elevation of intracellular Ca(2+) concentration ([Ca(2+)](i)). The action potential triggers Ca(2+) influx through Ca(2+) channels which causes local changes of [Ca(2+)](i) for vesicle release. However, any
Wei Xiong, Tao Liu, Yeshi Wang, Xiaowei Chen, Lei Sun, Ning Guo, Hui Zheng, Lianghong Zheng, Martial Ruat, Weiping Han, Claire Xi Zhang, Zhuan Zhou   +11 more
doaj   +1 more source