Results 51 to 60 of about 167,613 (264)
Semisynthetic fluorescent pH sensors for imaging exocytosis and endocytosis
Nature Communications, 2017 The GFP-based superecliptic pHluorin (SEP) enables detection of exocytosis and endocytosis, but its performance has not been duplicated in red fluorescent protein scaffolds.
M. Martineau +7 more
semanticscholar +1 more source
Clinical Epigenetics, 2017 Background Subjects born with low birth weight (LBW) display a more energy-conserving response to fasting compared with normal birth weight (NBW) subjects.
Line Hjort +7 more
doaj +1 more source
Architecture of the Synaptotagmin-SNARE Machinery for Neuronal Exocytosis
Nature, 2015 Synaptotagmin-1 and neuronal SNARE proteins have central roles in evoked synchronous neurotransmitter release; however, it is unknown how they cooperate to trigger synaptic vesicle fusion.
Qiangjun Zhou +29 more
semanticscholar +1 more source
Glucocorticoid induces human beta cell dysfunction by involving riborepressor GAS5 LincRNA
Molecular Metabolism, 2020 Objective: A widely recognized metabolic side effect of glucocorticoid (GC) therapy is steroid-induced diabetes mellitus (DM). However, studies on the molecular basis of GC-induced pancreatic beta cell dysfunction in human beta cells are lacking.
Jonathan L.S. Esguerra +8 more
doaj
Cell Reports, 2012 Although calcium influx triggers endocytosis at many synapses and non-neuronal secretory cells, the identity of the calcium channel is unclear. The plasma membrane voltage-dependent calcium channel (VDCC) is a candidate, and it was recently proposed that
Lei Xue +7 more
doaj +1 more source
Phase transitions in biological membranes [PDF]
Book chapter in: C. Demetzos and N. Pippa (eds.), Thermodynamics
and Biophysics of Biomedical Nanosystems, Series in BioEngineering, Springer
Nature Singapore 2019, 2018 Native membranes of biological cells display melting transitions of their lipids at a temperature of 10-20 degrees below body temperature. Such transitions can be observed in various bacterial cells, in nerves, in cancer cells, but also in lung surfactant.
arxiv +1 more source
Cell-Type-Specific Differences in KDEL Receptor Clustering in Mammalian Cells [PDF]
PLOS ONE 15, e0235864 (2020), 2020 In eukaryotic cells, KDEL receptors (KDELRs) facilitate the retrieval of endoplasmic reticulum (ER) luminal proteins from the Golgi compartment back to the ER. Apart from the well-documented retention function, recent findings reveal that the cellular KDELRs have more complex roles, e.g.
arxiv +1 more source
Anaphylactic Degranulation of Mast Cells: Focus on Compound Exocytosis
Journal of Immunology Research, 2019 Anaphylaxis is a notorious type 2 immune response which may result in a systemic response and lead to death. A precondition for the unfolding of the anaphylactic shock is the secretion of inflammatory mediators from mast cells in response to an allergen,
Ofir Klein, Ronit Sagi-Eisenberg
doaj +1 more source
Spike-by-Spike Frequency Analysis of Amperometry Traces Provides Statistical Validation of Observations in the Time Domain [PDF]
arXiv, 2023 Amperometry is a commonly used electrochemical method for studying the process of exocytosis in real-time. Given the high precision of recording that amperometry procedures offer, the volume of data generated can span over several hundreds of megabytes to a few gigabytes and therefore necessitates systematic and reproducible methods for analysis ...
arxiv
Journal of Biological Chemistry, 2016 Neutrophils constitute the first line of cellular defense in response to bacterial and fungal infections and rely on granular proteins to kill microorganisms, but uncontrolled secretion of neutrophil cargos is injurious to the host and should be closely ...
J. Johnson +9 more
semanticscholar +1 more source