Results 31 to 40 of about 14,025 (272)

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis. [PDF]

FEBS Lett
The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Gilet L, Leroy M, Maes A, Condon C, Braun F.   +4 more
europepmc   +2 more sources

Computational Characterizations of the Interactions Between the Pontacyl Violet 6R and Exoribonuclease as a Potential Drug Target Against SARS-CoV-2

Frontiers in Chemistry, 2021
We report a molecular-docking and virtual-screening-based identification and characterization of interactions of lead molecules with exoribonuclease (ExoN) enzyme in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). From previously identified
Rangika Munaweera, Ying S. Hu
doaj   +1 more source

MUT-7 exoribonuclease activity and localization are mediated by an ancient domain. [PDF]

Nucleic Acids Res
Busetto V, Pshanichnaya L, Lichtenberger R, Hann S, Ketting RF, Falk S.   +5 more
europepmc   +2 more sources

Regulation of the conserved 3′‐5′ exoribonuclease EXOSC10/Rrp6 during cell division, development and cancer

Biological Reviews of The Cambridge Philosophical Society, 2021
The conserved 3′‐5′ exoribonuclease EXOSC10/Rrp6 processes and degrades RNA, regulates gene expression and participates in DNA double‐strand break repair and control of telomere maintenance via degradation of the telomerase RNA component. EXOSC10/Rrp6 is
Igor Stuparević, Ana Novačić, A. Rachid Rahmouni, Anne Fernandez, Ned Lamb, Michael Primig   +5 more
openalex   +3 more sources

Analogs of the Catechol Derivative Dynasore Inhibit HIV-1 Ribonuclease H, SARS-CoV-2 nsp14 Exoribonuclease, and Virus Replication

Viruses, 2023
Viral replication often depends on RNA maturation and degradation processes catalyzed by viral ribonucleases, which are therefore candidate targets for antiviral drugs.
A. Asthana, A. Corona, Woo-Jin Shin, M. Kwak, Christina Gaughan, E. Tramontano, Jae U. Jung, R. Schobert, B. Jha, R. Silverman, B. Biersack   +10 more
semanticscholar   +1 more source

Regulation of miRNA content. Part 2. Degradation of miRNAs

Zdorovʹe Rebenka, 2021
The scientific review presents the process of regulation of microRNA content — microRNA degradation. To write the article, information was searched using databases Scopus, Web of Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, The ...
A.E. Abaturov, V.L. Babуch
doaj   +1 more source

Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor. [PDF]

Commun Biol
Lockbaum GJ, Lynes MM, Shen SA, Liu J, Holt N, Nayak SP, Knockenhauer KE, Yao S, Sickmier EA, Raman A, Wu J, Case A, Shehaj L, Buker SM, Grigoriu S, Ribich S, Blakemore SJ, Sparling BA, Duncan KW, Copeland RA, Silver SJ, Boriack-Sjodin PA.   +21 more
europepmc   +2 more sources

The exoribonuclease XRN2 mediates degradation of the long non‐coding telomeric RNA TERRA

FEBS Letters, 2023
The telomeric repeat‐containing RNA, TERRA, associates with both telomeric DNA and telomeric proteins, often forming RNA:DNA hybrids (R‐loops). TERRA is most abundant in cancer cells utilizing the alternative lengthening of telomeres (ALT) pathway for ...
M. Reiss, J. Keegan, Anne Aldrich, Shawn M. Lyons, R. L. Flynn   +4 more
semanticscholar   +1 more source

Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN

bioRxiv, 2021
High-fidelity replication of the large RNA genome of coronaviruses (CoVs) is mediated by a 3′-to-5′ exoribonuclease (ExoN) in non-structural protein 14 (nsp14), which excises nucleotides including antiviral drugs mis-incorporated by the low-fidelity ...
N. H. Moeller, Ke Shi, Özlem Demir, Surajit Banerjee, Lulu Yin, C. Belica, Cameron Durfee, Rommie E. Amaro, H. Aihara   +8 more
semanticscholar   +1 more source

Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity

Nucleic Acids Research, 2021
The emergence of SARS-CoV-2 infection has posed unprecedented threat to global public health. The virus-encoded non-structural protein 14 (nsp14) is a bi-functional enzyme consisting of an exoribonuclease (ExoN) domain and a methyltransferase (MTase ...
Sheng Lin, Hua Chen, Zimin Chen, Fanli Yang, F. Ye, Yue Zheng, Jing Yang, Xi Lin, Honglu Sun, Lingling Wang, A. Wen, Haohao Dong, Q. Xiao, D. Deng, Yu Cao, G. Lu   +15 more
semanticscholar   +1 more source