Results 161 to 170 of about 586,929 (366)

Neuroimmune Microenvironment Reprogramming via Immuno‐piezoelectric Transducers for Synergistic Stem Cell Therapy in Traumatic Brain Injury

Advanced Materials, EarlyView.
A novel immuno‐piezoelectric transducer is innovatively developed. This device promotes neural stem cell (NSC) differentiation and maturation via ultrasound‐induced electrical stimulation and it amplifies the therapeutic efficacy of NSC in traumatic brain injury (TBI) by modulating the immune microenvironment. This piezoelectric transducer with “immune‐
Linlin Liang, Xin Li, Kai Hu, Pingqiang Cai, Jianwu Wang, Jing Yu, Shasha Wang, Yuwei Zhao, Changgeng Xu, Siwei Li, Hong Liu, Changyong Wang, Jin Zhou   +12 more
wiley   +1 more source

Identification of a Carcinoembryonic Antigen Gene Family in the Rat [PDF]

, 1989
The existence of a carcinoembryonic antigen (CEA)-like gene family in rat has been demonstrated through isolation and sequencing of the N- terminal domain exons of presumably five discrete genes (rnCGM1-5).
Barnert, Sabine, Kleist, Sabine von, Kodelja, Vitam, Lucas, Kurt, Thompson, John A., Zimmermann, Wolfgang   +5 more
core  

Systematic revelation and meditation on the significance of long exons using representative eukaryotic genomes

BMC Genomics
Background Long exons/introns are not evenly distributed in the genome, but the biological significance of this phenomenon remains elusive. Materials and methods Exon properties were analyzed in seven well-annotated reference genomes, including human and
Yuange Duan, Qi Cao
doaj   +1 more source

Excessive DNA Double‐Strand Breaks–Associated 3D Genome Reorganization Contributes to Neural Tube Defects with Folate Deficiency

Advanced Science, EarlyView.
Neural tube defects (NTDs) are among the most common congenital malformations. However, the underlying etiology and mechanism remain elusive. Here, the role of DNA double‐strand breaks (DSBs) in 3D genome organization within the NTDs with folate deficiency is reported.
Ting Zhang, Lin Lin, Jianting Li, Caihua Li, Shengjun Liang, Xuemei Bai, Fang Wang, Yihua Bao, Dan Guo, Xiaochen Bo, Hao Li, Hebing Chen, Qiu Xie   +12 more
wiley   +1 more source

Image1_The Dysferlin Transcript Containing the Alternative Exon 40a is Essential for Myocyte Functions.PNG

, 2021
Océane Ballouhey (11744309), Sébastien Courrier (11744312), Virginie Kergourlay (11744315), Svetlana Gorokhova (585388), Mathieu Cerino (11744318), Martin Krahn (162235), Nicolas Lévy (13383), Marc Bartoli (162219)   +7 more
openalex   +2 more sources

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Investigation of Mutations in Exons 15 and 18 of MYBPC3 Gene in Hypertrophic Cardiomyopathy Patients [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2015
Background: Hypertrophic cardiomyopathy (HCM) is a various collection of heart diseases with autosomal dominant inheritance affecting 0.2% of the global population.
Behnaz Sadat Abedi, Seyedeh Zohreh kiyani, Morteza Hashemzadeh Chaleshtori, Shahrbanoo Parchami, Abbas Doosti   +4 more
doaj  

TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD

Science, 2015
Jonathan P. Ling, O. Pletnikova, J. Troncoso, P. Wong   +3 more
semanticscholar   +1 more source

Data from <i>MET</i> Amplification and Exon 14 Splice Site Mutation Define Unique Molecular Subgroups of Non–Small Cell Lung Carcinoma with Poor Prognosis

, 2023
Joanna H. Tong, Sai F. Yeung, Anthony W.H. Chan, Lau Y. Chung, Shuk L. Chau, Raymond Wai Ming Lung, Carol Y. Tong, Chit Chow, Edith K.Y. Tin, Yau H. Yu, Hui Li, Yi Pan, Wing P. Chak, Calvin S.H. Ng, Tony Mok, Ka‐Fai To   +15 more
openalex   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source