Results 201 to 210 of about 419,485 (330)

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

Large-scale RNA-Seq mining reveals ciclopirox olamine induces TDP-43 cryptic exons. [PDF]

Nat Commun
Sinha IR, Sandal PS, Spence H, Burns GD, Mallika AP, Abbasinejad F, Irwin KE, Cruz ALF, Wang V, Marx SR, Rodríguez JL, Langmead B, Gregory JM, Wong PC, Ling JP.   +14 more
europepmc   +1 more source

A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing

Advanced Science, EarlyView.
This study discoveries that EBV EBNA1 behaves as a prion‐like protein, verified using cell‐based assays and the Saccharomyces cerevisiae Sup35p prion identification system. The prion‐like domain of EBNA1 drives liquid–liquid phase separation. EBNA1 interacts with the splicing factor SRSF1 to regulate the expression of the SRRM1 splicing isoforms ...
Xiaoyue Zhang, Zhengshuo Li, Run Zheng, Xiang Zheng, Jia Wang, Can Liu, Yangge Wu, Yuqing Wen, Chunlin Ou, Songqing Fan, Chenxiao Xu, Junrui Tian, Qun Yan, Hao Nan, Xiaodong Xu, Hui Wang, Qiu Peng, Jian Ma   +17 more
wiley   +1 more source

A founder BRCA1 exonic duplication involving breakpoint in T2T reference genome-specific region results in constitutional fusion transcript. [PDF]

NPJ Genom Med
Schwartz M, Filser M, Merchadou K, Lemaitre E, Abidallah K, Tenreiro H, Dubois D'enghien C, Rapinat A, Pierre-Noel E, Suybeng V, Espenel M, Baulande S, Adams S, Remenieras A, Renaud C, Aucouturier C, Delnatte C, Garrec C, Renault V, Golmard L, Fourme E, Masliah-Planchon J, Caputo SM.   +22 more
europepmc   +1 more source

A first exon-encoded domain of E1A sufficient for posttranslational modification, nuclear-localization, and induction of adenovirus E3 promoter expression in Xenopus oocytes.

, 1985
Joel D. Richter, Paul R. Young, N C Jones, B Krippl, Martin Rosenberg, B Ferguson   +5 more
openalex   +1 more source

Splice site mutation in the human protein C gene associated with venous thrombosis: demonstration of exon skipping by ectopic transcript analysis [PDF]

, 1993
Bent Lind, WW van Solinge, M. Schwartz, S Thorsen   +3 more
openalex   +1 more source

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

Advanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen, Jianqiang Yang, David O. Popoola, Fan Yang, Yajie Liu, Dongsheng Wang, Zhaohui S. Qin, Zhengjia Chen, Nabil F. Saba, Zhuo G. Chen, Yamin Li, Yong Teng   +11 more
wiley   +1 more source

The Length of the Downstream Exon and the Substitution of Specific Sequences Affect Pre-mRNA Splicing in Vitro

, 1988
Paul J. Furdon, Ryszard Kole
openalex   +3 more sources

The Diagnostic Value of Copy Number Variants in Genetic Cardiomyopathies and Channelopathies. [PDF]

J Cardiovasc Dev Dis
Caputo V, Visconti VV, Marchionni E, Ferradini V, Balsano C, De Vico P, Calò L, Mango R, Novelli G, Sangiuolo F.   +9 more
europepmc   +1 more source

Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity.

, 1989
Dennis B. Lubahn, T. R. Brown, J A Simental, Henry N. Higgs, Claude J. Migeon, Elizabeth M. Wilson, Frank S. French   +6 more
openalex   +1 more source