Results 91 to 100 of about 838,049 (387)
ExonThis review examines the chemical modulation and biochemical interactions of fermenting the oligo-, di-, monosaccharides, or polymers (FODMAPs) and how they affect the composition and function of the gut microbiota. This study critically investigates the
Shefeena Ahamed Sherafudeen +1 more
doaj +1 more source
De novo prediction of PTBP1 binding and splicing targets reveals unexpected features of its RNA recognition and function. [PDF]
, 2014 The splicing regulator Polypyrimidine Tract Binding Protein (PTBP1) has four RNA binding domains that each binds a short pyrimidine element, allowing recognition of diverse pyrimidine-rich sequences.
Black, Douglas L +5 more
core +4 more sources
Cell, 2016 Exondys 51 is the first therapy for Duchenne muscular dystrophy (DMD) to have been granted accelerated approval by the FDA. Approval was granted based on using dystrophin expression as a surrogate marker. Exondys 51 targets DMD exon 51 for skipping to restore the reading frame for 13% of Duchenne patients.
Courtney S, Young, April D, Pyle
openaire +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
ExonProbiotics, defined as live microorganisms that offer health benefits when consumed in adequate amounts, have traditionally been used to maintain gastrointestinal (GI) health.
Debtosh Patra
doaj +1 more source
Exons, introns and DNA thermodynamics
, 2005 The genes of eukaryotes are characterized by protein coding fragments, the exons, interrupted by introns, i.e. stretches of DNA which do not carry any useful information for the protein synthesis.
A. Stoltzfus +11 more
core +1 more source
The Jena Library of Biological Macromolecules - JenaLib [PDF]
, 2009 The JenaLib database ("www.fli-leibniz.de/IMAGE.html":http://www.fli-leibniz.de/IMAGE.html) offers value-added information for all Protein Data Bank (PDB) and Nucleic Acid Database (NDB) entries.
Juergen Suehnel, Rolf Huehne
core +2 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Study of Radioprotection by Silver Nanoparticle-Ascorbic Acid Monoglucoside Complex
ExonIonizing radiations affect various aspects of human life, especially in areas pertaining to radiotherapy of cancer, food preservation, the agriculture industry and power generation; there is a need to develop an effective and nontoxic radioprotector. The
Thulasi Venugopalan
doaj +1 more source
Genetic variation affecting exon skipping contributes to brain structural atrophy in Alzheimer's disease [PDF]
, 2018 Genetic variation in cis-regulatory elements related to splicing machinery and splicing regulatory elements (SREs) results in exon skipping and undesired protein products.
Alzheimer’s Disease Neuroimaging Initiative +8 more
core