Results 71 to 80 of about 14,025 (272)

RISC-interacting clearing 3’- 5’ exoribonucleases (RICEs) degrade uridylated cleavage fragments to maintain functional RISC in Arabidopsis thaliana

eLife, 2017
RNA-induced silencing complex (RISC) is composed of miRNAs and AGO proteins. AGOs use miRNAs as guides to slice target mRNAs to produce truncated 5' and 3' RNA fragments. The 5' cleaved RNA fragments are marked with uridylation for degradation.
Zhonghui Zhang, Fuqu Hu, Min Woo Sung, Chang Shu, Claudia Castillo-González, Hisashi Koiwa, Guiliang Tang, Martin Dickman, Pingwei Li, Xiuren Zhang   +9 more
doaj   +1 more source

Host 5′-3′ Exoribonuclease XRN1 Acts as a Proviral Factor for Measles Virus Replication by Downregulating the dsRNA-Activated Kinase PKR

Journal of Virology, 2022
Measles virus remains a major global health threat due to its high transmissibility and significant morbidity in children and immunocompromised individuals.
Ethan BenDavid, Christian K. Pfaller, Yue Pan, C. E. Samuel, Dzwokai Ma   +4 more
semanticscholar   +1 more source

Analysis of mRNA Decay Intermediates in Bacillus subtilis 3′ Exoribonuclease and RNA Helicase Mutant Strains

mBio, 2022
The ability to rapidly change bacterial gene expression programs in response to environmental conditions is highly dependent on the efficient turnover of mRNA.
Shivani Chhabra, Zachary F. Mandell, Bo Liu, P. Babitzke, D. Bechhofer   +4 more
semanticscholar   +1 more source

A 212-nt long RNA structure in the Tobacco necrosis virus-D RNA genome is resistant to Xrn degradation [PDF]

, 2019
Plus-strand RNA viruses can accumulate viral RNA degradation products during infections. Some of these decay intermediates are generated by the cytosolic 5′-to-3′ exoribonuclease Xrn1 (mammals and yeast) or Xrn4 (plants) and are formed when the enzyme ...
Chaminda, Gunawardene D., Newburn, Laura R., White, K. Andrew   +2 more
core   +1 more source

Structural and functional studies of the decapping exoribonucleases [PDF]

Acta Crystallographica Section A Foundations and Advances, 2014
Recent studies showed that two homologous yeast proteins, Rai1 and Dxo1, function in a quality control mechanism to clear cells of incompletely 5' end-capped messenger RNAs (mRNAs). Rai1 possesses a novel decapping activity that can remove the entire cap structure dinucleotide from an mRNA.
Liang Tong, Jeong Ho Chang
openaire   +2 more sources

An RNA-seq based comparative approach reveals the transcriptome-wide interplay between 3′-to-5′ exoRNases and RNase Y

Nature Communications, 2020
Bacterial RNA degradation is typically initiated by endoribonucleases and followed by exoribonucleases. Here the authors report the targetome of endoRNase Y in Streptococcus pyogenes, revealing the interplay between RNase Y and 3′-to-5′ exoribonuclease ...
Laura Broglia, Anne-Laure Lécrivain, Thibaud T. Renault, Karin Hahnke, Rina Ahmed-Begrich, Anaïs Le Rhun, Emmanuelle Charpentier   +6 more
doaj   +1 more source

Nuclease Activity of the Junín Virus Nucleoprotein C-Terminal Domain

Viruses, 2023
The mammarenavirus Junín (JUNV) is the causative agent of Argentine hemorrhagic fever, a severe disease of public health concern. The most abundant viral protein is the nucleoprotein (NP), a multifunctional, two-domain protein with the primary role as ...
Alicia Armella Sierra, María Eugenia Loureiro, Sebastián Esperante, Silvia Susana Borkosky, Giovanna L. Gallo, Gonzalo de Prat Gay, Nora Lopez   +6 more
doaj   +1 more source

Cellular 5′-3′ mRNA Exoribonuclease XRN1 Inhibits Interferon Beta Activation and Facilitates Influenza A Virus Replication

mBio, 2021
A novel mechanistic discovery reveals that the host decay factor XRN1 contributes to influenza A virus replication, which exploits XRN1 activity to inhibit RIG-I-mediated innate immune response.
Yen-Chin Liu, B. Mok, Pui Wang, R. Kuo, Honglin Chen, S. Shih   +5 more
semanticscholar   +1 more source

Biochemical Characterization of Exoribonuclease Encoded by SARS Coronavirus [PDF]

BMB Reports, 2007
The nsp14 protein is an exoribonuclease that is encoded by severe acute respiratory syndrome coronavirus (SARS-CoV). We have cloned and expressed the nsp14 protein in Escherichia coli, and characterized the nature and the role(s) of the metal ions in the reaction chemistry.
Xiaojiang S. Chen, Qingzhen Liu, Ping Chen, Tao Hu, Deyin Guo, Miao Jiang   +5 more
openaire   +3 more sources

Uridylation and adenylation of RNAs. [PDF]

, 2015
The posttranscriptional addition of nontemplated nucleotides to the 3' ends of RNA molecules can have a significant impact on their stability and biological function.
Chen, XueMei, Mo, BeiXin, Song, JianBo, Song, Jun   +3 more
core   +2 more sources