Results 81 to 90 of about 18,714 (239)

Composition and conservation of the mRNA-degrading machinery in bacteria [PDF]

, 2011
RNA synthesis and decay counteract each other and therefore inversely regulate gene expression in pro- and eukaryotic cells by controlling the steady-state level of individual transcripts.
Dharam Singh, Sue Lin-Chao, Vladimir R Kaberdin   +2 more
core   +4 more sources

Defining substrate specificities of human RNA capping methyltransferases through quantitative assessment of independent yet cooperative activities

Protein Science, Volume 35, Issue 1, January 2026.
Abstract Human RNA capping is critical for mRNA splicing, protection of RNA from 5′ exonucleases in the cytoplasm, and targeting to the ribosome. Human RNMT, CMTR1, and CMTR2 are RNA methyltransferases involved in the RNA capping process. They play a significant role in the proliferation and differentiation of embryonic stem cells and have been ...
Fatemeh Taherian, Mark F. Mabanglo, Taraneh Hajian, Sarah Tucker, Emilija Kalinic, Sumera Perveen, Ahmed Aman, Masoud Vedadi   +7 more
wiley   +1 more source

A DIStinctively novel exoribonuclease that really likes U

The EMBO Journal, 2013
Regulated degradation plays a major role in determining the levels of both non-coding (miRNA) and coding (mRNA) transcripts. Thus, insights into the factors and pathways that influence this process have broad, interdisciplinary implications. New findings by Malecki et al (2013), Lubas et al (2013), and Chang et al (2013) identify the protein Dis3L2 as ...
Imed E, Gallouzi, Jeffrey, Wilusz
openaire   +3 more sources

Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis

iScience, 2021
Summary: Control of mRNA stability and degradation is essential for appropriate gene expression, and its dysregulation causes various disorders, including cancer, neurodegenerative diseases, diabetes, and obesity.
Shohei Takaoka, Akiko Yanagiya, Haytham Mohamed Aly Mohamed, Rei Higa, Takaya Abe, Ken-ichi Inoue, Akinori Takahashi, Patrick Stoney, Tadashi Yamamoto   +8 more
doaj   +1 more source

Structure Modeling Protocols for Protein Multimer and RNA in CASP16 With Enhanced MSAs, Model Ranking, and Deep Learning

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 1, Page 167-182, January 2026.
ABSTRACT We present the methods and results of our protein complex and RNA structure predictions at CASP16. Our approach integrated multiple state‐of‐the‐art deep learning models with a consensus‐based scoring method. To enhance the depth of multiple sequence alignments (MSAs), we employed a large metagenomic sequence database.
Yuki Kagaya, Tsukasa Nakamura, Jacob Verburgt, Anika Jain, Genki Terashi, Pranav Punuru, Emilia Tugolukova, Joon Hong Park, Anouka Saha, David Huang, Daisuke Kihara   +10 more
wiley   +1 more source

Functional Relevance of CASP16 Nucleic Acid Predictions as Evaluated by Structure Providers

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 1, Page 51-78, January 2026.
ABSTRACT Accurate biomolecular structure prediction enables the prediction of mutational effects, the speculation of function based on predicted structural homology, the analysis of ligand binding modes, experimental model building, and many other applications.
Rachael C. Kretsch, Reinhard Albrecht, Ebbe S. Andersen, Hsuan‐Ai Chen, Wah Chiu, Rhiju Das, Jeanine G. Gezelle, Marcus D. Hartmann, Claudia Höbartner, Yimin Hu, Shekhar Jadhav, Philip E. Johnson, Christopher P. Jones, Deepak Koirala, Emil L. Kristoffersen, Eric Largy, Anna Lewicka, Cameron D. Mackereth, Marco Marcia, Michela Nigro, Manju Ojha, Joseph A. Piccirilli, Phoebe A. Rice, Heewhan Shin, Anna‐Lena Steckelberg, Zhaoming Su, Yoshita Srivastava, Liu Wang, Yuan Wu, Jiahao Xie, Nikolaj H. Zwergius, John Moult, Andriy Kryshtafovych   +32 more
wiley   +1 more source

RNA Degradation Assay Using RNA Exosome Complexes, Affinity-purified from HEK-293 Cells

Bio-Protocol, 2017
The RNA exosome complex plays a central role in RNA processing and regulated turnover. Present both in cytoplasm and nucleus, the exosome functions through associations with ribonucleases and various adapter proteins (reviewed in [Kilchert et al., 2016]).
Michal Domanski, John LaCava
doaj   +1 more source

Elucidation of the Photorhabdus temperata Genome and Generation of a Transposon Mutant Library To Identify Motility Mutants Altered in Pathogenesis [PDF]

, 2015
The entomopathogenic nematode Heterorhabditis bacteriophora forms a specific mutualistic association with its bacterial partner Photorhabdus temperata.
Abebe-Akele, Feseha, Bullock, Hannah, Durakovic, Umjia, Gately, Jon, Hurst, Sheldon G., IV, Jackobeck, Ryan, Janicki, Erik, Michaels, Brandye, Rowedder, Holli, Tisa, Louis S.   +9 more
core   +2 more sources

The Arabidopsis deNADding Enzyme DXO1 Modulates the Plant Immunity Response

Plant, Cell &Environment, Volume 49, Issue 1, Page 32-50, January 2026.
ABSTRACT DXO1, the only DXO homolog in Arabidopsis, due to its plant‐specific features, exhibits strong deNADding enzymatic activity but has no apparent role in 5′ QC. Despite its important contribution to plant RNA metabolism, the direct impact of DXO1 enzymatic activity on cellular processes appears surprisingly limited.
Anna Golisz‐Mocydlarz, Monika Zakrzewska‐Placzek, Michal Krzyszton, Nataliia Diachenko, Justyna Piotrowska, Wiktoria Kalbarczyk, Agnieszka Marasek‐Ciolakowska, Joanna Kufel   +7 more
wiley   +1 more source

ISG20L2, a Novel Vertebrate Nucleolar Exoribonuclease Involved in Ribosome Biogenesis [PDF]

Molecular & Cellular Proteomics, 2008
Proteomics analyses of human nucleoli provided molecular bases for an understanding of the multiple functions fulfilled by these nuclear domains. However, the biological roles of about 100 of the identified proteins are unpredictable. The present study describes the functional characterization of one of these proteins, ISG20L2.
Couté, Yohann, Kindbeiter, Karine, Belin, Stéphane, Dieckmann, Régis, Duret, L., Bezin, Laurent, Sanchez, Jean-Charles, Diaz, Jean-Jacques   +7 more
openaire   +4 more sources