Results 81 to 90 of about 14,025 (272)

Structural analysis of 3’UTRs in insect flaviviruses reveals novel determinants of sfRNA biogenesis and provides new insights into flavivirus evolution

Nature Communications, 2022
Subgenomic flaviviral RNAs (sfRNAs) are produced by pathogenic flaviviruses to counteract the host antiviral response. sfRNAs are products of incomplete degradation of viral RNA by the host exoribonuclease XRN1 which stalls on XRN1-resistant structural ...
Andrii Slonchak, Rhys Parry, Brody Pullinger, Julian D. J. Sng, Xiaohui Wang, Teresa F. Buck, Francisco J. Torres, Jessica J. Harrison, Agathe M. G. Colmant, Jody Hobson-Peters, Roy A. Hall, Andrew Tuplin, Alexander A. Khromykh   +12 more
doaj   +1 more source

Dynamic Combinatorial Chemistry Unveils Nsp10 Inhibitors with Antiviral Potential Against SARS-CoV-2. [PDF]

Chemistry
This study investigates antiviral strategies targeting SARS‐CoV‐2 by disrupting the protein‐protein interactions of Nsp10 with Nsp14 and Nsp16, which are essential for viral survival. It employs target‐directed dynamic combinatorial chemistry for the identification and synthesis of inhibitors.
Jumde RP, Jézéquel G, Saramago M, Frank N, Adam S, Cunha MV, Bader CD, Gunesch AP, Köhler NM, Johannsen S, Bousis S, Pietschmann T, Matos RG, Müller R, Arraiano CM, Hirsch AKH.   +15 more
europepmc   +2 more sources

iCLIP analysis of RNA substrates of the archaeal exosome

BMC Genomics, 2020
Background The archaeal exosome is an exoribonucleolytic multiprotein complex, which degrades single-stranded RNA in 3′ to 5′ direction phosphorolytically. In a reverse reaction, it can add A-rich tails to the 3′-end of RNA.
Jochen Bathke, A. Susann Gauernack, Oliver Rupp, Lennart Weber, Christian Preusser, Marcus Lechner, Oliver Rossbach, Alexander Goesmann, Elena Evguenieva-Hackenberg, Gabriele Klug   +9 more
doaj   +1 more source

Target RNAs strike back on MicroRNAs [PDF]

, 2018
MicroRNAs are extensively studied regulatory non-coding small RNAs that silence animal genes throughout most biological processes, typically doing so by binding to partially complementary sequences within target RNAs.
de la Mata, Manuel, Fededa, Juan Pablo, Fuchs Wightman, Federico, Giono, Luciana Eugenia   +3 more
core   +1 more source

Discoveries of Exoribonuclease-Resistant Structures of Insect-Specific Flaviviruses Isolated in Zambia

Viruses, 2020
To monitor the arthropod-borne virus transmission in mosquitoes, we have attempted both to detect and isolate viruses from 3304 wild-caught female mosquitoes in the Livingstone (Southern Province) and Mongu (Western Province) regions in Zambia in 2017. A
Christida E. Wastika, Hayato Harima, Michihito Sasaki, Bernard M. Hang’ombe, Yuki Eshita, Yongjin Qiu, William W. Hall, Michael T. Wolfinger, Hirofumi Sawa, Yasuko Orba   +9 more
doaj   +1 more source

RNA turnover: The helicase story unwinds [PDF]

, 1996
Recent results show that RNA helicases play important roles in RNA decay, both as exoribonuclease accessory factors and in communicating signals to RNA decay ...
Jacobs Anderson, John S, Parker, Roy
core   +1 more source

The pseudoknot structure of a viral RNA reveals a conserved mechanism for programmed exoribonuclease resistance

bioRxiv
Exoribonuclease-resistant RNAs (xrRNAs) are viral RNA structures that block degradation by cellular 5′-3′ exoribonucleases to produce subgenomic viral RNAs during infection.
Jeanine G. Gezelle, S. Korn, Jayden T. McDonald, Zhen Gong, Anna Erickson, Chih-Hung Huang, Feiyue Yang, Matt Cronin, Yen-Wen Kuo, B. Wimberly, Anna-Lena Steckelberg   +10 more
semanticscholar   +1 more source

Tissue-specific Salmonella Typhimurium gene expression during persistence in pigs [PDF]

, 2011
Salmonellosis caused by Salmonella Typhimurium is one of the most important bacterial zoonotic diseases. The bacterium persists in pigs resulting in asymptomatic 'carrier pigs', generating a major source for Salmonella contamination of pork.
Boyen, Filip, Haesebrouck, Freddy, Leyman, Bregje, Pasmans, Frank, Van Parys, Alexander, Verbrugghe, Elin   +5 more
core   +2 more sources

Regulation of cytoplasmic RNA stability: lessons from drosophila [PDF]

, 2018
The process of RNA degradation is a critical level of regulation contributing to the control of gene expression. In the last two decades a number of studies have shown the specific and targeted nature of RNA decay and its importance in maintaining ...
Abdelmohsen, Allmang, Ameres, An, Antic, Astuti, Baccarini, Bakheet, Bakheet, Bakheet, Bassett, Bazzini, Berezikov, Bitetti, Boczonadi, Bonneau, Bortolamiol-Becet, Braun, Brown, Burroughs, Cairrao, Cairrao, Callahan, Carballo, Chang, Chang, Chapman, Chapman, Cheadle, Chen, De Almeida, De Lella Ezcurra, Decker, Di Donato, Ding, Duffy, Eberle, Eckmann, Eggens, Eulalio, Faehnle, Fenger-Gron, Forstemann, Frazao, Garneau, Gatfield, Graham, Graham, Grima, Groen, Gudipati, Haas, Hales, Han, Han, Heo, Hopkins, Hou, Iwasaki, Jonas, Jones, Jones, Jones, Juvvuna, Kaberdin, Kadaba, Kahvejian, Katoh, Kim, Kim, Kinoshita, Kiss, Kowalinski, Larimer, Lebreton, Lee, Li, Lim, Lin, Liu, Londin, Lowell, Lubas, Makino, Malecki, Malet, Mamolen, Marin-Vicente, Maryati, Mata, Mitchell, Modepalli, Molleston, Moon, Morris, Mullen, Murakami, Murray, Nagarajan, Newbury, Ng, Nishioka, Ohkura, Okada, Orban, Pandey, Park, Pashler, Peng, Perez-Ortin, Pfeiffer, Pirouz, Preker, Presnyak, Rehwinkel, Reimao-Pinto, Reimao-Pinto, Reis, Reiter, Rissland, Rose, Russo, Schaeffer, Schaeffer, Schaeffer, Schertel, Schneider, Schneider, Schneider, Schoenberg, Sharif, Sinturel, Smith, Snee, Spasic, Staals, Steinbrunn, Suh, Synowsky, Temme, Temme, Tharun, Thomas, Till, Tomari, Tomecki, Tomecki, Towler, Towler, Towler, Ustianenko, Vallejo, Vindry, Wahle, Waldron, Wan, Wasmuth, Wei, Wells, Wolf, Wyers, Wyman, Yamashita, Zabolotskaya, Zhang   +164 more
core   +1 more source

Germline PARN Variants in Telomere Biology Disorders and Challenges in Variant Curation

Molecular Genetics &Genomic Medicine, Volume 13, Issue 6, June 2025.
Only 44% germline variants in poly(A)‐specific ribonuclease (PARN) reported to cause telomere biology disorders (TBDs) meet pathogenic or likely pathogenic (P/LP) classification criteria. Rare PARN variants are frequent across the gene in unaffected individuals.
Hasset T. Nurelegne, Mone't B. Thompson, Kelvin C. de Andrade, Ashley S. Thompson, Lisa J. McReynolds, Marena R. Niewisch, Sharon A. Savage   +6 more
wiley   +1 more source