Characterization of a bafinivirus exoribonuclease activity
Journal of General Virology, 2018 White bream virus (WBV), a poorly characterized plus-strand RNA virus infecting freshwater fish of the Cyprinidae family, is the prototype species of the genus Bafinivirus in the subfamily Torovirinae (family Coronaviridae, order Nidovirales). In common with other nidoviruses featuring >20 kilobase genomes, bafiniviruses have been predicted to encode ...
Izabela, Durzynska +4 more
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Mutational analysis of exoribonuclease I from Saccharomyces cerevisiae [PDF]
Nucleic Acids Research, 1998 Exoribonuclease I from yeast is a 175 kDa protein that is responsible for the majority of cytoplasmic mRNA degradation. Alignment of the Xrn1p sequence with homologs from yeast as well as from higher eukaryotes suggests that the protein is composed of several domains: two acidic N-terminal domains which likely contain the exonuclease, a basic middle ...
A M, Page +4 more
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Processing of RNA Containing 8-Oxo-7,8-Dihydroguanosine (8-oxoG) by the Exoribonuclease Xrn-1
Frontiers in Molecular Biosciences, 2021 Understanding how oxidatively damaged RNA is handled intracellularly is of relevance due to the link between oxidized RNA and the progression/development of some diseases as well as aging.
Cheyenne N. Phillips +5 more
doaj +1 more source
Regulation of tomato fruit ripening [PDF]
, 2009 Fruit ripening is a sophisticatedly orchestrated developmental process, unique to plants, that results in major physiological and metabolic changes, ultimately leading to fruit decay and seed dispersal.
Bouzayen, Mondher +4 more
core +2 more sources
Uridylation and adenylation of RNAs. [PDF]
, 2015 The posttranscriptional addition of nontemplated nucleotides to the 3' ends of RNA molecules can have a significant impact on their stability and biological function.
Chen, XueMei +3 more
core +2 more sources
iCLIP analysis of RNA substrates of the archaeal exosome
BMC Genomics, 2020 Background The archaeal exosome is an exoribonucleolytic multiprotein complex, which degrades single-stranded RNA in 3′ to 5′ direction phosphorolytically. In a reverse reaction, it can add A-rich tails to the 3′-end of RNA.
Jochen Bathke +9 more
doaj +1 more source
Shared properties and singularities of exoribonuclease-resistant RNAs in viruses
Computational and Structural Biotechnology Journal, 2021 What viral RNA genomes lack in size, they make up for in intricacy. Elaborate RNA structures embedded in viral genomes can hijack essential cellular mechanisms aiding virus propagation.
Quentin Vicens, Jeffrey S. Kieft
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Collaborator of alternative reading frame protein (CARF) regulates early processing of pre-ribosomal RNA by retaining XRN2 (5′-3′ exoribonuclease) in the nucleoplasm [PDF]
, 2015 Collaborator of alternative reading frame protein (CARF) associates directly with ARF, p53, and/or human double minute 2 protein (HDM2), a ubiquitin-protein ligase, without cofactors and regulates cell proliferation by forming a negative feedback loop ...
Bertwistle +13 more
core +2 more sources
A New Subclass of Exoribonuclease-Resistant RNA Found in Multiple Genera of
mBio, 2020 Viruses have developed innovative strategies to exploit the cellular machinery and overcome the antiviral defenses of the host, often using specifically structured RNA elements.
Matthew J. Szucs +4 more
doaj +1 more source
Target RNAs strike back on MicroRNAs [PDF]
, 2018 MicroRNAs are extensively studied regulatory non-coding small RNAs that silence animal genes throughout most biological processes, typically doing so by binding to partially complementary sequences within target RNAs.
de la Mata, Manuel +3 more
core +1 more source