Results 11 to 20 of about 14,025 (272)
Shared properties and singularities of exoribonuclease-resistant RNAs in viruses
Computational and Structural Biotechnology Journal, 2021 What viral RNA genomes lack in size, they make up for in intricacy. Elaborate RNA structures embedded in viral genomes can hijack essential cellular mechanisms aiding virus propagation.
Quentin Vicens, Jeffrey S. Kieft
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Frontiers in Microbiology, 2019 Among RNA viruses, the order Nidovirales stands out for including viruses with the largest RNA genomes currently known. Nidoviruses employ a complex RNA-synthesizing machinery comprising a variety of non-structural proteins (nsps).
Natacha S. Ogando +6 more
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The roles of the exoribonucleases DIS3L2 and XRN1 in disease [PDF]
Biochemical Society Transactions, 2016 RNA degradation is a vital post-transcriptional process which ensures that transcripts are maintained at the correct level within the cell. DIS3L2 and XRN1 are conserved exoribonucleases which are critical for the degradation of cytoplasmic RNAs ...
Jones, Christopher I +3 more
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The coronavirus proofreading exoribonuclease mediates extensive viral recombination.
PLoS Pathogens, 2021 Recombination is proposed to be critical for coronavirus (CoV) diversity and emergence of SARS-CoV-2 and other zoonotic CoVs. While RNA recombination is required during normal CoV replication, the mechanisms and determinants of CoV recombination are not ...
Jennifer Gribble +8 more
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Viruses, 2018 The RNA3 species of the beet necrotic yellow vein virus (BNYVV), a multipartite positive-stranded RNA phytovirus, contains the ‘core’ nucleotide sequence required for its systemic movement in Beta macrocarpa.
Alyssa Flobinus +9 more
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Scientific Reports, 2021 Tick-borne flaviviruses (TBFVs) infect mammalian hosts through tick bites and can cause various serious illnesses, such as encephalitis and hemorrhagic fevers, both in humans and animals.
Hayato Harima +19 more
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Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAs
Nature Communications, 2018 Subgenomic flavivirus RNAs are generated by a host exoribonuclease and play an important role in virus replication and pathogenesis. Here, the authors show the mechanism by which subgenomic flavivirus RNAs are generated and identify two structurally ...
Andrea MacFadden +8 more
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A New Subclass of Exoribonuclease-Resistant RNA Found in Multiple Genera of
mBio, 2020 Viruses have developed innovative strategies to exploit the cellular machinery and overcome the antiviral defenses of the host, often using specifically structured RNA elements.
Matthew J. Szucs +4 more
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Alterations of the transcriptome of Sulfolobus acidocaldarius by exoribonuclease aCPSF2.
PLoS ONE, 2013 Recent studies identified a 5´ to 3´ exoribonuclease termed Sso-RNase J in the crenarchaeon Sulfolobus solfataricus (Sso), which has been reclassified to the aCPSF2 (archaeal cleavage and polyadenylation specificity factor 2) group of β-CASP proteins. In
Birgit Märtens +7 more
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The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagy [PDF]
Autophagy, 2018 Macroautophagy/autophagy is a conserved catabolic process that promotes survival during stress. Autophagic dysfunction is associated with pathologies such as cancer and neurodegenerative diseases. Thus, autophagy must be strictly modulated at multiple levels (transcriptional, post-transcriptional, translational and post-translational) to prevent ...
Elizabeth Delorme-Axford +7 more
semanticscholar +5 more sources