Results 1 to 10 of about 18,714 (239)

RPA transforms RNase H1 to a bidirectional exoribonuclease for processive RNA–DNA hybrid cleavage [PDF]

Nature Communications
RNase H1 has been acknowledged as an endoribonuclease specializing in the internal degradation of the RNA moiety within RNA–DNA hybrids, and its ribonuclease activity is indispensable in multifaceted aspects of nucleic acid metabolism.
Yanan Li, Chao Liu, Xinshuo Jia, Lulu Bi, Zhiyun Ren, Yilin Zhao, Xia Zhang, Lijuan Guo, Yanling Bao, Cong Liu, Wei Li, Bo Sun   +11 more
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The 3' to 5' Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human Disease [PDF]

Biomolecules, 2015
DIS3 is a conserved exoribonuclease and catalytic subunit of the exosome, a protein complex involved in the 3' to 5' degradation and processing of both nuclear and cytoplasmic RNA species.
Sophie R. Robinson, Antony W. Oliver, Timothy J. Chevassut, Sarah F. Newbury   +3 more
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Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAs [PDF]

Nature Communications, 2018
Subgenomic flavivirus RNAs are generated by a host exoribonuclease and play an important role in virus replication and pathogenesis. Here, the authors show the mechanism by which subgenomic flavivirus RNAs are generated and identify two structurally ...
Andrea MacFadden, Zoe O’Donoghue, Patricia A. G. C. Silva, Erich G. Chapman, René C. Olsthoorn, Mark G. Sterken, Gorben P. Pijlman, Peter J. Bredenbeek, Jeffrey S. Kieft   +8 more
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Discoveries of Exoribonuclease-Resistant Structures of Insect-Specific Flaviviruses Isolated in Zambia [PDF]

Viruses, 2020
To monitor the arthropod-borne virus transmission in mosquitoes, we have attempted both to detect and isolate viruses from 3304 wild-caught female mosquitoes in the Livingstone (Southern Province) and Mongu (Western Province) regions in Zambia in 2017. A
Christida E. Wastika, Hayato Harima, Michihito Sasaki, Bernard M. Hang’ombe, Yuki Eshita, Yongjin Qiu, William W. Hall, Michael T. Wolfinger, Hirofumi Sawa, Yasuko Orba   +9 more
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An African tick flavivirus forming an independent clade exhibits unique exoribonuclease-resistant RNA structures in the genomic 3′-untranslated region [PDF]

Scientific Reports, 2021
Tick-borne flaviviruses (TBFVs) infect mammalian hosts through tick bites and can cause various serious illnesses, such as encephalitis and hemorrhagic fevers, both in humans and animals.
Hayato Harima, Yasuko Orba, Shiho Torii, Yongjin Qiu, Masahiro Kajihara, Yoshiki Eto, Naoya Matsuta, Bernard M. Hang’ombe, Yuki Eshita, Kentaro Uemura, Keita Matsuno, Michihito Sasaki, Kentaro Yoshii, Ryo Nakao, William W. Hall, Ayato Takada, Takashi Abe, Michael T. Wolfinger, Martin Simuunza, Hirofumi Sawa   +19 more
doaj   +2 more sources

Xrn1/Pacman affects apoptosis and regulates expression of hid and reaper [PDF]

Biology Open, 2015
Programmed cell death, or apoptosis, is a highly conserved cellular process that is crucial for tissue homeostasis under normal development as well as environmental stress.
Joseph A. Waldron, Christopher I. Jones, Benjamin P. Towler, Amy L. Pashler, Dominic P. Grima, Stephen Hebbes, Samuel H. Crossman, Maria V. Zabolotskaya, Sarah F. Newbury   +8 more
doaj   +4 more sources

The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity [PDF]

Frontiers in Microbiology, 2019
Among RNA viruses, the order Nidovirales stands out for including viruses with the largest RNA genomes currently known. Nidoviruses employ a complex RNA-synthesizing machinery comprising a variety of non-structural proteins (nsps).
Natacha S. Ogando, Francois Ferron, Francois Ferron, Etienne Decroly, Bruno Canard, Clara C. Posthuma, Eric J. Snijder   +6 more
doaj   +2 more sources

The coronavirus nsp14 exoribonuclease interface with the cofactor nsp10 is essential for efficient virus replication and enzymatic activity [PDF]

Journal of Virology
Coronaviruses (CoVs) encode non-structural proteins (nsp’s) 1–16, which assemble to form replication-transcription complexes that function in viral RNA synthesis.
Samantha L. Grimes, Brook E. Heaton, Mackenzie L. Anderson, Katie Burke, Laura Stevens, Xiaotao Lu, Nicholas S. Heaton, Mark R. Denison, Jordan Anderson-Daniels   +8 more
doaj   +2 more sources

Dis3l2 is essential for neural crest survival by modulating Akt signaling [PDF]

Cell Communication and Signaling
DIS3-like 3’-5’ exoribonuclease 2 (DIS3L2), an exoribonuclease, is known to preferentially degrade uridylated RNA substrates, miRNAs, and ncRNAs. Recent reports show that DIS3L2 also plays a key role in cell proliferation and tumor growth.
Sian D’Silva, Tuhina Prasad, Megha Kumar   +2 more
doaj   +2 more sources

Tick-borne flavivirus exoribonuclease-resistant RNAs contain a double loop structure [PDF]

Nature Communications
Viruses from the Flaviviridae family contain human relevant pathogens that generate subgenomic noncoding RNAs during infection using structured exoribonuclease resistant RNAs (xrRNAs).
Conner J. Langeberg, Matthew J. Szucs, Madeline E. Sherlock, Quentin Vicens, Jeffrey S. Kieft   +4 more
doaj   +2 more sources