Results 1 to 10 of about 14,025 (272)

Tick-borne flavivirus exoribonuclease-resistant RNAs contain a double loop structure [PDF]

Nature Communications
Viruses from the Flaviviridae family contain human relevant pathogens that generate subgenomic noncoding RNAs during infection using structured exoribonuclease resistant RNAs (xrRNAs).
Conner J. Langeberg, Matthew J. Szucs, Madeline E. Sherlock, Quentin Vicens, Jeffrey S. Kieft   +4 more
doaj   +4 more sources

The 3' to 5' Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human Disease [PDF]

Biomolecules, 2015
DIS3 is a conserved exoribonuclease and catalytic subunit of the exosome, a protein complex involved in the 3' to 5' degradation and processing of both nuclear and cytoplasmic RNA species.
Sophie R. Robinson, Antony W. Oliver, Timothy J. Chevassut, Sarah F. Newbury   +3 more
doaj   +5 more sources

Processing of RNA Containing 8-Oxo-7,8-Dihydroguanosine (8-oxoG) by the Exoribonuclease Xrn-1 [PDF]

Frontiers in Molecular Biosciences, 2021
Understanding how oxidatively damaged RNA is handled intracellularly is of relevance due to the link between oxidized RNA and the progression/development of some diseases as well as aging.
Cheyenne N. Phillips, Shawn Schowe, Conner J. Langeberg, Namoos Siddique, Erich G. Chapman, Marino J. E. Resendiz   +5 more
doaj   +3 more sources

Exoribonuclease RNase R protects Antarctic Pseudomonas syringae Lz4W from DNA damage and oxidative stress. [PDF]

Appl Environ Microbiol, 2023
RNase R is a highly processive, 3′–5′ exoribonuclease involved in RNA degradation, maturation, and processing in bacteria. In Pseudomonas syringae Lz4W, RNase R interacts with RNase E to form the RNA degradosome complex and is essential for growth at low
Mittal P, Sipani R, Pandiyan A, Sulthana S, Sinha AK, Hussain A, Ray MK, Pavankumar TL.   +7 more
europepmc   +4 more sources

Xrn1/Pacman affects apoptosis and regulates expression of hid and reaper [PDF]

Biology Open, 2015
Programmed cell death, or apoptosis, is a highly conserved cellular process that is crucial for tissue homeostasis under normal development as well as environmental stress.
Joseph A. Waldron, Christopher I. Jones, Benjamin P. Towler, Amy L. Pashler, Dominic P. Grima, Stephen Hebbes, Samuel H. Crossman, Maria V. Zabolotskaya, Sarah F. Newbury   +8 more
doaj   +4 more sources

Dis3l2 is essential for neural crest survival by modulating Akt signaling [PDF]

Cell Communication and Signaling
DIS3-like 3’-5’ exoribonuclease 2 (DIS3L2), an exoribonuclease, is known to preferentially degrade uridylated RNA substrates, miRNAs, and ncRNAs. Recent reports show that DIS3L2 also plays a key role in cell proliferation and tumor growth.
Sian D’Silva, Tuhina Prasad, Megha Kumar   +2 more
doaj   +2 more sources

Regulation of co-translational mRNA decay by PAP and DXO1 in Arabidopsis [PDF]

BMC Plant Biology
Background mRNA decay is central in the regulation of mRNA homeostasis in the cell. The recent discovery of a co-translational mRNA decay pathway (also called CTRD) has changed our understanding of the mRNA decay process.
Marie-Christine Carpentier, Anne-Elodie Receveur, Adrien Cadoudal, Rémy Merret   +3 more
doaj   +2 more sources

RPA transforms RNase H1 to a bidirectional exoribonuclease for processive RNA–DNA hybrid cleavage [PDF]

Nature Communications
RNase H1 has been acknowledged as an endoribonuclease specializing in the internal degradation of the RNA moiety within RNA–DNA hybrids, and its ribonuclease activity is indispensable in multifaceted aspects of nucleic acid metabolism.
Yanan Li, Chao Liu, Xinshuo Jia, Lulu Bi, Zhiyun Ren, Yilin Zhao, Xia Zhang, Lijuan Guo, Yanling Bao, Cong Liu, Wei Li, Bo Sun   +11 more
doaj   +2 more sources

Conserved mechanism of Xrn1 regulation by glycolytic flux and protein aggregation [PDF]

Heliyon
The regulation of gene expression in eukaryotes relies largely on the action of exoribonucleases, evolutionarily conserved enzymes that digest decapped messenger RNAs in the 5’-3’ direction.
Satyendra Mondal, Jakub Zahumensky, Petra Vesela, Jan Malinsky   +3 more
doaj   +2 more sources

Genome-wide in silico screen for CCCH-type zinc finger proteins of Trypanosoma brucei, Trypanosoma cruzi and Leishmania major [PDF]

BMC Genomics, 2010
Background CCCH type zinc finger proteins are RNA binding proteins with regulatory functions at all stages of mRNA metabolism. The best-characterized member, tritetraproline (TTP), binds to AU rich elements in 3' UTRs of unstable mRNAs, mediating their ...
Carrington Mark, Kimblin Nicola C, Kramer Susanne   +2 more
doaj   +3 more sources