Results 111 to 120 of about 22,111 (197)

A nuclease specific to lepidopteran insects suppresses RNAi [PDF]

, 2018
More than 70% of all agricultural pests are insects in the order Lepidoptera, which, unlike other related insect orders, are not very sensitive to RNAi, limiting genetic studies of this insect group.
Christiaens, Olivier, Fan, Yu-Jie, Guan, Ruo-Bing, Hu, Shao-Ru, Li, Hai-Chao, Miao, Xue-Xia, Smagghe, Guy   +6 more
core   +2 more sources

A New Model of Gastric Pre-neoplasia Induced by Aberrant ADAR1-mediated Double-stranded RNA SignalingSummaryWhat You Need to Know

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Recent evidence suggests that endogenously derived double-stranded RNA (dsRNA) impacts multiple cellular processes, although its role in epithelial injury remains understudied.
Angela M. Halstead, Chinye Nwokolo, Stella Hoft, Jinsheng Yu, Lifei Zhu, Brendan Tuley, Nancy Vargas, RuiRui Liu, Francisco Ramirez Victorino, Simrin Phatak, Wandy Beatty, Chun-Kan Chen, Richard DiPaolo, Paul Cliften, Tarin M. Bigley, José B. Sáenz   +15 more
doaj   +1 more source

RNA Interference by Production of Short Hairpin dsRNA in ES Cells, Their Differentiated Derivatives, and in Somatic Cell Lines [PDF]

, 2003
dsRNA of several hundred nucleotides in length is effective at interfering with gene expression in mouse oocytes, pre-implantation embryos, and embryonic stem (ES) cells but is not as efficient in differentiated cell lines.
Glover, D. M., Grabarek, J. B., Plusa, B., Wianny, F., Zernicka-Goetz, M.   +4 more
core   +1 more source

Identification of pathogenicity determinants in ToLCNDV and their RNAi-based knockdown for disease management in Nicotiana benthamiana and tomato plants

Frontiers in Microbiology
Begomovirus solanumdelhiense (tomato leaf curl New Delhi virus, ToLCNDV), is member of the genus Begomovirus, family Geminiviridae, is a prolific bipartite whitefly transmitted begomovirus in the Indian sub-continent has a wide host range, including ...
Mehulee Sarkar, Dipinte Gupta, Oinam Washington Singh, Samrat Paul, Ravinder Kumar, Bikash Mandal, Anirban Roy   +6 more
doaj   +1 more source

A petunia ethylene-responsive element binding factor, PhERF2, plays an important role in antiviral RNA silencing. [PDF]

, 2016
Virus-induced RNA silencing is involved in plant antiviral defense and requires key enzyme components, including RNA-dependent RNA polymerases (RDRs), Dicer-like RNase III enzymes (DCLs), and Argonaute proteins (AGOs).
Jiang, Cai-Zhong, Nandety, Raja Sekhar, Niu, Lixin, Reid, Michael S, Sun, Daoyang, Zhang, Yanlong   +5 more
core   +1 more source

RNA interference is ineffective as a routine method for gene silencing in chick embryos as monitored by fgf8 silencing.

, 2013
The in vivo accessibility of the chick embryo makes it a favoured model system for experimental developmental biology. Although the range of available techniques now extends to miss-expression of genes through in ovo electroporation, it remains difficult
Bueno i Torrens, David, 1965-, Hernández Hernández, Victor   +1 more
core  

Novel Cell type-specific aptamer-siRNA delivery system for HIV-1 therapy [PDF]

, 2007
The successful use of small interfering RNAs (siRNAs) for therapeutic purposes requires safe and efficient delivery to specific cells and tissues. Here we demonstrate cell type-specific delivery of anti-HIV siRNAs via fusion to an anti-gp120 aptamer. The
Haitang Li, Jiehua Zhou, John Rossi, John Zaia, Shirley Li   +4 more
core   +2 more sources

Fatty Acid Synthase binds endogenous dsRNAs and dampens the innate immune response to exogenous dsRNAs by limiting their accumulation

Abstract In mammalian cells, the presence of double-stranded RNA (dsRNA) in the cytoplasm is a danger signal indicative of viral infection. Cells establish and maintain an antiviral state via the production of interferon (IFN) in response to the detection of viral dsRNAs by specialized RNA-binding proteins (RBPs). In addition to viral dsRNA,
Charline Pasquier, Mélanie Messmer, Lisanne Knol, Johana Chicher, Richard Patryk Ngondo, Sébastien Pfeffer, Erika Girardi   +6 more
openaire   +1 more source

Orchestrating innate immunity through RNA editing and helicase activity: ADAR1, dsRNA sensors, and tumor immune evasion

Frontiers in Cell and Developmental Biology
Dysregulated dsRNA editing and RNA metabolism in cancer contribute to immune evasion, highlighting the critical role of RNA structural regulation in disease.
Moeko Minakuchi, Joseph M. Salvino, Jessie Villanueva   +2 more
doaj   +1 more source

U.S. Patent Literature Survey of Agrobacterium-Mediated Transformation of Sweet Potato (Ipomoea Batatas) [PDF]

, 2007
A team of researchers and patent information scientists at Franklin Pierce Law Center were asked to evaluate the patent and literature landscape related to the Agrobacterium-mediated transformation in sweet potato with respect to the U.S.
Cavicchi, Jon R., Kowalski, Stanley P., Murthy, J. Jaya, Vartak, Rahul R.   +3 more
core   +1 more source