Results 11 to 20 of about 18,714 (239)

Structural and catalytic diversity of coronavirus proofreading exoribonuclease [PDF]

Nature Communications
The coronavirus proofreading exoribonuclease (ExoN) is essential for genome fidelity and immune evasion of the viruses. Despite its critical roles in the viral life cycle, it is unclear how ExoNs across different coronaviruses diverge in their structures
Yu Li, Xiaocong Cao, Lauren M. Recker, Yang Yang, Chang Liu   +4 more
doaj   +2 more sources

Regulation of co-translational mRNA decay by PAP and DXO1 in Arabidopsis [PDF]

BMC Plant Biology
Background mRNA decay is central in the regulation of mRNA homeostasis in the cell. The recent discovery of a co-translational mRNA decay pathway (also called CTRD) has changed our understanding of the mRNA decay process.
Marie-Christine Carpentier, Anne-Elodie Receveur, Adrien Cadoudal, Rémy Merret   +3 more
doaj   +2 more sources

The coronavirus proofreading exoribonuclease mediates extensive viral recombination.

PLoS Pathogens, 2021
Recombination is proposed to be critical for coronavirus (CoV) diversity and emergence of SARS-CoV-2 and other zoonotic CoVs. While RNA recombination is required during normal CoV replication, the mechanisms and determinants of CoV recombination are not ...
Jennifer Gribble, Laura J Stevens, Maria L Agostini, Jordan Anderson-Daniels, James D Chappell, Xiaotao Lu, Andrea J Pruijssers, Andrew L Routh, Mark R Denison   +8 more
doaj   +4 more sources

Immunosuppressive arenaviral exoribonuclease

Oncotarget, 2015
Arenaviruses cause up to 500,000 zoonotic infections per year in endemic areas of Africa and South America and can lead to severe and lethal hemorrhagic fever (HF) symptoms [1]. Currently, there is no specific antiviral drug or vaccine available for the treatment of these infections, with the exception of the Candid #1 vaccine that has successfully ...
Bjoern Meyer, Hinh Ly
openalex   +3 more sources

Rho-dependent termination and RNase E-mediated cleavage: dual pathways for RNA 3′ end processing in polycistronic mRNA [PDF]

Journal of Bacteriology
“Pre-full-length” transcripts are produced at the end of the polycistronic galactose (gal) operon, 5′ galE-galT-galK-galM 3′, via Rho-dependent transcription termination (RDT) and -independent transcription termination.
Heung Jin Jeon, Monford Paul Abishek N, Xun Wang, Heon M. Lim   +3 more
doaj   +2 more sources

Conserved mechanism of Xrn1 regulation by glycolytic flux and protein aggregation [PDF]

Heliyon
The regulation of gene expression in eukaryotes relies largely on the action of exoribonucleases, evolutionarily conserved enzymes that digest decapped messenger RNAs in the 5’-3’ direction.
Satyendra Mondal, Jakub Zahumensky, Petra Vesela, Jan Malinsky   +3 more
doaj   +2 more sources

Xrn1 Exoribonuclease—An Intrinsic Marker of Yeast Population Growth

Frontiers in Bioscience-Elite
Background: Xrn1 exoribonuclease is the major mRNA degradation enzyme in Saccharomyces cerevisiae. In exponentially growing cells, Xrn1 is localised in the yeast cells and directs the degradation of mRNA molecules.
Tomas Grousl, Tomas Vomastek
doaj   +3 more sources

Exoribonucleases as Modulators of Virulence in Pathogenic Bacteria [PDF]

Frontiers in Cellular and Infection Microbiology, 2012
Pathogenic bacteria are responsible for severe diseases worldwide. RNA stability is a major player controlling the expression of virulence factors. Ribonucleases (RNases) are the enzymes responsible for the maturation and degradation of RNA molecules (Arraiano et al., 2010; Silva et al., 2011).
Rute G. Matos, Cátia Bárria, Vânia Pobre, José M. Andrade, Cecília M. Arraiano   +4 more
openalex   +4 more sources

Regulation of R-Loop Dynamics by Proteins and Long Noncoding RNAs: An Emerging Paradigm for Cancer Treatment. [PDF]

Cancer Sci
R‐loops are three‐stranded nucleic acid structures whose dysregulation leads to genomic instability and cancer progression. This review summarizes the protein and lncRNA machineries that regulate R‐loop dynamics and discusses the therapeutic potential of targeting these pathways in cancer.
Suzuki MM, Shinjo K, Nishimura T, Kondo Y.   +3 more
europepmc   +2 more sources

Computational Characterizations of the Interactions Between the Pontacyl Violet 6R and Exoribonuclease as a Potential Drug Target Against SARS-CoV-2

Frontiers in Chemistry, 2021
We report a molecular-docking and virtual-screening-based identification and characterization of interactions of lead molecules with exoribonuclease (ExoN) enzyme in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). From previously identified
Rangika Munaweera, Ying S. Hu
doaj   +1 more source